Antinociceptive and anti-inflammatory activities and acute toxicity of Achillea nobilis subsp. neilreichii extract in mice and rats

Basit Öğe Kaydı
dc.contributor.authorKarabay-Yavasoglu N.U.
dc.contributor.authorKaramenderes C.
dc.contributor.authorBaykan S.
dc.contributor.authorApaydin S.
dc.date.accessioned2019-10-27T08:37:51Z
dc.date.available2019-10-27T08:37:51Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe ethanol extract of Achillea nobilis L. subsp. neilreichii (Kerner) Formanék (Asteraceae) flower heads was investigated for its antinociceptive and anti-inflammatory activities and for acute toxicity in mice and rats. While the extract exhibited an antinociceptive effect during the late phase of the formalin test (100, 200, and 400 mg/kg, i.p.) and an anti-inflammatory effect in the paw edema test (100 and 200 mg/kg, i.p.), it did not exert any significant antinociceptive effect in the tail-flick test. Furthermore, administration of 400 mg/kg extract increased the latency to hot-plate test at 60 and 90 min. No significant change was detected in sensory motor performance. The acute LC50 value of the extract was 4456 mg/kg (i.p.) in mice. The current results demonstrate that an ethanol extract of A. nobilis L. subsp. neilreichii exerts anti-inflammatory activity. © 2007 Informa Healthcare.en_US
dc.identifier.doi10.1080/13880200601113149
dc.identifier.endpage168en_US
dc.identifier.issn1388-0209
dc.identifier.issn1388-0209en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage162en_US
dc.identifier.urihttps://doi.org/10.1080/13880200601113149
dc.identifier.urihttps://hdl.handle.net/11454/27583
dc.identifier.volume45en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofPharmaceutical Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAchillea nobilisen_US
dc.subjectAcute toxicityen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntinociceptiveen_US
dc.subjectAsteraceaeen_US
dc.subjectSubsp. neilreichiien_US
dc.titleAntinociceptive and anti-inflammatory activities and acute toxicity of Achillea nobilis subsp. neilreichii extract in mice and ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu