Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome secondary to antimicrobial therapy in pediatric bone and infections

Basit Öğe Kaydı
dc.authoridSahbudak Bal, Zumrut/0000-0001-9189-8220
dc.authoridGüner Özenen, Gizem/0000-0002-9725-7501
dc.authoridgunay, huseyin/0000-0003-1122-4459
dc.contributor.authorArslan, Sema Yildirim
dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorOzenen, Gizem Guner
dc.contributor.authorBilen, Nimet Melis
dc.contributor.authorAvcu, Gulhadiye
dc.contributor.authorErci, Ece
dc.contributor.authorKurugol, Zafer
dc.date.accessioned2024-08-31T07:47:28Z
dc.date.available2024-08-31T07:47:28Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Bone and joint infections are common in children, particularly those under 10 years of age. While antimicrobial therapy can often successfully treat these infections, surgical drainage may also be necessary. It is important to note that prolonged courses of treatment have been associated with adverse events and drug reactions. Among these, drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome is particularly severe and potentially life -threatening. We aimed to evaluate the cases of DRESS syndrome that develop during the treatment of bone and joint infections. Methods: A retrospective study was conducted at a tertiary -level university hospital between 2015 and 2022 to determine the incidence and outcomes of definite DRESS Syndrome in children under 18 years of age with bone and joint infections. Results: Of 73 patients with bone and joint infections, 16 (21.9 %) children developed antimicrobial therapy -induced DRESS syndrome. Eight (50 %) of these children were boys; the mean age of the patients was 9.76 +/- 5.5 years. DRESS syndrome occurred in 16 children, including 13 children with osteomyelitis, 1 child with osteomyelitis and septic arthritis, and 2 children with septic arthritis and sacroiliitis. The mean duration of intravenous antibiotic therapy was 40.6 +/- 16.6 days; the mean hospital stay was 48.7 +/- 23.7 days; the mean time for the development of DRESS syndrome after starting antibiotics was 19.6 +/- 7.68 days. New onset fever (68.8 %) and rash (43.8 %) were the most common symptoms of DRESS Syndrome. Cefotaxime and vancomycin were drugs responsible for DRESS syndrome in 8 (50 %) of 16. The causative antibiotics were switched to another class of antibiotic, most commonly preferred was ciprofloxacin (n:5; 31.3 %). For children with persistent symptoms, steroids were used in 5 (31.25) patients. Conclusions: Clinicians should be aware of DRESS syndrome in children who develop fever and rash under long-term antibiotics and should check hematological and biochemical parameters to predict the severity of DRESS syndrome. In patients with persistent symptoms, steroids may be used to control the symptoms.en_US
dc.identifier.doi10.1016/j.waojou.2023.100850
dc.identifier.issn1939-4551
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85185879484en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.waojou.2023.100850
dc.identifier.urihttps://hdl.handle.net/11454/104426
dc.identifier.volume17en_US
dc.identifier.wosWOS:001182030500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofWorld Allergy Organization Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectBone And Joint Infectionen_US
dc.subjectDress Syndromeen_US
dc.subjectChildrenen_US
dc.titleDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome secondary to antimicrobial therapy in pediatric bone and infectionsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu