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Öğe Alterations in quality characteristics and bioactive compounds of blackberry fruits subjected to postharvest salicylic acid treatment during cold storage(Wiley, 2024) Sakaldas, Mustafa; Sen, Fatih; Gundogdu, Muttalip; Aglar, ErdalBlackberry deteriorates rapidly after harvest due to its sensitive structure, limiting their storage time to about a week and resulting in significant economic losses. The study was conducted to determine the effects of salicylic acid applications on postharvest fruit quality in blackberries, the harvested fruit was immersed in salicylic acid solutions prepared at concentrations of 0.5, 1, and 1.5 mM for 15 min. Measurements and analyses such as weight loss, decay rate, soluble solids contents (SSC), pH, acidity, respiration rate, vitamin C, organic acids, and phenolic compounds were performed on fruits stored for 12 days with intervals of 4 days. Applying salicylic acid to fruits resulted in significantly less weight loss and decay rate. Salicylic acid application was effective in increasing SSC rate and decreasing titratable acidity with increasing storage time, and lower SSC and higher titratable acidity were measured with this application. Salicylic acid maintained organic acids and vitamin C postharvest. The decreases in individual phenolic compound levels occurred with extended storage time. Salicylic acid application generally was effective in maintaining concentrations of phenolic compounds during storage, and it was found to be effective on fruit quality, with effectiveness varying depending on application dosage. The study identified 1.5 mM as the most effective dosage of salicylic acid, which could be utilized to maintain postharvest quality and extend cold storage in blackberries. A study was conducted to assess the effects of salicylic acid on postharvest blackberry quality. Measurements such as weight loss, decay rate, soluble solids contents, pH, titratable acidity, respiration rate, vitamin C, organic acids, and phenolic compounds were taken over 12 days at 4-day intervals. Salicylic acid-treated fruits showed significantly less weight loss and decay. It also helped maintain organic acids, vitamin C, and phenolic compounds.imageÖğe Novel constitutive models, challenges and opportunities of shape memory polymer composites(Emerald Group Publishing Ltd, 2024) Uyan, Merve; Celiktas, Melih SonerShape memory polymers (SMPs) are smart materials that have been widely accepted in potential applications ranging from biomedical devices to aerospace. Despite their limitations in engineering applications, SMPs have been utilized for strengthening, innovation and improvement of driving methods, leading to an increase in research on SMP composites (SMPCs). In this review, SMPs used in the production, actuation mechanisms, fabrication and testing methods of SMPCs are presented. Current and potential applications and novel constitutive models that have a very important place in elucidating the interface of SMPCs are introduced. Finally, challenges and opportunities are presented to provide future prospects for SMPCs.Öğe Development of Trp-AuNPs-rGO based electrochemical active biosensing interface for dopamine detection(Elsevier, 2024) Varma, Jyoti; Maan, Karan Singh; Mohiuddin, Sagra; Karnak, Fulden Ulucan; Narang, Jagriti; Shukla, Sudheesh K.; Choudhary, MeenakshiNeurotransmitters are essential for learning, mental alertness, blood flow, and emotions. An imbalance of neurotransmitters in the human system causes neurological disorders. An imbalance of dopamine, a neurotransmitter, can cause severe diseases such as Parkinson's disease, restless legs syndrome, depression, schizophrenia, and attention deficit hyperactivity disorder (ADHD). Dopamine detection is essential but requires high sensitivity, temporal resolution, and favorable electrochemical techniques for the sensing mechanism. The ultrasensitive and selective real-time diagnosis of dopamine depends on the fabrication of a brain-on-a-chip model. Prior to fabrication of this device, it is very essential to develop a novel metal nanomaterial that exhibits biocompatibility and fast detection and is capable of improving the quality of the device. In this respect, we prepared amino acid-reduced gold