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The multiple nature of CC Com: One of the ultra-short orbital period late-type contact binary systems
(Cambridge University Press, 2024) Kocak, Dolunay
The study of very short-period contact binaries provides an important laboratory in which the most important and problematic astrophysical processes of stellar evolution take place. Short-period contact systems, such as CC Com, are particularly important for binary evolution. Close binary systems, especially those with multiple system members, have significant period variations, angular momentum loss mechanisms predominance, and pre-merger stellar evolution, making them valuable astrophysical laboratories. In this study, observations of CC Com, previously reported as a binary system, and new observations from the T & Uuml;B & Idot;TAK National Observatory (TUG) and the space-based telescope TESS have revealed that there is a third object with a period of about eight years and a fourth object with a period of about a century orbiting the binary system. From simultaneous analysis of all available light curves and radial velocities, the sensitive orbital and physical parameters of the system components are derived. The orbital parameters of the components are PA=0.2206868 +/- 0.0000002 days,P-B=7.9 +/- 0.1 yr, P-C=98 +/- 5yr,e3=0.06,e4=0.44 and the physical parameters as M-A1=0.712 +/- 0.009 M-circle dot,M-A2=0.372 +/- 0.005 M-circle dot,m(B;i ')=90 degrees=0.074 M-circle dot,m(C;i ')=90 degrees=0.18 M-circle dot,R-A1=0.693 +/- 0.006 R-circle dot,R-A2=0.514 +/- 0.005 R-circle dot,L-A1=0.103 L-circle dot,L-A2=0.081 L-circle dot. Finally, theevolutionary status of the multiple system CC Com and its component stars is discussed
Modification of Waste Pumice Stone for Valorization Purposes
(Springer, 2024) Bahtiyari, Muhammed Ibrahim; Aydinlioglu, Omer; Yapar, Saadet; Korlu, Aysegul
Waste pumice stones used in denim garment finishing processes to provide a unique effect on denim garments causes highly huge environmental load considering the yearly denim production. In this study, it was aimed to reduce the solid waste load by modifying waste pumice stones and finding new areas of use. Contrary to the studies reported in the literature, the modification of waste pumice stone to achieve different structural properties enhancing the moisture adsorption capacity of the material constitutes the novelty of the study. Additionally, the effect of sodium silicate/sodium aluminate ratio on the structural properties was tested. The characterization studies of unmodified and modified waste pumice stones were achieved by the zeta potential and particle size measurements, BET, XRD, FTIR, SEM-EDX analyses and the determination of moisture adsorption/desorption features of the samples. The results of the studies revealed that the amorphous structure of the waste pumice stone was converted into cubic-shaped regular formations by the modification. Further evaluation of XRD measurements demonstrated that the modification led to the transition of amorphous structures to zeolitic structures (Zeolite A and Na-P1 phases). The formation of two different zeolitic structures was attributed to the change in the sodium silicate/sodium aluminate ratio. The results of the moisture adsorption/desorption capacity measurements showed that the modification increased the water vapour adsorption capacity of pumice stone almost 12 times. With these findings, they were identified as possible promising candidates for adsorption.
The efficacy of some endophytic fungi against primary grapevine black foot disease pathogens
(Taylor & Francis Ltd, 2024) Yildiz, Murat; Gunhan, Metehan; Savas, Nurdan Gungor; Tosun, Necip
Black foot disease (BFD), primarily attributed to taxa within the genera Dactylonectria and Ilyonectria, is a significant problem that causes serious damage worldwide in many grape and wine regions. This threat could especially be destructive in nurseries and early-stage vineyards, where it induces a decline in growth along with drying, leading to a reduction in the quality and lifespan of the grapevines. This research mainly focused on assessing the biocontrol capabilities of endophytic isolates derived from grapevine saplings, specifically Acremonium sclerotigenum and Clonostachys rosea. The study aimed to assess their effectiveness against the major pathogens responsible for BFD, including Dactylonectria macrodidyma, D. torresensis, and I. liriodendri, under laboratory and in vivo conditions. In the conducted paired culture assays, Trichoderma harzianum KRL-AG2 was employed for comparative purposes. On the 28th day of antagonistic tests, the inhibition response of A. sclerotigenum (>= 94%) and C. rosea (>90%) isolates against the three species of BFD, D. macrodidyma, D. torresensis, and I. liriodendri, reached the maximum inhibition rate. Based on the in vivo analysis conducted with 1103 P rootstocks, T. harzianum, A. sclerotigenum, and C. rosea isolates significantly reduced the disease severity and supplied notable positive effects on plant growth parameters, including root dry weight, root length, and shoot dry weight. These results suggest that these biocontrol agents have potential for the biological management of BFD.
Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study
(Wiley Periodicals, 2024) Kocabas, Umut; Ergin, Isil; Yavuz, Veysel; Altin, Cihan; Kaplan, Mehmet; Yilmaz Oztekin, Gulsum Meral; Turk, Ugur Onsel
Aims We aimed to determine the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) and to identify clinical factors associated with their use in patients with heart failure (HF) in a real-life setting. Methods Real-world data on Empagliflozin and Dapagliflozin use in patients with HEART failure: The RED-HEART study is a multicentre, cross-sectional and observational study that included HF patients in the outpatient setting regardless of ejection fraction from 19 cardiology centres between August 2023 and December 2023. Results The study population consisted of 1923 patients with HF, predominantly men (61.2%), with a median age of 66 (range: 19-101) years. Overall, 925 patients (48.1%) were receiving SGLT2is. Among the study population, 22.1% had HF with preserved ejection fraction, 21.5% had HF with mildly reduced ejection fraction, 56.4% had HF with reduced ejection fraction and the use of SGLT2is was 42.0%, 47.9% and 50.6% in each group, respectively (P = 0.012). The use of SGLT2is was 76.6% in patients with HF and diabetes, 19.8% in patients with HF and chronic kidney disease and 26.8% in patients without diabetes and chronic kidney disease (P < 0.001). Higher education level [odds ratio (OR): 1.80; 95% confidence interval (CI): 1.06-3.05; P = 0.027], higher household income (OR: 3.46; 95% CI: 1.27-9.42; P = 0.015), New York Heart Association functional class IV (OR: 2.72; 95% CI: 1.16-6.35; P = 0.021), diabetes (OR: 9.42; 95% CI: 6.72-13.20; P < 0.001), the use of angiotensin receptor-neprilysin inhibitors (ARNis) (OR: 4.09; 95% CI: 2.39-7.01; P < 0.001), the use of mineralocorticoid receptor antagonists (MRAs) (OR: 2.02; 95% CI: 1.49-2.75; P < 0.001), the use of loop diuretics (OR: 1.62; 95% CI: 1.18-2.22; P = 0.003) and the use of thiazide diuretics (OR: 1.72; 95% CI: 1.30-2.29; P < 0.001) were independently associated with the use of SGLT2is. Conversely, atrial fibrillation (OR: 0.63; 95% CI: 0.45-0.88; P = 0.008), chronic kidney disease (OR: 0.53; 95% CI: 0.37-0.76; P = 0.001), the use of dihydropyridine calcium channel blockers (OR: 0.68; 95% CI: 0.48-0.98; P = 0.042) and the use of statins (OR: 0.67; 95% CI: 0.49-0.91; P = 0.010) were independently associated with the non-use of SGLT2is. Conclusions The RED-HEART study provided comprehensive real-world data about implementing SGLT2is in patients with HF. These results suggest that there is a need for organized action and close collaboration between healthcare providers to improve the implementation of SGLT2is, especially in patients with HF with preserved ejection fraction and chronic kidney disease.
A new derivative of 1-allyl-3-methylimidazolium chloride as ionic liquid compound: Synthesis, physical properties and DFT studies
(Elsevier, 2024) Yildiz, Murat; Gumustas, Sila; Kinal, Armagan; Alp, Serap
This study aimed to improve the physical properties of 1-allyl-3-methylimidazolium chloride (AMIMCl) by synthesizing a new derivative, 1-allyl-2-hydroxymethyl-3-methylimidazolium chloride (AHMMIMCl). The synthesized AHMMIMCl was characterized using FT-IR, (HNMR)-H-1, (CNMR)-C-13, TGA, and DSC techniques, and its physical and computational properties were compared with those of AMIMCl. Experimentally, AHMMIMCl exhibited a lower viscosity (Delta eta =267.57 cP), a significantly reduced melting point (Delta T =similar to 100 degrees C), and lower conductivity (Delta(sigma max)=30.72 mS.cm(-1) at 25 degrees C). The stable geometries of the cations, ion-pairs, and dimer structures were estimated employing DFT methods. The nature of the cation-anion interaction was analyzed by the natural bond orbital (NBO) and electrostatic potential (ESP) analyses. The physical properties of the newly synthesized compound are found to be in agreement with DFT calculations. Additionally, the new derivative demonstrated enhanced viscosity and melting point compared to the parent compound (AMIMCl), with no significant alteration observed in the hydrogen bond length within the anion-cation interaction. These results indicate the potential applicability of the new product as a substitute for AMIMCl.
The assessment of attentional bias to cleanliness stimuli in different versions of the dot-probe task: Evidence for a motivational account
(Sage Publications Ltd, 2024) Boga, Merve; Wentura, Dirk
Vogt et al. (2011) investigated the role of goal-relevance in attention. Specifically, they induced the emotional state of disgust and showed an attentional bias (AB) to goal-related stimuli (i.e., cleanliness pictures) using the dot-probe task. In two experiments, we tested (a) an alternative interpretation and (b) the role of an important methodological feature of the dot-probe task. As the effect can be interpreted alternatively as affective counter-regulation (i.e., cleanliness-related pictures attracted attention because they are positive in the negative disgust state), we added positive stimuli to test whether the AB in the disgust state extends to these stimuli. In Experiment 1, we used the location dot-probe task. That is, participants had to categorise the location of the target. It can be argued that this task confounds attentional processes with response priming processes. In Experiment 2, we used a discrimination dot-probe task, that is, participants had to categorise a target feature that varied orthogonally to location, thus eliminating the confound. In Experiment 1, we did not replicate the effect of emotional state on AB for cleanliness stimuli, whereas in Experiment 2, we did. Mean AB scores for positive stimuli were not affected by emotional state. Two conclusions were drawn: First, the result of Experiment 2 supports the motivational account of Vogt and colleagues. Second, the results support the use of the discrimination task for both theoretical reasons (i.e., effects can be more clearly interpreted as based on attentional processes) and empirical reasons (i.e., the location task did not replicate the expected pattern).
Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS): a family with five affected sibs from Turkey
(BMC, 2024) Gokcay, Figen; Baskan, Gulcan Nesem; Sahbaz, Irmak; Koc, Muge Kovancilar; Basak, A. Nazli; Celebisoy, Nese
BackgroundCerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS), a relatively common cause of late-onset progressive ataxia, is a genetic disease characterised by biallelic pentanucleotide AAGGG repeat expansion in intron 2 of the replication factor complex subunit 1 gene. Herein, we describe the first molecularly confirmed CANVAS family with five affected siblings from Turkey.Case presentationThe family comprised seven siblings born from healthy non-consanguineous parents. CANVAS phenotype was present in five of them; two were healthy and asymptomatic. Chronic cough was the first symptom reported in all five siblings, followed by the development of sensory symptoms, oscillopsia and imbalance. Clinical head impulse test (HIT) was positive in all cases and video HIT performed on three patients revealed very low vestibulo-ocular reflex gains bilaterally. Magnetic resonance imaging and nerve conduction studies revealed cerebellar atrophy and sensory neuronopathy, respectively. RP-PCR confirmed the homozygous presence of the AAGGG repeat expansion in all five cases.ConclusionGenetic screening for CANVAS should be considered in all patients with late-onset ataxia, sensory disturbances and vestibular involvement, especially in the presence of chronic cough.
Development of fruit-based drinks fortified with probiotics, Spirulina platensis and pea protein
(Springer, 2024) Yahsi, Yunus; Sengun, Ilkin
The aim of this study was to develop fruit-based drinks enriched with plant-based proteins [Spirulina platensis biomass (0.25%, w/v) and pea protein isolate (5.83%, w/v)] and probiotics (Lacticaseibacillus casei, Lacticaseibacillus rhamnosus, and Lactiplantibacillus plantarum or their combination) (1%, v/v). The drinks were fermented with probiotics at 37 degrees C for 24 h before being stored at 4 degree celsius for 90 days. They were then evaluated for microbiological, physicochemical and sensory properties after fermentation and during storage. The probiotic viability in the fermented drinks was between 8.67 and 9.61 log CFU/mL after fermentation. During storage period, the viable probiotic cell counts in the drinks were greater than 7.36 +/- 0.09 log CFU/mL, while the pH, titratable acidity, total sugar, protein and total phenolic contents of the probiotic drinks were in the range of 3.44-3.96, 0.69-1.37 g lactic acid/100 mL, 9.14-9.62 g/100 mL, 4.39%-4.70%, and 1053.00-1415 mg GAE/L, respectively. Sensory evaluation demonstrated that the drinks enriched with probiotics were equally or more favourably liked than the control sample during the storage. In general, the sample fermented with L. casei (MC) exhibited the highest probiotic, total phenolic content and antioxidant activity at the end of storage. Conversely, the sample fermented with L. rhamnosus (MR) had a high protein content at the end of storage. Consequently, the enrichment of fruit juices with probiotics and plant proteins offers a new alternative to the functional food market.
Acute Suppurative Perichondritis After Helix Piercing in a Child
(Lippincott Williams & Wilkins, 2024) Ozer, Emine Cigdem; Avcu, Gulhadiye; Arslan, Asli; Ekemen, Coskun; Sahbudak Bal, Zumrut
Transcartilaginous ear piercing has be come increasingly popular among teen agers in the last decade. Because of the unique avascular nature of ear cartilage, it re ceives its nutrition from the perichondrium.
First-Drug Efficacy and Drug-Resistant Epilepsy Rates in Children With New-Onset Epilepsies: A Multicenter Large Cohort Study
(Sage Publications Ltd, 2024) Gencpinar, Pinar; Arican, Pinar; Dundar, Nihal Olgac; Kilic, Betul; Sarigecili, Esra; Okuyaz, Cetin; Tekgul, Hasan
Objective: This study aimed to assess the first-drug efficacy rate in newly diagnosed children with epilepsies treated with antiseizure medications. Methods: This retrospective study was conducted on 1003 children (age range: 3-10 years, and the mean duration of follow-up: 22 +/- 13 months) with newly diagnosed epilepsy. The following parameters were evaluated: first-drug efficacy rate, first-drug-failure rate, and drug resistance rate in the cohort. Results: The first-drug-failure rate was defined in 335/1003 (33%) of the patients, no seizure control in 315 (31%), and drug withdrawal in 20 (2%). There was no significant difference between the group with focal-onset seizures and the group with generalized onset seizures. The first-drug efficacy rate was 67% in children with focal-onset seizures and 66% in children with generalized-onset seizures. Adjunctive antiseizure medication therapy was initiated in 335 patients-dual therapy with 180 patients (18%) and polytherapy with 155 (15%). Drug-resistant epilepsy was defined as 15% in the follow-up period. Etiology-specific diagnoses of the cohort were structural (n = 165, 17%), genetic (n = 25, 3%), metabolic (n = 15%), immune-infectious (n = 17 (2%), and unknown (n = 781, 77%). With a comparison of the 2 most common etiology subgroups (structural versus unknown), a first-drug efficacy rate of 53% and a higher prevalence of drug-resistant epilepsy at 30% were observed in children with structural etiology. First-drug efficacy was statistically lower in children without well-defined epilepsy syndromes (65%) compared with the rate of those with well-defined epilepsy syndrome (79%). Conclusion: This study revealed a first-drug failure rate (33%) in the presented cohort with a drug-resistance epilepsy rate (15%).
Phenotypic variations in knee osteoarthritis: insights from MRI and radiographic comparisons
(Springer, 2024) Tosun, Ozgur; Sinci, Kazim Ayberk; Baysan, Caner; Kucukciloglu, Yasemin; Aksit, Mehmet; Kazimoglu, Cemal; Cilengir, Atilla Hikmet
Objective To investigate the correlation between MRI-based phenotypes (cartilage-meniscus, subchondral bone, and inflammatory) and radiography-based atrophic and hypertrophic phenotypes, aiming to demonstrate MRI's diagnostic capability in identifying complex osteoarthritis phenotypes that radiography cannot fully capture. Materials and Methods This single-center retrospective study examined knee radiographs and MRIs of patients from November 2021 to April 2023 to identify osteoarthritis phenotypes. Radiographs were staged by the Kellgren-Lawrence system, and both modalities were classified into atrophic or hypertrophic phenotypes. MRIs were further classified into three phenotypes: cartilage-meniscus, subchondral bone, and inflammatory. Associations between phenotypes, Kellgren-Lawrence stage, age, and gender were analyzed with Pearson chi-square test and student T-test. Reliability measurements were evaluated using kappa statistic. Results A total of 214 knees from 187 individuals (73.3% women, 26.7% men; mean age 57.1 +/- 9.1 years) were included. The hypertrophic MRI phenotype was significantly associated with cartilage-meniscus and subchondral bone phenotypes (p < 0.001). Cartilage-meniscus and subchondral bone phenotypes were less prevalent in Kellgren-Lawrence stage 2 than in stages 3 and 4 (p < 0.001 and p = 0.004, respectively). The subchondral bone phenotype was more common in men (p = 0.022), and the cartilage-meniscus phenotype in the elderly (p < 0.001). Radiography and MRI had substantial agreement (Kappa = 0.637, p < 0.001) in diagnosing hypertrophic and atrophic phenotypes. Conclusion The hypertrophic phenotype was associated with cartilage-meniscus and subchondral bone phenotypes, with lower prevalences in Kellgren-Lawrence stage 2 knees. MRI offers enhanced phenotypic characterization, which facilitates more precise and individualized management in osteoarthritis care. Despite limitations compared to MRI, radiography remains valuable for the evaluation of hypertrophic and atrophic phenotypes.
Diagnostic yield of exome sequencing-based copy number variation analysis in Mendelian disorders: a clinical application
(BMC, 2024) Atik, Tahir; Avci Durmusalioglu, Enise; Isik, Esra; Kose, Melis; Kanmaz, Seda; Aykut, Ayca; Cogulu, Ozgur; Durmaz, Asude; Ozkinay, Ferda
Next-generation sequencing (NGS) coupled with bioinformatic tools has revolutionized the detection of copy number variations (CNVs), which are implicated in the emergence of Mendelian disorders. In this study, we evaluated the diagnostic yield of exome sequencing-based CNV analysis in 449 patients with suspected Mendelian disorders. We aimed to assess the diagnostic yield of this recently utilized method and expand the clinical spectrum of intragenic CNVs. The cohort underwent whole exome sequencing (WES) and clinical exome sequencing (CES). Using GATK-gCNV, we identified 12 pathogenic CNVs that correlated with their clinical findings and resulting in a diagnostic yield of 2.67%. Importantly, the study emphasizes the role of CNVs in the etiology of Mendelian disorders and highlights the value of exome sequencing-based CNV analysis in routine diagnostic processes.
Effects of finishing processes on physical properties of knitted fabrics produced by recycled cotton fibers
(Elsevier Science Ltd, 2024) Utebay, Burcin; Celik, Pinar; Cay, Ahmet
This study examines conventional wet-finishing processes applicable to fabrics containing recycled cotton fibers. The knitted fabrics were produced using open-end and compact yarns, with up to 80% of the cotton fibers being obtained from mechanical recycling of pre-consumer textile wastes. The study evaluated the effects of these finishing processes on the physical properties of the fabrics based on the recycled fiber ratio, yarn type, and yarn count. After determining the parameters for enzymatic bio-polishing, scouring, and color removal processes, two sequential finishing routes were designed: using the fabrics as melange without a dyeing process (F1) or coloring them with color stripping and subsequent dyeing (F2). The resulting fabrics were tested for bursting strength, pilling resistance, weight, thickness, air permeability, and abrasion resistance, and the results were evaluated statistically. The study demonstrated that compact yarns provide superior strength, particularly when the F2 process was employed. The F2 process resulted in high pilling resistance and increased breathability of recycled knitted fabrics. The study concluded that the quality of fabrics containing recycled cotton fibers could be optimized by the selection of the appropriate finishing processes.
Current progress of perovskite solar cells stability with bibliometric study
(Elsevier Science London, 2024) Harito, Christian; Abrori, Syauqi Abdurrahman; Khalil, Munawar; Yuliarto, Brian; Erten Ela, Sule
Perovskite solar cells have matched or even surpassed commercial silicone-based photovoltaics (PVs) in terms of cost effectiveness and power conversion efficiency. However, the stability is quite far behind the commercial silicone-based PV. Humidity, electrical bias, high temperature, and ultraviolet light are the determining stressors in the degradation of perovskite solar cells. This review provides the current advancement (2022 to July 31st, st , 2024) to the stability problem in perovskite solar cells. Equipped with bibliometric study, we deploy keyword analysis, citation analysis, and notable progress to give an overview and latest progress in perovskite solar cells stability. The importance of interface passivation is highlighted. The scalability studies of nontoxic, lead-free, stable perovskite solar cells are expected in near future.
