pH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugs

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dc.contributor.authorYilmaz, Gokhan
dc.contributor.authorGuler, Emine
dc.contributor.authorGeyik, Caner
dc.contributor.authorDemir, Bilal
dc.contributor.authorOzkan, Melek
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorOzcelik, Serdar
dc.contributor.authorTimur, Suna
dc.contributor.authorBecer, C. Remzi
dc.date.accessioned2019-10-27T10:42:20Z
dc.date.available2019-10-27T10:42:20Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractOver the past decade, there has been a great deal of interest in the integration of nanotechnology and carbohydrates. The advances in glyconanotechnology have allowed the creation of different bioactive glyconanostructures for different types of medical applications, especially for drug delivery and release systems. Therefore, the use of more efficient biocompatible nanocarriers with high loading capacity, low overall toxicity and receptor-mediated endocytosis specificity is still in focus for the enhancement of the therapeutic effect. Conjugation of sugar derivatives onto gold nanoparticles presents unique properties that include a wide array of assembling models and size-related electronic, magnetic and optical properties. Here, pH-responsive drug-conjugated glycopolymer-coated gold nanoparticles were prepared by functionalization of gold nanoparticles with thiol-terminated glycopolymers and then subsequent conjugation of doxorubicin (DOX). Among the four different glycopolymers, their drug release, physicochemical characterization (spectroscopy, particle size and surface charge) and in vitro bioapplications with four different cell lines were compared. As a result, pH-sensitive drug delivery via sugar-coated AuNPs was performed thanks to hydrazone linkages between glycopolymers and DOX. Comparative viability tests also demonstrated the efficiency of glycopolymer-DOX conjugates by fluorescence cell imaging. The obtained results reveal that AuNP homoglycopolymer DOX conjugates (P4D) have significant potential, especially in human neuroblastoma cells in comparison to cervical cancer cells and lung cancer cells.en_US
dc.description.sponsorshipEngineering and Physical Sciences Research CouncilEngineering & Physical Sciences Research Council (EPSRC) [EP/P009018/1]en_US
dc.description.sponsorshipThis study is supported by the Engineering and Physical Sciences Research Council (Proposal no: EP/P009018/1).en_US
dc.identifier.doi10.1039/c7me00086c
dc.identifier.endpage158en_US
dc.identifier.issn2058-9689
dc.identifier.issn2058-9689en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage150en_US
dc.identifier.urihttps://doi.org/10.1039/c7me00086c
dc.identifier.urihttps://hdl.handle.net/11454/30688
dc.identifier.volume3en_US
dc.identifier.wosWOS:000424988400014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofMolecular Systems Design & Engineeringen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlepH responsive glycopolymer nanoparticles for targeted delivery of anti-cancer drugsen_US
dc.typeArticleen_US

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