nanoparticles that were supported by reduced graphene oxide. The prepared composite has been characterized by various techniques for internal and external morphology. The electrochemical behavior was examined on a glassy carbon electrode via various electrochemical techniques by a potentiostat instrument towards the diagnosis of dopamine at a micromolar level in the presence of its interference. Finally, as expected, we found 43.59 mu A mu M-1cm-2 sensitivity toward DA in the linear range of 1-11 mu M. Trp-AuNPS-rGO shows promising results toward the diagnosis of dopamine in the presence of its interference and proves that this nanomaterial will be very promising toward the fabrication of a brain-on chip.Öğe Discovery of a Uracil-Derived Small Organic Ligand with Cytotoxic Effect on Human PC-3 Cell Lines via Apoptosis(Wiley - VCH Verlag Gmbh, 2024) Poslu, Ayse Halic; Balaban, Rumeysa; Nalbantsoy, Ayse; Ertik, Onur; Cecener, Gulsah; Koz, Omer; Koz, GamzeA series of novel 6-amino-5-salicylidene uracils (1-19) were efficiently synthesized from the condensation reaction of 5,6-diamino-1,3-dimethyluracil with substituted salicylaldehydes. The structural characterization of the compounds was performed with spectroscopic methods and elemental analysis. All compounds were evaluated for their in vitro cytotoxic activity against PC-3 (human prostate adenocarcinoma), A549 (human alveolar adenocarcinoma) and SHSY-5Y (human neuroblastoma) cancer cell lines. 3,5-di-tert-Butylsalicylaldehyde derived salicylideneuracil (6ASU-8) showed promising cytotoxic activity against PC-3 cells with an IC50 value of 1.53 +/- 1.01 mu M, compared to doxorubicin, which had an IC50 value of 3.77 +/- 1.34 mu M. 6ASU-8 induced cell cycle arrest at the G2/M phase and promoted apoptosis in PC-3 cells (p<0.05*). Molecular docking results supported the experimental data, indicating that 6ASU-8 is more effective than doxorubicin. Additionally, in silico ADME analysis revealed that 6ASU-8 possesses acceptable predictive physicochemical properties.Öğe Protein-added kefir: biochemical changes in in vitro digestion stages(Wiley, 2024) Saygili, Derya; Karagozlu, CemBackground: While yogurt is the leading fermented milk product, kefir is at the top of the beverage scale. Milk proteins, on the other hand, show specific functions that positively affect healthy nutrition due to the bioactive components, that they provide the necessary amino acids for growth and development. Results: In our study, kefir, a functional product enriched with whey proteins, casein and skimmed milk powder, which are the natural components of milk, was produced. Added-protein kefir samples were applied the in vitro digestion protocol, static method. In order to observe different protein behaviors, samples were taken pre-digestion, at 120th minute and at 240th minute of digestion protocol. ACE and Antioxidant capacity determination analyzes were carried out. While ACE inhibition values were in the range of 78.63-90.30% pre-digestion, they changed in the range of 86.97-96.38% after gastrointestinal digestion. It was determined that the ACE inhibition values of the control sample remained at the lowest level at all stages of digestion and that the difference between all of samples was significant (P < 0.05). Antioxidant activity value ranging from 0.3615-0.5512 meq Ascorbic acid/mu g before digestion was determined as 1.3796-1.9313 meq Ascorbic acid/mu g after gastrointestinal digestion (P < 0.05). Conclusion: Kefir samples containing whey protein stand out with their high potential in terms of both antioxidant activity capacity and ACE inhibition activity at all stages of digestion. Considering their therapeutic effects in fermented products, it is thought that whey proteins among milk proteins will be important alternative sources to enrich the protein content in kefir production. (c) 2024 Society of Chemical Industry.