Nursing Students' Operating Room Experiences: A Qualitative Metasynthesis
(Elsevier Science Inc, 2024) Taylan, Secil; Ozkan, Ilknur; Yavuz van Giersbergen, Meryem
Purpose: This study was conducted to analyze the findings of qualitative studies about nursing students' experiences with operating room (OR) practices. There is a need to conduct metasynthesis studies to highlight the overarching dimensions of nursing students' experiences in the OR learning environment, identify and summarize key elements, draw attention to the professional implications of the experience, and then help define the future research agenda. This original study is the first metasynthesis of qualitative studies focusing on nursing students' OR practice experiences. Design: A qualitative metasynthesis. Methods: This metasynthesis study was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement and registered with PROSPERO (International prospective register of systematic reviews) (CRD42021252129). This metasynthesis consists of qualitative studies that included themes, were conducted with nursing students with OR experience, and were published in English between December 2000 and June 2022. Data were analyzed using the two-step metasynthesis procedures proposed by Sandelowski and Barroso. Findings: This metasynthesis study was carried out by analyzing 12 qualitative studies that met the inclusion criteria, reflected the results of a total of 244 nursing students, and were conducted in 7 different countries. As a result of the analysis of the studies, two main themes and seven subthemes were determined about the OR experiences of nursing students. The main themes of the study included (1) the OR environment and (2) professionalism and career choices. Conclusions: The synthesis of studies in this research revealed nursing students' OR experiences and provided evidence about the association between these experiences and their professionalism and career goals. The research drew attention to the limitations and facilitators of the OR learning environment for nursing students and provided guidance for a positive interactive learning environment. (c) 2024 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Spatio-temporal assessment of landscape ecological risk using spatial statistical analysis in a basin of Turkiye
(Springer, 2024) Senay, Diba; Nurlu, Engin
Monitoring the land use/land cover (LU/LC) changes that have occurred with rapid population growth and urbanization since the Industrial Revolution is important for the optimal configuration of landscape patterns and ensuring the sustainability of ecological functions. Spatiotemporal dynamic pattern of LU/LC change using high-resolution land use data is an indicator to evaluate the landscape ecological risk through landscape pattern index analysis. In this study, the landscape ecological risk index (LERi) based on LU/LC change was calculated using remote sensing images of Landsat TM (Thematic Mapper) and OLI (Operational Land Imager) Rdata of a Gediz Mainstream Sub-basin in Turkiye between 1992 and 2022, and the spatial distribution regularity of LERi values was determined with spatial statistical analysis. According to the results, it was determined that the LERi values of the study area changed by 45% in 30 years. The highest change is in the very high-risk class, with an increase of 10.96%, and the least change occurred in the very low-risk class, with a decrease of 1.29%. According to the obtained statistical analysis results, it was determined that the global spatial autocorrelation values analyzed at different grain levels showed positive autocorrelation for both years and that the LERi values tended to have strong spatial clustering. As a result, it is emphasized that strict control measures should be taken for areas showing High-High (HH) autocorrelation type located in the southeast and north-southwest line of the study area at the local level, and ecological restoration applications should be given priority in these areas.
