Bioinspired microstructures through decellularization of plants for tissue engineering applications

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dc.authorscopusid58627120800
dc.authorscopusid57226691776
dc.authorscopusid58627840500
dc.authorscopusid58627477900
dc.authorscopusid22837401200
dc.authorscopusid57209069316
dc.contributor.authorArslan, Yağmur
dc.contributor.authorParadiso, Alessia
dc.contributor.authorÇeliktaş, Naz
dc.contributor.authorErdoğan, Tolga
dc.contributor.authorYeşil-Çeliktaş, Özlem
dc.contributor.authorSwieszkowski, Wojciech
dc.date.accessioned2024-08-25T18:51:27Z
dc.date.available2024-08-25T18:51:27Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIn nature, various patterns such as branches, stripes, spirals, and hexagons exist in biological and natural systems, from nano- to macro-scale. These hierarchical structures spontaneously emerge through the self-organization of an ordered structure from a disordered state. Inspired by nature, functional biomaterials are fabricated and utilized in tissue engineering with the implementation of different strategies. Among them, the decellularization of plant tissues envisions the manipulation of decellularized extracellular matrix (dECM) to recapitulate diverse tissues, including bone, neuro, cardiovascular, and vasculature. Decellularized plants have become favorable scaffolds for tissue engineering. Here, nanofibrous microarchitectures can be retained, while liberated from reactive cellular material, nuclear and cytoplasmic components triggering immune responses. However, employing such structures in tissue engineering applications still requires the improvement of both functionalization and biofabrication strategies, aiming to enhance biocompatibility, cell adhesion, and cellular viability. Recent technological advances have given rise to the availability of both immersion and agitation and gravity-driven processes for decellularization, along with methods for assembling multiscale hierarchical structures. Herein, we discuss decellularization approaches for plant tissues, as well as the recellularization of such acellular matrices. Then, recent advances in plant-based constructs as bioinspired materials for tissue engineering applications are discussed. Ultimately, current challenges and limitations are presented, and future developments for cutting-edge research are speculated.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [120N422]; Polish National Centre for Research and Development (NCBR) [POLTUR4/BIOCANCER/3/2021]; Subvention Funds from Warsaw University of Technologyen_US
dc.description.sponsorshipThis research was funded by the Scientific and Technological Research Council of Turkey (TUBITAK) under grant number 120N422, the Polish National Centre for Research and Development (NCBR) within the project POLTUR4/BIOCANCER/3/2021 and Subvention Funds from Warsaw University of Technology.en_US
dc.identifier.doi10.1016/j.eurpolymj.2023.112415
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85172888904en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2023.112415
dc.identifier.urihttps://hdl.handle.net/11454/102596
dc.identifier.volume198en_US
dc.identifier.wosWOS:001077757400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofEuropean Polymer Journalen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectBioinspired materialsen_US
dc.subjectPlant decellularizationen_US
dc.subjectExtracellular matrixen_US
dc.subjectTissue engineeringen_US
dc.subjectPlant-based scaffoldsen_US
dc.subjectExtracellular-Matrixen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectScaffoldsen_US
dc.subjectBoneen_US
dc.subjectHydrogelsen_US
dc.subjectCellsen_US
dc.subjectSterilizationen_US
dc.subjectBiomaterialsen_US
dc.subjectEnhancementen_US
dc.subjectStrategiesen_US
dc.titleBioinspired microstructures through decellularization of plants for tissue engineering applicationsen_US
dc.typeReview Articleen_US

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