Polycaprolactone-hydroxy apatite composites for tissue engineering applications

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dc.contributor.authorCesur, Serap
dc.contributor.authorKucukgoksel, Yelda
dc.contributor.authorTasdemir, Seyma
dc.contributor.authorUrkmez, Aylin Sendemir
dc.date.accessioned2019-10-27T10:03:38Z
dc.date.available2019-10-27T10:03:38Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, scaffolds with polycaprolactone (PCL) and hydroxy apatite (HA) were produced. Their properties are not sufficient to be used alone. Oleic Acid (OA) and glycerol monooleate (GMO) as organic additives were selected for a homogeneous distribution of the ceramic material in the polymer matrix. Biocomposite materials were prepared with solvent casting-salt leaching technique using dichloromethane as the solvent. Salt was used as the porosifier. Materials were kept in simulated body fluid (SBF) to determine the bioactivity in vitro conditions. FTIR and EDX analyses for chemical characterization, tensile and compressive tests for mechanical properties, SEM analyses for surface properties and BET analyses for pore sizes, total surface areas and total pore volumes of scaffolds were performed. FTIR, EDX, and SEM analyses were repeated after SBF treatment. Pore diameters were highly increased with 3 and 20 wt% HA addition. Small amount of GMO addition is more effective on pore size. Mechanical properties of scaffolds were suitable for soft tissue applications, as smooth muscle cells, skin and cancellous bone. The cytotoxicity and cell proliferation on scaffolds were studied with smooth muscle cells (SMC) and L929 fibroblastic cells in vitro. No cytotoxic effect was observed for the scaffolds in both cell types. J. VINYL ADDIT. TECHNOL., 24:248-261, 2018. (c) 2016 Society of Plastics Engineersen_US
dc.description.sponsorshipEge UniversityEge University [BAP 12/MUH/040]en_US
dc.description.sponsorshipThis study was supported by Ege University, Scientific Research Project Fund, project BAP 12/MUH/040.en_US
dc.identifier.doi10.1002/vnl.21569
dc.identifier.endpage261en_US
dc.identifier.issn1083-5601
dc.identifier.issn1548-0585
dc.identifier.issn1083-5601en_US
dc.identifier.issn1548-0585en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage248en_US
dc.identifier.urihttps://doi.org/10.1002/vnl.21569
dc.identifier.urihttps://hdl.handle.net/11454/30138
dc.identifier.volume24en_US
dc.identifier.wosWOS:000443688300008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Vinyl & Additive Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePolycaprolactone-hydroxy apatite composites for tissue engineering applicationsen_US
dc.typeArticleen_US

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