Antifungal Prophylaxis in Solid Organ Transplant Recipients

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dc.contributor.authorSenol, Sebnem
dc.contributor.authorKutsoylu, Oya Eren
dc.contributor.authorKaya, Onur
dc.contributor.authorAvci, Meltem
dc.contributor.authorTasbakan, Meltem Isikgoz
dc.contributor.authorOguz, Vildan Avkan
dc.contributor.authorBaysan, Betil Ozhak
dc.contributor.authorCavus, Sema Alp
dc.contributor.authorCetin, Cigdem Banu
dc.contributor.authorErgin, Cagri
dc.contributor.authorErtugrul, Bulent
dc.contributor.authorKutlu, Selda Sayin
dc.contributor.authorKutlu, Murat
dc.contributor.authorMermut, Gulsen
dc.contributor.authorMetin, Dilek Yesim
dc.contributor.authorOzturk, Barcin
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorTurhan, Ozge
dc.contributor.authorYapar, Nur
dc.date.accessioned2019-10-27T22:12:16Z
dc.date.available2019-10-27T22:12:16Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractSolid organ transplantation (SOT) is a treatment method that improves quality of life and survival of patients with end-stage organ failure. Immunosuppressive treatments given to these patients may predispose to the development of invasive fungal infections (IFI). The incidence of IFI in SOT recipients, which is between 5% and 42%, depends on the organ to be transplanted. Although Candida spp., followed by Aspergillus spp. are the most common microorganisms, among fungal pathogens, this situation varies according to transplant type. The mortality rate associated with these IFI can be high. Therefore, antifungal prophylaxis may be necessary for SOT recipients. Many transplantation centers employ antifungal strategies according to their own experience because of the lack of randomized controlled studies. If the antifungal prophylaxis is given to all patients, antimicrobial resistance and drug-drug interactions may occur. Therefore, it is important to identify patients at a high risk of developing IFI. In this paper, epidemiology, risk factors, literature data and antifungal prophylaxis associated with IFI in liver, kidney, small intestine, pancreas, heart, and lung transplant recipients are reviewed.en_US
dc.identifier.doi10.4274/mjima.2015.7
dc.identifier.issn2147-673X
dc.identifier.urihttps://doi.org/10.4274/mjima.2015.7
dc.identifier.urihttps://hdl.handle.net/11454/49329
dc.identifier.volume4en_US
dc.identifier.wosWOS:000219732100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofMediterranean Journal of Infection Microbes and Antimicrobialsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSolid organ transplantationen_US
dc.subjectantifungal prophylaxisen_US
dc.subjectinvasive fungal infectionen_US
dc.subjectposaconasoleen_US
dc.subjectamphotericin Ben_US
dc.titleAntifungal Prophylaxis in Solid Organ Transplant Recipientsen_US
dc.typeReview Articleen_US

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