Association of angiotensin-converting enzyme I/D and eNOS G894T gene polymorphisms with erectile dysfunction [Converting enzim I/D ve eNOS G894T gen polimorfi{dotless}zmlerinin erektil disfonksiyon ile ilişkisi]

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dc.contributor.authorÇam F.S.
dc.contributor.authorGümüş B.H.
dc.contributor.authorVar A.
dc.contributor.authorBerdeli A.
dc.date.accessioned2019-10-27T08:34:13Z
dc.date.available2019-10-27T08:34:13Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Recent studies suggest that angiotensin II and nitric oxide (NO) may modulate penile smooth muscle tone and contractility. Because genotypes of the angiotensin converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) polymorphisms have been associated with disorders in the vascular system, in this study, we investigated an association between the ACE I/D and eNOS G894T gene polymorphisms and erectile dysfunction (ED). Material and Methods: A total of 44 patients and 45 control subjects were included in the study. Diagnosis of erectile dysfunction (< 26) was provided by International Index of Erectile Function (IIEF). The ACE I/D ve eNOS G894T gene polymorphisms were genotyped using PCR and RFLP. Results: No significant case-control difference was observed for the ACE I/D and eNOS G894T gene polymorphisms either by genotype or allele frequencies [(ACE I/D-X2= 0.930 p= 0.628) and eNOS 894 G/T-X2= 2.114 p = 0.348)]. In addition, there was no significant difference between ACE I/D (X2= 3.174 p= 0.787) and eNOS G894T (X2= 4.320 p= 0.633) and IIEF scores among the patient group. Conclusion: In this study, no association was found between ACE I/D and eNOS G894T gene polymorphisms and erectile dysfunction in the Turkish population studied. © 2011 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2009-16635
dc.identifier.endpage437en_US
dc.identifier.issn1300-0292
dc.identifier.issn1300-0292en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage432en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2009-16635
dc.identifier.urihttps://hdl.handle.net/11454/26997
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAngiotensin-converting enzymeen_US
dc.subjectErectile dysfunctionen_US
dc.subjectPolymorphismen_US
dc.titleAssociation of angiotensin-converting enzyme I/D and eNOS G894T gene polymorphisms with erectile dysfunction [Converting enzim I/D ve eNOS G894T gen polimorfi{dotless}zmlerinin erektil disfonksiyon ile ilişkisi]en_US
dc.typeArticleen_US

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