Öğe Vitabiotic: An alternative approach to diabetic foot(Wiley, 2024) Erdem, Huseyin A.; Yalcin, Nazlihan; Kaya, Arda; Tasbakan, MeltemDiabetic foot ulcers and infections are complications that can result in significant morbidity such as the need for amputations, especially in uncontrolled diabetes, thereby profoundly impacting quality of life. While traditional treatments like wound care and antibiotics are effective, there is growing interest in the role of micronutrients (such as vitamins C, D, E, zinc and magnesium) in improving outcomes. This study aims to evaluate how these micronutrients affect diabetic foot infections and the need for amputation, offering insights to enhance overall prognosis. Patients who were hospitalised with a diagnosis of diabetic foot infection in the Infectious Diseases Department of Ege University Faculty of Medicine Hospital between 1 April 2022, and 31 January 2023 were included in the study. The patients' socio-demographic information, characteristics of diabetic wounds, operation history, as well as their levels of micronutrients recorded on the case report form. A total of 202 patients were included in the study. The most common micronutrient deficiencies were vitamin D (69%), vitamin C (64%) and zinc (49%). The amputation rates were significantly higher in patients with deficiencies vitamin C, vitamin A and vitamin D (p < 0.005). Our research revealed a significant prevalence of vitamin deficiencies among the participants, and we observed a noteworthy correlation between amputation rates and these deficiencies. Although these findings show promise, it is essential to emphasise that micronutrient supplements should not replace traditional treatments but should rather be considered as a warning sign for preventing complications, particularly amputation or extremity loss.Öğe The Brussels effect in Ankara: the case of climate policy(Cambridge University Press, 2024) Korkmaz Tumer, Elif; van Zeben, JosephineTurkey's Europeanization process provides a particularly interesting case study of the extra-jurisdictional impact of European Union (EU) law, both through policy convergence and through the so-called Brussels effect. Formally, Turkey must adopt certain EU rules due to its status as an EU candidate country, but its candidacy process has been lengthy and uncertain, resulting in partial and uneven adoption of EU rules. Nevertheless, EU-style policymaking has persisted in various policy areas, including environmental and climate policy. This paper aims to analyze the convergence of climate change policies between the EU and Turkey by employing multidimensional scaling, a method that enables the visualization and examination of the connectivity and intensity of cooperation between states. For the period from 2007 to 2023, our comparative analysis demonstrates that policy divergence occurs when the EU's share of Turkey's total trade decreases and when political challenges are experienced. On the other hand, periods of policy convergence coincide with periods of increased trade volume and expanded trade opportunities. The results suggest that through its market size and regulatory capacity, the EU exerts soft power which forces Turkey to align its climate policies with the EU to protect and maintain its competitiveness in the European marketplace.Öğe Is Conservative Management of Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP) Possible in Children?(Sage Publications Inc, 2024) Celtik, Ulgen; Ertan, Yesim; Ozen, Samim; Goksen, Damla; Celik, AhmetBackground: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly recognized entity with benign clinical characteristics. We aim to compare NIFTP with invasive encapsulated follicular variant papillary carcinoma (fvPTC) and to discuss the management.Methods: Records of patients with fvPTC and NIFTP between 2016 and 2022 were reviewed retrospectively. Two groups were compared according to demographics, surgical management, postoperative management, and long-term follow-up.Results: Twenty patients were included in the study, with 10 in NIFTP group and 10 in fvPTC group. The mean age at operation was 14.10 +/- 2.61 years. Demographics and preoperative nodule sizes (P = .912) were statistically similar between the 2 groups. Although lobectomy was more common in the NIFTP group, this difference was not statistically significant compared to the fvPTC group in terms of surgical treatment. Postoperatively, while no patient received radioactive iodine treatment(RAI) in NIFTP group, 6 patients in fvPTC group did (P = .011). Five patients in NIFTP group and 3 in the fvPTC group were followed up with lobectomy only, without any adverse events or recurrence, for 47.50 +/- 19.25 and 30.10 +/- 19.25 months, respectively.Conclusion: In conclusion, NIFTP appears to be an indolent disease in children. Therefore, observation with lobectomy is sufficient, and RAI is not necessary.