The effects of aromatherapy and music on pain, anxiety, and stress levels in palliative care patients
(Springer, 2024) Akbas Uysal, Duygu; Senuzun Aykar, Fisun; Uyar, Meltem
AimPain and anxiety levels in palliative care patients negatively impact their quality of life, highlighting the need for research on non-pharmacological methods. This study aimed to evaluate the effects of music and aromatherapy interventions on pain, anxiety, and stress levels in these patients. Material and MethodsThe research was designed as a single-blind, four-group, randomized controlled trial. The sample consisted of 88 patients hospitalized in a palliative care center (receiving palliative care services with terminal or advanced diseases). Patients were randomly assigned to four groups (n = 22, music, aromatherapy, music and aromatherapy, and control group). Patients in the experimental groups received the intervention to which they were assigned for 20 min each day for three consecutive days: music, aromatherapy, or music accompanied by aromatherapy. No intervention was applied to the control group. The patients' levels of pain, anxiety, and stress were assessed before and after the intervention using the Visual Analog Scale (VAS), the Facial Anxiety Scale (FAS), and the Distress Thermometer. ResultsNo significant differences were found in the demographic characteristics of the groups (p > 0.05). The Wilcoxon Signed-Rank and Kruskal-Wallis tests indicated statistically significant differences in pre- and post-intervention scores for VAS, FAS, and Distress across all experimental groups on all follow-up days (p < 0.05). ConclusionImplementing music, aromatherapy, and their combination effectively reduced pain, anxiety, and stress levels in palliative care patients, suggesting these non-pharmacological interventions can improve their quality of life. Trial registrationClinicalTrails.gov (Registration number: NCT06024954) at 05-SEP-2024.
Temporal-Spatial Influences on Atlantic Bluefin Tuna CPUE in Recreational Fishery in the Aegean Sea: A Generalized Additive Model Approach
(Central Fisheries Research Inst, 2024) Lopez Mengual, Irene; Ceyhan, Tevfik; Ulas, Ali
The Thunnus thynnus, a sought-after fish in recreational fishing, demands sustainable management due to its migratory nature. However, the lack of data on the impact of recreational fishing hampers understanding. This study aims to address this gap using Catch Per Unit Effort (CPUE) data from fishing contests on the Urla Peninsula (2016-2022). Findings revealed a yearly influence on CPUE, with the mean at 5.56 +/- 0.49 Kgday(-1). The peak was in 2018 with 13.98 Kgday(-1). Individual catches ranged from 305 to 10.45 Kg. 'Catch' was 21 times more prevalent than 'Catch and Release.' More catches occurred in the southern area, possibly due to tuna fattening cages. The study showed a yearly influence, but the dataset is insufficient to fully understand the environmental variables' impact. Despite the limitations, the potential of this data as a future benchmark for recreational fishing efforts is significant.
A comprehensive review on organ-on-chips as powerful preclinical models to study tissue barriers
(IOP Publishing Ltd, 2024) Filiz, Yagmur; Esposito, Alessio; De Maria, Carmelo; Vozzi, Giovanni; Yesil Celiktas, Ozlem
In the preclinical stage of drug development, 2D and 3D cell cultures under static conditions followed by animal models are utilized. However, these models are insufficient to recapitulate the complexity of human physiology. With the developing organ-on-chip (OoC) technology in recent years, human physiology and pathophysiology can be modeled better than traditional models. In this review, the need for OoC platforms is discussed and evaluated from both biological and engineering perspectives. The cellular and extracellular matrix components are discussed from a biological perspective, whereas the technical aspects such as the intricate working principles of these systems, the pivotal role played by flow dynamics and sensor integration within OoCs are elucidated from an engineering perspective. Combining these two perspectives, bioengineering applications are critically discussed with a focus on tissue barriers such as blood-brain barrier, ocular barrier, nasal barrier, pulmonary barrier and gastrointestinal barrier, featuring recent examples from the literature. Furthermore, this review offers insights into the practical utility of OoC platforms for modeling tissue barriers, showcasing their potential and drawbacks while providing future projections for innovative technologies.
Concentrations of radionuclides and trace elements in wetlands
(Springer, 2024) Akakce, Nurdan; Erdemir, Umran Seven; Gorgun, Aysun Ugur; Sert, Ilker; Sac, Murat
Environmental risks in wetlands are considered with radionuclides and trace elements to understand pollution accumulation. In this study, we aimed to determine the levels of radiation and heavy metals in water systems and assess pollution configurations. Radionuclides (222Rn, 210Pb and 210Po) and trace elements (Ag, As, Ba, Be, Cd, Co, Cr, Cu, Fe, Li, Mo, Ni, Pb, V and Zn) were measured to evaluate anthropogenic factors. Water pollution in wetlands was indicated by mean concentrations of 66.2 mBq/L for 222Rn, 3 mBq/L for 210Pb, 42 mBq/L for 210Po, 41 ppb for Zn, 37 ppb for Ba, 190 ppb for Fe and 481 ppb for Sr. These pollutants may be related to industrial facilities in K & imath;rklareli city, T & uuml;rkiye.

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