Modification of Polysulfones by Click Chemistry: Amphiphilic Graft Copolymers and Their Protein Adsorption and Cell Adhesion Properties

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dc.contributor.authorYilmaz, Gorkem
dc.contributor.authorToiserkani, Hojjat
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorSakarya, Serhan
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.contributor.authorTorun, Lokman
dc.date.accessioned2019-10-27T21:27:41Z
dc.date.available2019-10-27T21:27:41Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractWell-defined amphiphilic graft copolymer with hydrophobic polysulfone (PSU) backbone and hydrophilic poly(acrylic acid) (PAA) side chains were synthesized and characterized. For this purpose, commercially available PSU was converted to azido-functionalized polymer (PSU-N-3) by successive chloromethylation and azidation processes. Independently, poly(tert-butyl acrylate) (PtBA) with an alkyne-end-group is obtained by using suitable initiator in atom transfer radical polymerization (ATRP). Then, this polymer was successfully grafted onto PSU-N3 by click chemistry to yield polysulfone-graft-poly(tert-butyl acrylate), (PSU-g-PtBA). Finally, amphiphilic polysulfone-graft-poly(acrylic acid), (PSU-g-PAA), membranes were obtained by hydrolyzing precursor the PSU-g-PtBA membranes in trifluoroacetic acid. The final polymer and intermediates at various stages were characterized by H-1 NMR, FTIR, GPC, and SEM analyses. Protein adsorption and eukaryotic and prokaryotic cell adhesion on PSU-g-PAA were studied and compared to those of PSU-g-PtBA and unmodified PSU. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 110 117, 2011en_US
dc.description.sponsorshipIstanbul Technical UniversityIstanbul Technical University; State Planning Organization of Turkey (DPT) [2005K120920]; Hormozgan University, Iranen_US
dc.description.sponsorshipThis work was supported by Istanbul Technical University and the State Planning Organization of Turkey (DPT, project no 2005K120920) One of the authors (H. T.) wants to thank to Hormozgan University, Iran for financial support by means of visiting scholarship.en_US
dc.identifier.doi10.1002/pola.24424
dc.identifier.endpage117en_US
dc.identifier.issn0887-624X
dc.identifier.issn1099-0518
dc.identifier.issn0887-624Xen_US
dc.identifier.issn1099-0518en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage110en_US
dc.identifier.urihttps://doi.org/10.1002/pola.24424
dc.identifier.urihttps://hdl.handle.net/11454/45110
dc.identifier.volume49en_US
dc.identifier.wosWOS:000286344300012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Polymer Science Part A-Polymer Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamphiphilic polymersen_US
dc.subjectclick chemistryen_US
dc.subjectfunctionalization of polymersen_US
dc.subjectgraft copolymersen_US
dc.subjectpoly(ether sulfones)en_US
dc.titleModification of Polysulfones by Click Chemistry: Amphiphilic Graft Copolymers and Their Protein Adsorption and Cell Adhesion Propertiesen_US
dc.typeArticleen_US

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