Öğe Attitudes and intentions of parents towards the COVID-19 vaccine for their children at a special moment of the pandemic(Peerj Inc, 2024) Odaba, Nurcan Celik; Tayhan, Ali; Mermer, GulengulBackground. This research was conducted following the FDA's approval of the COVID19 vaccine for children aged 5 to 11. Our study aimed to evaluate parents' intentions regarding vaccinating their children in response to the pandemic situation. This period was crucial for understanding parents' initial reactions to health authority recommendations. Methods. This descriptive cross-sectional study was conducted with 940 parents. The data were obtained using the Personal Information Form, the COVID-19 Anxiety Scale, and the Scale of Attitudes Towards COVID-19 Vaccine. Descriptive data analysis involved calculating frequency, percentage, mean, and standard deviation values. We employed Student's t-test, one-way ANOVA tests for analysis. Additionally, various characteristics were analyzed using the two-way logistic regression method. Results. In the study, 85.1% of the parents reported having received the COVID-19 vaccine themselves. However, only 20% stated they would accept the COVID-19 vaccine for their children. The intention to vaccinate their children was influenced by factors such as the parent's age, level of COVID-19 anxiety, vaccination status, and knowledge about the COVID-19 vaccine. Conclusion. Despite the FDA's declaration, it was determined that more than twothirds of parents were hesitant about the COVID-19 vaccine for their children.Öğe Dosimetric Comparison of Plans Obtained by Applying 3DCRT-VMAT and Tomotherapy Radiotherapy Methods in Patients with Thyroid' Ophthalmopathy Diagnosis(Kare Publ, 2024) Dildan, Ozlem; Hoca, Sinan; Olacak, Nezahat; Kamer, SerraOBJECTIVE The aim of our study is to compare the effectiveness of Lateral Three Dimensional Conformal Radiotherapy (3DCRT), Volumetric Modulated Arc Therapy (VMAT) and Helical Tomotherapy (HT) treatment planning systems (TPS) in patients receiving radiotherapy (RT) for thyroid ophthalmopathy (TO). METHODS In our study, each of 10 patients who received TO treatment between 2012 and 2019 were retrospectively planned with three different TPS and dosimetrically obtained data of the doses received by the planned target volume (PTV) and normal tissues for three TPS were compared. RESULTS When the Conformity Index (CI) and Homogenity Index (HI) were evaluated in terms of homogeneous coverage of the PTV target volume, it was shown that HT and VMAT techniques covered the target volume better than 3DCRT. Although the Monitor Unit (MU) value of HT was higher than the other two techniques, it was clearly seen that HT gave better results in the lenses and optic chiasm, which are critical organs. The VMAT technique, on the other hand, gave lower results than HT in the lacrimal glands. It was also observed that HT and VMAT techniques gave better results than 3DCRT in other organs at risk such as eyes, optic nerves and retinas. CONCLUSION The results of the study showed that all treatment techniques can be recommended as safe and effective in the treatment of TO.Öğe Application of ionic liquid-clay nanocomposites on cotton fabric and determination of multi-functional properties(Springer, 2024) Altinisik Tagac, Aylin; Bozaci, EbruGreen chemicals and their applications to textiles became popular for imparting specific functional properties. Because of their complicated applications, the production of multifunctional textiles consumes high energy and produces high amount of wastewater. Therefore, in this study, an innovative one-step approach was used in order to obtain multifunctional cotton fabrics. Montmorillonite/Ionic Liquid (MMT-IL) nanocomposites were formed by using 3 different ionic liquids [IL1 (1-Methyl-3-butylimidazolium chloride, IL2 (1-Methyl-3- octylimidazolium tetrafluoroborate), and IL3 (1-Methyl-3-octylimidazolium bromide)], at 3 different concentrations determined which were based on the cation exchange capacity (CEC) of the montmorillonite clay mineral and