New generation rotavirus vaccines [Yeni nesil rotavirus aşıları]

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dc.contributor.authorBal Z.Ş.
dc.contributor.authorKurugöl Z.
dc.date.accessioned2019-10-27T08:20:40Z
dc.date.available2019-10-27T08:20:40Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractRotavirus gastroenteritis (RVGE) is a vaccine-preventable disease that causes hospitalization and deaths due to severe gastroenteritis in developing countries. The World Health Organization (WHO) reported that 801000 children die annually due to gastroenteritis. Improvement in hygienic conditions is insufficient for preventing rotavirus gastroenteritis due to transmission via droplets and resistance to disinfectants; therefore, vaccination is the most effective method for prevention. At present, there are two licensed rotavirus vaccines, monovalent rotavirus vaccine (RV1, Rotarix, GlaxoSmithKline) and pentavalent rotavirus vaccine (RV5, RotaTeq, Merck). The WHO offered to integrate the rotavirus vaccine to the national vaccination programs of all countries worldwide since 2009. Current licensed vaccines have since demonstrated efficacy against severe gastroenteritis and hospitalization in developed countries. In countries with low income and high disease vaccination rate is low because of difficulties in vaccine supply and high cost of the vaccine and consideration about diminished efficacy of the other oral vaccines. Therefore, several groups are led to develop around the world, new rotavirus vaccines. In this review, we provide a summary of the new licensed vaccines with ongoing clinical trials and the locally licensed vaccines. © 2016 by Pediatric Infectious Diseases Society.en_US
dc.identifier.doi10.5152/ced.2016.2142
dc.identifier.endpage27en_US
dc.identifier.issn2148-2926
dc.identifier.issn2148-2926en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://doi.org/10.5152/ced.2016.2142
dc.identifier.urihttps://hdl.handle.net/11454/25753
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherAVES Ibrahim Karaen_US
dc.relation.ispartofCocuk Enfeksiyon Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNew generation rotavirus vaccinesen_US
dc.subjectRotavirusen_US
dc.subjectRotavirus vaccineen_US
dc.titleNew generation rotavirus vaccines [Yeni nesil rotavirus aşıları]en_US
dc.typeReview Articleen_US

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