One-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging study

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dc.contributor.authorŞenk A.M.
dc.contributor.authorİçhedef Ç.
dc.contributor.authorKılçar A.Y.
dc.contributor.authorUçar E.
dc.contributor.authorArı K.
dc.contributor.authorGöksoy D.
dc.contributor.authorParlak Y.
dc.contributor.authorSayıt Bilgin B.E.
dc.contributor.authorTeksöz S.
dc.date.accessioned2019-10-27T08:02:07Z
dc.date.available2019-10-27T08:02:07Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [18F]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 °C for 30 min in a vial containing AO-GlyGly and [18F]FDG solution. The radiolabeled product ([18F]FDG-GlyGly) was obtained with 98.65 ± 0.35% yield without any purification step which makes this method more attractive for 18F radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [18F]FDG tagged GlyGly in vivo. © 2018, Akadémiai Kiadó, Budapest, Hungary.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Management Uniten_US
dc.description.sponsorshipAcknowledgements This study was financially supported by the Ege University Scientific Research Project numbered 2012 NBE 004 (Bomova, Izmir, Turkey). --en_US
dc.identifier.doi10.1007/s10967-018-5772-x
dc.identifier.endpage463en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-018-5772-x
dc.identifier.urihttps://hdl.handle.net/11454/25130
dc.identifier.volume316en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFDGen_US
dc.subjectGlycylglycineen_US
dc.subjectImagingen_US
dc.subjectPETen_US
dc.subjectRadiopharmaceuticalsen_US
dc.titleOne-step conjugation of glycylglycine with [18F]FDG and a pilot PET imaging studyen_US
dc.typeArticleen_US

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