99mTc-exorphin C: A new peptide radiopharmaceutical for tumor imaging
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to label exorphin C with 99mTc and to examine its usefulness as opioid receptor binding radiopharmaceutical in Albino Wistar rats. Exorphin C, which is a peptide with 5 aminoacids, was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Labeling efficiency was higher than 98%. The compound was stable for at least 5 hours at room temperature. Mammary tumor bearing Albino Wistar rats were imaged using gamma-camera. Biodistribution studies were also performed. Results demonstrated that 99mTc-glucoheptonate-exorphin C ( 99mTc-GE) analogs may be useful as a new class of receptor-binding peptides for the diagnosis and therapy of some cancer diseases related with opioid receptor-expressing tissues. © 2005 Akadémiai Kiadó.
Açıklama
Anahtar Kelimeler
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
265
Sayı
3
