Intensive Lipid Reduction and Proinflammatory Markers in the MODEST Study [Modest çaliflmas&203a;nda yog¨un lipid düflürücü tedavi ve proinflematuvar belirteçler]

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dc.contributor.authorKanat M.
dc.contributor.authorYildiz O.
dc.contributor.authorTunçkale A.
dc.contributor.authorCeyhan B.O.
dc.contributor.authorKaragöz Y.
dc.contributor.authorAltuntafl Y.
dc.contributor.authorOg¨uz A.
dc.date.accessioned2019-10-26T22:51:14Z
dc.date.available2019-10-26T22:51:14Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Statin therapy is well known to reduce inflammatory markers such as tumor necrosis factor-?(TNF- ?), interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP). However, whether this relationship is maintained in the setting of targeting very low levels of LDL (<70 mg dl) in patients with type 2 diabetes has not been clearly established. Materials and Methods: We measured hsCRP, IL-6, and TNF- ? in 43 subject enrolled into the multicenter, open-label, crossover prospective study evaluating the effects of lipid-lowering treatment on steroid synthesis in patients with type 2 diabetes (MODEST study). Subjects with diabetes and coronary artery disease were treated with 80 mg of atorvastatin for 12 weeks. The effect of treatment on pro-inflammatory markers was assessed after 12 weeks. Results: High-dose atorvastatin treatment significantly reduced the plasma levels of IL-6 and hsCRP (p<0.05, p<0.001, respectively), but not of TNF- ? (p=0.051). Conclusion: Atorvastatin treatment targeting very low LDL-cholesterol level reduced the levels of several important inflammatory markers in patients with type 2 diabetes and coronary heart disease.en_US
dc.identifier.endpage34en_US
dc.identifier.issn1301-2193
dc.identifier.issn1301-2193en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://hdl.handle.net/11454/20273
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtorvastatinen_US
dc.subjecthsCRPen_US
dc.subjectInterleukin-6en_US
dc.subjectTNF-?en_US
dc.subjectType 2 diabetesen_US
dc.titleIntensive Lipid Reduction and Proinflammatory Markers in the MODEST Study [Modest çaliflmas&203a;nda yog¨un lipid düflürücü tedavi ve proinflematuvar belirteçler]en_US
dc.typeArticleen_US

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