In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica [Sarcopoterium spinosum’un Leishmania tropica’ya karşı in vitro anti-leishmanial etkisi]

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dc.contributor.authorCan H.
dc.contributor.authorKayalar H.
dc.contributor.authorBozkurt B.
dc.contributor.authorCan Ş.
dc.contributor.authorDöşkaya M.
dc.contributor.authorTöz S.
dc.date.accessioned2019-10-27T08:02:46Z
dc.date.available2019-10-27T08:02:46Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractComplex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of this study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum against Leishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubated with L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and the percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was obtained with methanol extract (at a dose of 50 µg/ml). In conclusion, S. spinosum may be a potential source for the development of novel therapeutic agents to treat L. tropica infection. © 2018, Chartered Inst. of Building Services Engineers. All rights reserved.en_US
dc.identifier.doi10.1501/Vetfak_0000002870
dc.identifier.endpage377en_US
dc.identifier.issn1300-0861
dc.identifier.issn1300-0861en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://doi.org/10.1501/Vetfak_0000002870
dc.identifier.urihttps://hdl.handle.net/11454/25243
dc.identifier.volume65en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherChartered Inst. of Building Services Engineersen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-leishmanial activityen_US
dc.subjectIn vitroen_US
dc.subjectLeishmania tropicaen_US
dc.subjectSarcopoterium spinosumen_US
dc.titleIn vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica [Sarcopoterium spinosum’un Leishmania tropica’ya karşı in vitro anti-leishmanial etkisi]en_US
dc.typeArticleen_US

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