Prospective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemia

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dc.contributor.authorDuyu, Muhterem
dc.contributor.authorDurmaz, Burak
dc.contributor.authorGunduz, Cumhur
dc.contributor.authorVergin, Canan
dc.contributor.authorKarapinar, Deniz Yilmaz
dc.contributor.authorAksoylar, Serap
dc.contributor.authorKavakli, Kaan
dc.contributor.authorCetingul, Nazan
dc.contributor.authorIrken, Gulersu
dc.contributor.authorYaman, Yontem
dc.contributor.authorÖzkınay, Ferda
dc.contributor.authorCogulu, Ozgur
dc.date.accessioned2019-10-27T22:05:55Z
dc.date.available2019-10-27T22:05:55Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractDysregulation of microRNA (miRNA) expression contributes to the pathogenesis of several clinical conditions. The aim of this study is to evaluate the associations between miRNAs and childhood acute lymphoblastic leukemia (ALL) to discover their role in the course of the disease. Forty-three children with ALL and 14 age-matched healthy controls were included in the study. MicroRNA microarray expression profiling was used for peripheral blood and bone marrow samples. Aberrant miRNA expressions associated with the diagnosis and outcome were prospectively evaluated. Confirmation analysis was performed by real time RT-PCR. miR-128, miR-146a, miR-155, miR-181a, and miR-195 were significantly dysregulated in ALL patients at day 0. Following a six-month treatment period, the change in miRNA levels was determined by real time RT-PCR and expression of miR-146a, miR-155, miR-181a, and miR-195 significantly decreased. To conclude, these miRNAs not only may be used as biomarkers in diagnosis of ALL and monitoring the disease but also provide new insights into the potential roles of them in leukemogenesis.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S076]en_US
dc.description.sponsorshipThe authors would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK) for financial support under Grant 109S076.en_US
dc.identifier.doi10.1155/2014/967585
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.issn2314-6133en_US
dc.identifier.issn2314-6141en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2014/967585
dc.identifier.urihttps://hdl.handle.net/11454/48648
dc.identifier.wosWOS:000336304000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofBiomed Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleProspective Evaluation of Whole Genome MicroRNA Expression Profiling in Childhood Acute Lymphoblastic Leukemiaen_US
dc.typeArticleen_US

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