MMT-IL nanocomposites. The synthesized MMT-IL nanocomposites were applied to the cotton fabrics by pad-dry-cure method. The pad-dry-cure process was carried out on fabrics also by using 2 different crosslinkers. Modified ethylene urea (MDEU) and (3-Chloropropyl)trimethoxylane (CPTES) were used as crosslinkers. Structural, thermal and surface properties of the MMT-IL nanocomposites and the treated fabrics were determined by FTIR, XRD, TGA, and SEM-EDS analyses. The performance properties of untreated and MMT-IL nanocomposite-modified fabrics were investigated. In order to determine multifunctional properties, antimicrobial, flame retardancy and conductivity values were examined according to the standards. In addition, whiteness index values were also measured to determine whether the MMT-IL nanocomposite modification affected the appearance properties of the fabrics. The performance properties of the fabrics were detailed by using the Box-Behnken experimental design.Graphical abstractThis paper describes the synthesis and application of Ionic Liquid-Clay Nanocomposites to cotton fabrics. The IL-MMT treated fabrics gained antimicrobial, flame retardant, and conductive properties.Öğe Acute pancreatitis occurring after COVID-19 vaccine: a case report and literature review(SpringerNature, 2024) Kabaoglu, Ceren; Ozisik, Hatice; Kocabas, Gokcen Unal; Yurekli, Banu Sarer; Erdogan, MehmetBackgroundVaccines are uncommon causes of pancreatitis, and only a few case reports have described COVID-19 vaccine-related pancreatitis.Case presentationA 45-year-old male patient applied to the emergency department due to having serious abdominal pain. Pfizer-BioNTech COVID-19 vaccine, the last dose was administered 1 week ago. One week after vaccination, he experienced abdominal pain. Laboratory tests demonstrated elevated C-reactive protein, amylase, and lipase levels, and Ig G4 levels were normal. Abdominal computer tomography (CT) displayed acute edematous pancreatitis and peripancreatic inflammatory changes. The patient was diagnosed with acute pancreatitis due to the vaccine.ConclusionWe should be aware that acute pancreatitis induced by the vaccine may occur a few days or weeks after the vaccine, especially in patients who have risk factors for acute pancreatitis.Öğe Implementation of machine learning models as a quantitative evaluation tool for preclinical studies in dental education(Wiley, 2024) Oguzhan, Aybeniz; Peskersoy, Cem; Devrimci, Elif Ercan; Kemaloglu, Hande; Onder, Tolga KaganPurpose and objective: Objective, valid, and reliable evaluations are needed in order to develop haptic skills in dental education. The aim of this study is to investigate the validity and reliability of the machine learning method in evaluating the haptic skills of dentistry students. Materials and methods: One-hundred fifty 6th semester dental students have performed Class II amalgam (C2A) and composite resin restorations (C2CR), in which all stages were evaluated with Direct Observation Practical Skills forms. The final phase was graded by three trainers and supervisors separately. Standard photographs of the restorations in the final stage were taken from different angles in a special setup and transferred to the Python program which utilized the Structural Similarity algorithm to calculate both the quantitative (numerical) and qualitative (visual) differences of each restoration. The validity and reliability analyses of inter-examiner evaluation were tested by Cronbach's Alpha and Kappa statistics (p = 0.05). Results: The intra-examiner reliability between Structural Similarity Index (SSIM) and examiners was found highly reliable in both C2A (alpha = 0.961) and C2CR (alpha = 0.856). The compatibility of final grades given by SSIM (53.07) and examiners (56.85) was statistically insignificant (p > 0.05). A significant difference was found between the examiners and SSIM when grading the occlusal surfaces in C2A and on the palatal surfaces of C2CR (p < 0.05). The concordance of observer assessments was found almost perfect in C2A (kappa = 0.806), and acceptable in C2CR (kappa = 0.769). Conclusion: Although deep machine learning is a promising tool in the evaluation of haptic skills, further improvement and alignments are required for fully objective and reliable validation in all cases of dental training in restorative dentistry.