Radioiodinated magnetic targeted carriers (I-131-MTC)

Basit Öğe Kaydı
dc.contributor.authorDagdeviren, K.
dc.contributor.authorUenak, P.
dc.contributor.authorBekis, R.
dc.contributor.authorBiber, F. Z.
dc.contributor.authorAkdurak, S.
dc.contributor.authorUlker, O.
dc.contributor.authorErgur, B.
dc.contributor.authorErtay, T.
dc.contributor.authorDurak, H.
dc.date.accessioned2019-10-27T19:32:46Z
dc.date.available2019-10-27T19:32:46Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractMagnetically targeted drug delivery by particulate carriers is an efficient method of delivering drugs to localized disease sites, such as tumors. Thus, high concentrations of carrier molecules such as therapeutic radiopharmaceuticals can be achieved near the target site without any toxic effects to normal surrounding tissue. In this study, magnetic targeting carriers (MTC) were radioiodinated with I-131 using three different methods (1) I-131 was directly bound onto MTC, (2) an iron complex of 8-hydroxyquinoline (8-OHQ) has been absorbed onto magnetic microspheres. The iodogen method was performed for the iodination of the complexes. (3) 8-OHQ was radioiodinated before chelating with Fe. Reaction parameters were investigated in order to optimize the final properties of the labeled MTC. The best labeling yield and the best stability were obtained when 8-OHQ was chelated before the radioiodination. Binding efficiency was found to be 99.58%. The labeling of the MTC with I-131 was undertaken to allow for therapy with I-131-labeled MTC with simultaneous imaging.en_US
dc.identifier.doi10.1007/s10967-007-0923-5
dc.identifier.endpage639en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.startpage635en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-0923-5
dc.identifier.urihttps://hdl.handle.net/11454/39353
dc.identifier.volume273en_US
dc.identifier.wosWOS:000248612300023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleRadioiodinated magnetic targeted carriers (I-131-MTC)en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu