The effects of GnRH an alogs on serum and follicularfluid leptin levels and pregnancy outcomes in short protocols of assisted reproductive technology [Yardi{dotless}mci{dotless} üreme tekniklerinde ki{dotless}sa protokol uygulamalari{dotless}nda GnRH analoglari{dotless}ni{dotless}n serum ve foliküler leptin seviyeleri ve gebelik sonuçlari{dotless} üzerine etkileri]

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dc.contributor.authorErgenoglu M.A.
dc.contributor.authorYeniel A.O.
dc.contributor.authorAkdogan A.
dc.contributor.authorGÖker E.N.T.
dc.contributor.authorTavmergen E.
dc.date.accessioned2019-10-26T21:48:05Z
dc.date.available2019-10-26T21:48:05Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To determine serum and follicular leptin levels in patients using gonadotropin releasing hormone agonist and antagonist in Assisted Reproductive Technology short protocol cycles and to evaluate pregnancy outcomes. Material and Methods: Patients randomly selected to join assisted reproductive technology cycles during February 2004-July 2004 were enrolled in this study. Group 1 consisted of 21 patients receiving r FSH+ GnRH agonists, whereas Group 2 consisted of 34 patients who received r FSH +GnRH antagonists. During the ovulation induction period 5 serum samples were collected (induction day 1, day 3 or antagonist starting day, human chorionic hormone day, oocyte pickup day, and twelfth day of embryo transfer). Follicular fluid samples were collected to be evaluated for leptin, estradiol, prolactin and luteinizing hormone. Results: There was no difference in age, basal FSH, basal LH, and basal E2 between groups. Serum leptin levels were similar in both groups. Also, when each group's serum leptin levels were evaluated according to the presence of pregnancy, there was no significant difference in both groups. When follicle leptin levels were evaluated according to the existence of pregnancy, in both groups the follicle leptin levels were lower in pregnant participants but this difference was not statistically significant. When obesity is defined as body mass index over 26.5, there is a correlation between obesity and leptin levels in Group 2. Conclusion: Our results have shown that both agonists and antagonists have similar efficacy and effect in poor responder women. Leptin levels in either groups, whether pregnant or non-pregnant were not statistically different. This result shows the need for more studies on leptin in infertility. © 2012 by the Turkish-German Gynecological Education and Research Foundation.en_US
dc.identifier.doi10.5152/jtgga.2012.10
dc.identifier.endpage97en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0399en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.5152/jtgga.2012.10
dc.identifier.urihttps://hdl.handle.net/11454/18640
dc.identifier.volume13en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of the Turkish German Gynecology Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectARTen_US
dc.subjectGnRH agonisten_US
dc.subjectGnRH antagonisten_US
dc.subjectLeptinen_US
dc.subjectProlactinen_US
dc.titleThe effects of GnRH an alogs on serum and follicularfluid leptin levels and pregnancy outcomes in short protocols of assisted reproductive technology [Yardi{dotless}mci{dotless} üreme tekniklerinde ki{dotless}sa protokol uygulamalari{dotless}nda GnRH analoglari{dotless}ni{dotless}n serum ve foliküler leptin seviyeleri ve gebelik sonuçlari{dotless} üzerine etkileri]en_US
dc.typeArticleen_US

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