Öğe The multiple nature of CC Com: One of the ultra-short orbital period late-type contact binary systems(Cambridge University Press, 2024) Kocak, DolunayThe study of very short-period contact binaries provides an important laboratory in which the most important and problematic astrophysical processes of stellar evolution take place. Short-period contact systems, such as CC Com, are particularly important for binary evolution. Close binary systems, especially those with multiple system members, have significant period variations, angular momentum loss mechanisms predominance, and pre-merger stellar evolution, making them valuable astrophysical laboratories. In this study, observations of CC Com, previously reported as a binary system, and new observations from the T & Uuml;B & Idot;TAK National Observatory (TUG) and the space-based telescope TESS have revealed that there is a third object with a period of about eight years and a fourth object with a period of about a century orbiting the binary system. From simultaneous analysis of all available light curves and radial velocities, the sensitive orbital and physical parameters of the system components are derived. The orbital parameters of the components are PA=0.2206868 +/- 0.0000002 days,P-B=7.9 +/- 0.1 yr, P-C=98 +/- 5yr,e3=0.06,e4=0.44 and the physical parameters as M-A1=0.712 +/- 0.009 M-circle dot,M-A2=0.372 +/- 0.005 M-circle dot,m(B;i ')=90 degrees=0.074 M-circle dot,m(C;i ')=90 degrees=0.18 M-circle dot,R-A1=0.693 +/- 0.006 R-circle dot,R-A2=0.514 +/- 0.005 R-circle dot,L-A1=0.103 L-circle dot,L-A2=0.081 L-circle dot. Finally, theevolutionary status of the multiple system CC Com and its component stars is discussedÖğe Modification of Waste Pumice Stone for Valorization Purposes(Springer, 2024) Bahtiyari, Muhammed Ibrahim; Aydinlioglu, Omer; Yapar, Saadet; Korlu, AysegulWaste pumice stones used in denim garment finishing processes to provide a unique effect on denim garments causes highly huge environmental load considering the yearly denim production. In this study, it was aimed to reduce the solid waste load by modifying waste pumice stones and finding new areas of use. Contrary to the studies reported in the literature, the modification of waste pumice stone to achieve different structural properties enhancing the moisture adsorption capacity of the material constitutes the novelty of the study. Additionally, the effect of sodium silicate/sodium aluminate ratio on the structural properties was tested. The characterization studies of unmodified and modified waste pumice stones were achieved by the zeta potential and particle size measurements, BET, XRD, FTIR, SEM-EDX analyses and the determination of moisture adsorption/desorption features of the samples. The results of the studies revealed that the amorphous structure of the waste pumice stone was converted into cubic-shaped regular formations by the modification. Further evaluation of XRD measurements demonstrated that the modification led to the transition of amorphous structures to zeolitic structures (Zeolite A and Na-P1 phases). The formation of two different zeolitic structures was attributed to the change in the sodium silicate/sodium aluminate ratio. The results of the moisture adsorption/desorption capacity measurements showed that the modification increased the water vapour adsorption capacity of pumice stone almost 12 times. With these findings, they were identified as possible promising candidates for adsorption.Öğe The efficacy of some endophytic fungi against primary grapevine black foot disease pathogens(Taylor & Francis Ltd, 2024) Yildiz, Murat; Gunhan, Metehan; Savas, Nurdan Gungor; Tosun, NecipBlack foot disease (BFD), primarily attributed to taxa within the genera Dactylonectria and Ilyonectria, is a significant problem that causes serious damage worldwide in many grape and wine regions. This threat could especially be destructive in nurseries and early-stage vineyards, where it induces a decline in growth along with drying, leading to a reduction in the quality and lifespan of the grapevines. This research mainly focused on assessing the biocontrol capabilities of endophytic isolates derived from grapevine saplings, specifically Acremonium