Development of functionalized polymeric nanomaterial by organosiliconic reagent for boronate affinity-based dopamine recognition

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dc.authoridUlucan Karnak, Dr. Fulden/0000-0001-5567-0261
dc.authoridAkgöl, Sinan/0000-0002-8528-1854
dc.contributor.authorUlucan-Karnak, Fulden
dc.contributor.authorKuru, Cansu Ilke
dc.contributor.authorAkgol, Sinan
dc.date.accessioned2024-08-31T07:48:06Z
dc.date.available2024-08-31T07:48:06Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractThe dopamine neurotransmitter is mainly responsible for endocrine functions in our body. The increase in the level of dopamine in the human body leads to many disorders such as schizophrenia, uncontrollable tics, addiction, increased tension, desire to act excessively, and carelessness. Decreased levels of dopamine cause problems such as malnutrition, stress, insomnia, and the use of antidepressants. Recognition of dopamine is crucial for clinical experiments. Therefore, the development of recognition surfaces of dopamine is essential for isolation, purification, and determination processes. This study, it was aimed to produce a polymeric nanomaterial that can recognize dopamine. For this purpose, p(HEMA) polymer was synthesized with surfactant-free emulsion polymerization method and silanized by organosilicon reagent (3-aminopropyl) triethoxylsilane (APTES) and modified with phenylboronic acid (PBA). Characterization of the p(HEMA)-APTES-PBA nanopolymeric system for dopamine recognition was performed with Scanning Electron Microscope(SEM), Energy Dispersive Spectrometry (EDS), Fourier Transform Infrared Spectroscopy (FTIR), Zeta-size/zeta-potential analysis, surface area calculations. Dopamine affinity of the p(HEMA)-APTES-PBA was optimized in terms of pH, time, concentration, buffer concentration, and buffer type parameters. Dopamine adsorption of p(HEMA)-APTESPBA nanopolymers was 4,8 times more than epinephrine in specificity analysis. After the 7 adsorption-desorption cycles, the desorption rate was found to be 74.8 %. The developed nanopolymeric system is a convenient method with high adsorption capacity which allows easy and rapid extraction, isolation, and purification of dopamine.en_US
dc.identifier.doi10.1016/j.ica.2023.121881
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-85182407173en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2023.121881
dc.identifier.urihttps://hdl.handle.net/11454/104666
dc.identifier.volume563en_US
dc.identifier.wosWOS:001154617300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectDopamine Recognitionen_US
dc.subjectNanopolymeren_US
dc.subjectOrganosilicon Reagentsen_US
dc.subjectPolymeric Systemsen_US
dc.titleDevelopment of functionalized polymeric nanomaterial by organosiliconic reagent for boronate affinity-based dopamine recognitionen_US
dc.typeArticleen_US

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