Ocular surface assessment and morphological alterations in meibomian glands with meibography in obstructive sleep apnea Syndrome

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dc.contributor.authorKaraca I.
dc.contributor.authorYagci A.
dc.contributor.authorPalamar M.
dc.contributor.authorTasbakan M.S.
dc.contributor.authorBasoglu O.K.
dc.date.accessioned2019-10-26T21:12:26Z
dc.date.available2019-10-26T21:12:26Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose: To evaluate ocular surface and Meibomian glands morphology of patients with obstructive sleep apnea syndrome (OSAS). Materials and methods: Based on polysomnography, 36 eyes of 36 patients with severe OSAS (Group 1, apnea-hypopnea index (AHI) ?30/h) and 24 eyes of 24 patients with primary snoring or mild OSAS (Group 2, AHI<15/h) were enrolled. Detailed eye examination along with ocular surface staining (fluorescein, 2%) according to Oxford scale, tear film break-up time (t-BUT), Schirmer 1 test, ocular surface disease index (OSDI) scoring, and evaluation of upper and lower eyelid Meibomian glands using infrared filter of slit-lamp biomicroscope were performed. In addition to grading Meibomian gland drop-out, the presence morphologic alterations such as Meibomian gland duct distortion, thinning and dilatation were also assessed. Results: The mean ages were 50.8 ± 8.3 (range, 35–68) and 47.9 ± 10.5 (range, 27–69) in Group 1 and Group 2, respectively (p = 0.616). Best-corrected visual acuity, Schirmer 1 test, Oxford scale and OSDI scores, and lower meiboscores did not differ significantly between groups. In Group 1, average t-BUT was lower (p = 0.003), upper and total (upper + lower) meiboscores were higher as compared to Group 2 (p < 0.05). The frequency of Meibomian gland duct distortion, thinning and dilatation were also significantly greater in Group 1 (p < 0.05). Conclusion: Morphological changes, in addition to Meibomian glands dropout were significant in severe OSAS patients as demonstrated objectively with meibography. Schirmer 1 and t-BUT tests were in favor of evaporative type dry eye syndrome, which also support Meibomian gland alterations in severe OSAS patients. © 2019 Elsevier Inc.en_US
dc.description.sponsorshipScientific Research Foundation of the Graduate School of Southeast University: 2016-TIP-001en_US
dc.description.sponsorshipThis research was supported by Scientific Research Foundation of Ege University School of Medicine ( 2016-TIP-001 ). --en_US
dc.identifier.doi10.1016/j.jtos.2019.06.003
dc.identifier.issn1542-0124
dc.identifier.issn1542-0124en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jtos.2019.06.003
dc.identifier.urihttps://hdl.handle.net/11454/15702
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofOcular Surfaceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdry eyeen_US
dc.subjectMeibographyen_US
dc.subjectMeibomian glanden_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectOcular surfaceen_US
dc.subjectSleep apneaen_US
dc.titleOcular surface assessment and morphological alterations in meibomian glands with meibography in obstructive sleep apnea Syndromeen_US
dc.typeArticleen_US

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