sclerotigenum and Clonostachys rosea. The study aimed to assess their effectiveness against the major pathogens responsible for BFD, including Dactylonectria macrodidyma, D. torresensis, and I. liriodendri, under laboratory and in vivo conditions. In the conducted paired culture assays, Trichoderma harzianum KRL-AG2 was employed for comparative purposes. On the 28th day of antagonistic tests, the inhibition response of A. sclerotigenum (>= 94%) and C. rosea (>90%) isolates against the three species of BFD, D. macrodidyma, D. torresensis, and I. liriodendri, reached the maximum inhibition rate. Based on the in vivo analysis conducted with 1103 P rootstocks, T. harzianum, A. sclerotigenum, and C. rosea isolates significantly reduced the disease severity and supplied notable positive effects on plant growth parameters, including root dry weight, root length, and shoot dry weight. These results suggest that these biocontrol agents have potential for the biological management of BFD.Öğe Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study(Wiley Periodicals, 2024) Kocabas, Umut; Ergin, Isil; Yavuz, Veysel; Altin, Cihan; Kaplan, Mehmet; Yilmaz Oztekin, Gulsum Meral; Turk, Ugur OnselAims We aimed to determine the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and to identify clinical factors associated with their use in patients with heart failure (HF) in a real-life setting. Methods Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study is a multicentre, cross-sectional and observational study that included HF patients in the outpatient setting regardless of ejection fraction from 19 cardiology centres between August 2023 and December 2023. Results The study population consisted of 1923 patients with HF, predominantly men (61.2%), with a median age of 66 (range: 19-101) years. Overall, 925 patients (48.1%) were receiving SGLT2is. Among the study population, 22.1% had HF with preserved ejection fraction, 21.5% had HF with mildly reduced ejection fraction, 56.4% had HF with reduced ejection fraction and the use of SGLT2is was 42.0%, 47.9% and 50.6% in each group, respectively (P = 0.012). The use of SGLT2is was 76.6% in patients with HF and diabetes, 19.8% in patients with HF and chronic kidney disease and 26.8% in patients without diabetes and chronic kidney disease (P < 0.001). Higher education level [odds ratio (OR): 1.80; 95% confidence interval (CI): 1.06-3.05; P = 0.027], higher household income (OR: 3.46; 95% CI: 1.27-9.42; P = 0.015), New York Heart Association functional class IV (OR: 2.72; 95% CI: 1.16-6.35; P = 0.021), diabetes (OR: 9.42; 95% CI: 6.72-13.20; P < 0.001), the use of angiotensin receptor-neprilysin inhibitors (ARNis) (OR: 4.09; 95% CI: 2.39-7.01; P < 0.001), the use of mineralocorticoid receptor antagonists (MRAs) (OR: 2.02; 95% CI: 1.49-2.75; P < 0.001), the use of loop diuretics (OR: 1.62; 95% CI: 1.18-2.22; P = 0.003) and the use of thiazide diuretics (OR: 1.72; 95% CI: 1.30-2.29; P < 0.001) were independently associated with the use of SGLT2is. Conversely, atrial fibrillation (OR: 0.63; 95% CI: 0.45-0.88; P = 0.008), chronic kidney disease (OR: 0.53; 95% CI: 0.37-0.76; P = 0.001), the use of dihydropyridine calcium channel blockers (OR: 0.68; 95% CI: 0.48-0.98; P = 0.042) and the use of statins (OR: 0.67; 95% CI: 0.49-0.91; P = 0.010) were independently associated with the non-use of SGLT2is. Conclusions The RED-HEART study provided comprehensive real-world data about implementing SGLT2is in patients with HF. These results suggest that there is a need for organized action and close collaboration between healthcare providers to improve the implementation of SGLT2is, especially in patients with HF with preserved ejection fraction and chronic kidney disease.