A New ß-lapachone derivative from Distictella elongata (vahl) urb.
| dc.contributor.author | Bedir E. | |
| dc.contributor.author | Pereira A.M.S. | |
| dc.contributor.author | Khan S.I. | |
| dc.contributor.author | Chittiboyina A. | |
| dc.contributor.author | Moraes R.M. | |
| dc.contributor.author | Khan I.A. | |
| dc.date.accessioned | 2019-10-27T08:36:04Z | |
| dc.date.available | 2019-10-27T08:36:04Z | |
| dc.date.issued | 2009 | |
| dc.department | Ege Üniversitesi | en_US |
| dc.description.abstract | The present study describes the structure elucidation of the new ß-lapachone type naphthoquinone isolated from the roots of Distictella elongata. Its structure, according to the molecular formula C16H16O6, was identified as 4,7-dihydroxy-10-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione. The structure was assigned by spectrometric methods [HRESIMS, 1D NMR (1H and 13C), and 2D NMR (g-DQF-COSY, g-HMQC and g-HMBC]. Root chloroform extract of D. elongata showed significant inhibition of the growth of SK-MEL (melanoma) and SK-OV-3 (ovary adenocarcinoma) cells with IC50 values of 40 µg mL-1 and 56 µg mL-1, respectively. However, the naphthoquinone was not responsible for the cytotoxic activity exhibited by the extract. ©2009 Sociedade Brasileira de Química. | en_US |
| dc.identifier.doi | 10.1590/S0103-50532009000200026 | |
| dc.identifier.endpage | 386 | en_US |
| dc.identifier.issn | 0103-5053 | |
| dc.identifier.issn | 0103-5053 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.scopusquality | Q3 | en_US |
| dc.identifier.startpage | 383 | en_US |
| dc.identifier.uri | https://doi.org/10.1590/S0103-50532009000200026 | |
| dc.identifier.uri | https://hdl.handle.net/11454/27339 | |
| dc.identifier.volume | 20 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Sociedade Brasileira de Quimica | en_US |
| dc.relation.ispartof | Journal of the Brazilian Chemical Society | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Bignoniaceae | en_US |
| dc.subject | Cerrado | en_US |
| dc.subject | Distictella elongata | en_US |
| dc.subject | Naphthoquinone | en_US |
| dc.title | A New ß-lapachone derivative from Distictella elongata (vahl) urb. | en_US |
| dc.type | Article | en_US |
