Clinical, oral immunological and microbiological shifts during and after pregnancy

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dc.authorscopusid36242033700
dc.authorscopusid57208499273
dc.authorscopusid35609889700
dc.authorscopusid52464155600
dc.authorscopusid14059543900
dc.contributor.authorMeriç, P.
dc.contributor.authorSilbereisen, A.
dc.contributor.authorEmingil, G.
dc.contributor.authorÖztürk, V.-Ö.
dc.contributor.authorBostanci, N.
dc.date.accessioned2024-08-25T18:45:57Z
dc.date.available2024-08-25T18:45:57Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Physiological changes and shifts in the oral microbiota composition during pregnancy may affect the maternal immune system. Uncomplicated pregnancy is associated with a T-helper (Th) 2 predominant cytokine regulation (anti-inflammatory), while oral health deterioration during pregnancy is reflected by severe gingival inflammation, a primarily Th1 cytokine phenotype (pro-inflammatory), and oral microbiome alterations. This prospective observational study aimed to evaluate Th cytokine shifts and changes in the oral microbiota composition in saliva of women before and after birth. Material and methods: Saliva (n = 96) was collected before and 6 months after birth, and medical, oral health, and periodontal status were assessed. In a multiplex immunoassay, 10 cytokines were simultaneously analyzed and cumulative Th1 and Th2 cytokine levels and Th1/Th2 ratio were calculated for all groups. Putative periodontal pathogens (n = 6) were evaluated by quantitative real-time polymerase chain reaction. Results: Th2 cytokine levels were significantly lower (p = 0.014) while pro-inflammatory cytokine levels were significantly higher (p < 0.01) during pregnancy than postpartum. Similar Th1 levels were found between the groups (p = 0.143). Th1 and Th2 cytokines positively correlated with periodontal parameters (p < 0.001) and levels of studied bacteria during pregnancy (p < 0.05). Conclusions: This study identified a significantly increased Th1/Th2 cytokine ratio during pregnancy and a positive association with putative periodontal pathogens. This immunological and microbiological deregulation in the oral milieu during pregnancy is suggestive of a destructive inflammatory periodontal profile. Study registration: Clinical Trials.gov (Record BAP-2015). Clinical relevance: Understanding altered oral immunological and microbiological regulation patterns during pregnancy may help improve the inflammatory periodontal profile in pregnant women. © 2023, The Author(s).en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAKen_US
dc.identifier.doi10.1007/s00784-023-05408-1
dc.identifier.issn1432-6981
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85180885041en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-023-05408-1
dc.identifier.urihttps://hdl.handle.net/11454/101749
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectCytokinesen_US
dc.subjectOral immunityen_US
dc.subjectOral microbiotaen_US
dc.subjectPeriodontal diseaseen_US
dc.subjectPregnancyen_US
dc.subjectSalivaen_US
dc.titleClinical, oral immunological and microbiological shifts during and after pregnancyen_US
dc.typeArticleen_US

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