Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model

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dc.contributor.authorTaskin, Banu
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorGunenc, Damla
dc.contributor.authorErbas, Oytun
dc.date.accessioned2019-10-27T11:20:54Z
dc.date.available2019-10-27T11:20:54Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractThe most severe side effect of prolonged MTX treatment is hepatotoxicity. The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model. Twenty-four male rats were included in the study. Sixteen rats were given a single dose of 20 mg/kg MTX to induce liver injury. Eight rats were given no drugs. 16 MTX-given rats were divided into two equal groups. Group 1 subjects were given lactulose 5 g/kg/day, and group 2 subjects were given saline 1 ml/kg/day for 10 days. The rats were then sacrificed to harvest blood and liver tissue samples in order to determine blood and tissue MDA, serum ALT, plasma TNF-alpha, TGF-ss, and PTX3 levels. Histological specimens were examined via light microscopy. Exposure to MTX caused structural and functional hepatotoxicity, as evidenced by relatively worse histopathological scores and increased biochemical marker levels. Lactulose treatment significantly reduced the liver enzyme ALT, plasma TNF-alpha, TGF-ss, PTX3, and MDA levels and also decreased histological changes in the liver tissue with MTX-induced hepatotoxicity in the rat model. We suggest that lactulose has anti-inflammatory and antifibrotic effects on an MTX-induced liver injury model. These effects can be due to the impact of intestinal microbiome.en_US
dc.identifier.doi10.1155/2017/7942531
dc.identifier.issn1687-6121
dc.identifier.issn1687-630X
dc.identifier.issn1687-6121en_US
dc.identifier.issn1687-630Xen_US
dc.identifier.urihttps://doi.org/10.1155/2017/7942531
dc.identifier.urihttps://hdl.handle.net/11454/32882
dc.identifier.wosWOS:000408471800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofGastroenterology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAntifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Modelen_US
dc.typeArticleen_US

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