Öğe A new derivative of 1-allyl-3-methylimidazolium chloride as ionic liquid compound: Synthesis, physical properties and DFT studies(Elsevier, 2024) Yildiz, Murat; Gumustas, Sila; Kinal, Armagan; Alp, SerapThis study aimed to improve the physical properties of 1-allyl-3-methylimidazolium chloride (AMIMCl) by synthesizing a new derivative, 1-allyl-2-hydroxymethyl-3-methylimidazolium chloride (AHMMIMCl). The synthesized AHMMIMCl was characterized using FT-IR, (HNMR)-H-1, (CNMR)-C-13, TGA, and DSC techniques, and its physical and computational properties were compared with those of AMIMCl. Experimentally, AHMMIMCl exhibited a lower viscosity (Delta eta =267.57 cP), a significantly reduced melting point (Delta T =similar to 100 degrees C), and lower conductivity (Delta(sigma max)=30.72 mS.cm(-1) at 25 degrees C). The stable geometries of the cations, ion-pairs, and dimer structures were estimated employing DFT methods. The nature of the cation-anion interaction was analyzed by the natural bond orbital (NBO) and electrostatic potential (ESP) analyses. The physical properties of the newly synthesized compound are found to be in agreement with DFT calculations. Additionally, the new derivative demonstrated enhanced viscosity and melting point compared to the parent compound (AMIMCl), with no significant alteration observed in the hydrogen bond length within the anion-cation interaction. These results indicate the potential applicability of the new product as a substitute for AMIMCl.Öğe The assessment of attentional bias to cleanliness stimuli in different versions of the dot-probe task: Evidence for a motivational account(Sage Publications Ltd, 2024) Boga, Merve; Wentura, DirkVogt et al. (2011) investigated the role of goal-relevance in attention. Specifically, they induced the emotional state of disgust and showed an attentional bias (AB) to goal-related stimuli (i.e., cleanliness pictures) using the dot-probe task. In two experiments, we tested (a) an alternative interpretation and (b) the role of an important methodological feature of the dot-probe task. As the effect can be interpreted alternatively as affective counter-regulation (i.e., cleanliness-related pictures attracted attention because they are positive in the negative disgust state), we added positive stimuli to test whether the AB in the disgust state extends to these stimuli. In Experiment 1, we used the location dot-probe task. That is, participants had to categorise the location of the target. It can be argued that this task confounds attentional processes with response priming processes. In Experiment 2, we used a discrimination dot-probe task, that is, participants had to categorise a target feature that varied orthogonally to location, thus eliminating the confound. In Experiment 1, we did not replicate the effect of emotional state on AB for cleanliness stimuli, whereas in Experiment 2, we did. Mean AB scores for positive stimuli were not affected by emotional state. Two conclusions were drawn: First, the result of Experiment 2 supports the motivational account of Vogt and colleagues. Second, the results support the use of the discrimination task for both theoretical reasons (i.e., effects can be more clearly interpreted as based on attentional processes) and empirical reasons (i.e., the location task did not replicate the expected pattern).Öğe Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS): a family with five affected sibs from Turkey(BMC, 2024) Gokcay, Figen; Baskan, Gulcan Nesem; Sahbaz, Irmak; Koc, Muge Kovancilar; Basak, A. Nazli; Celebisoy, NeseBackgroundCerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS), a relatively common cause of late-onset progressive ataxia, is a genetic disease characterised by biallelic pentanucleotide AAGGG repeat expansion in intron 2 of the replication factor complex subunit 1 gene. Herein, we describe the first molecularly confirmed CANVAS family with five affected siblings from Turkey.Case presentationThe family comprised seven siblings born from healthy non-consanguineous parents. CANVAS phenotype was present in five of them; two were healthy and asymptomatic. Chronic cough was the first symptom reported in all five siblings, followed by the development of sensory symptoms, oscillopsia and imbalance. Clinical head impulse test (HIT) was positive in all cases and video HIT performed on three patients revealed very low vestibulo-ocular reflex gains bilaterally. Magnetic resonance imaging and nerve conduction studies revealed cerebellar atrophy and sensory neuronopathy, respectively. RP-PCR confirmed the homozygous presence of the AAGGG repeat expansion in all five cases.ConclusionGenetic screening for CANVAS should be considered in all patients with late-onset ataxia, sensory disturbances and vestibular involvement, especially in the presence of chronic cough.
