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Yazar "Zoghi M." seçeneğine göre listele

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  • Küçük Resim Yok
    Öğe
    Angiotensin receptor blockers and risk of cancer [Anjiyotensin reseptör blokerleri ve kanser riski]
    (2011) Zoghi M.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Apical hypertrophic cardiomyopathy coexistent with a myocardial bridging
    (2004) Saygi S.; Türk Ö.U.; Özdogan Ö.; Zoghi M.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Apical hypertrophic cardiomyopathy might lead to misdiagnosis of ischaemic heart disease
    (2008) Duygu H.; Zoghi M.; Nalbantgil S.; Ozerkan F.; Akilli A.; Akin M.; Onder R.; Erturk U.
    Purpose: In this study, demographic, clinic, electrocardiographic and angiographic properties of patients, on whom coronary angiography was performed with the pre-diagnosis of coronary artery disease (CAD) and whose ventriculography demonstrated typical apical hypertrophic cardiomyopathy (AHCM), were investigated. Methods: Seventeen patients (mean age 58 ± 10 years, 10 male) with CAD pre-diagnosis, on whom coronary angiography was performed and had typical spade-like appearance on left ventriculography, were included in the study between January 2000 and May 2005. Results: As risk factor for CAD, 8 (47%) patients had hypertension, 8 (47%) patients had dyslipidaemia, 2 (11%) patients had type 2 diabetes mellitus, 13 (77%) patients had a history of smoking, and 2 (11%) patients had family history. Seven (42%) patients presented unstable angina pectoris, 8 (47%) patients presented stable angina pectoris and 2 (11%) patients were asymptomatic. On coronary angiography, it was determined that 10 (58%) patients had normal coronary arteries, 3 (17%) patients had non-significant stenosis and 4 (25%) patients had myocardial bridging. Five (30%) patients revealed mid-ventricular obstruction and intraventricular gradient was 25 ± 5 mmHg by the catheterization. All patients showed "giant" negative (? 10 mm) T waves in the precordial leads, whereas 2 patients had atrial fibrillation. Maximum wall thickness was measured as 18 ± 4 mm in the apical region by transthoracic echocardiography. One patient (5%) who had mid-ventricular obstruction developed atrial fibrillation during 2 years follow-up, though any other events did not occur during hospitalization or follow-up period. Conclusions: Physicians caring for patients with chest pain should consider AHCM in their differential diagnosis in case of a patient with chest pain and electrocardiographic changes suggestive of CAD. © Springer Science+Business Media, B.V. 2008.
  • Küçük Resim Yok
    Öğe
    Association between resistin level and renal function in patients undergoing coronary artery bypass graft surgery
    (BMJ Publishing Group, 2012) Gungor H.; Kirilmaz B.; Zorlu A.; Oguz E.; Fatih Ayik M.; Kumak F.; Zoghi M.
    Aim: The purpose of this study was to evaluate the association between resistin levels and renal function in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: Thirty-seven consecutive patients (mean T SD, age 60 T 10 years, 29 (78%) male) undergoing CABG surgery at our department were enrolled into our study. Blood samples were taken to examine quantities of resistin level and other blood parameters the day before surgery. The patients were categorized into 2 groups: lower resistin level (group 1) or higher resistin level (group 2) according to the median value of 9 ng/mL. Results: Mean T SD resistin level, glomerular filtration rate (GFR), and urea and creatinine levels were 9.5 T 4.2 ng/mL, 78 T 25 mL/min per 1.73 m2, 42 T 14 mg/dL, and 1.08 T 0.2 mg/dL, respectively. Resistin showed significant correlation with serum levels of urea (r = 0.448l P = 0.005), creatinine (r = 0.367; P = 0.026), inverse correlation with GFR (r =j0.398; P = 0.015), statin usage (r =j0.393; P = 0.016), and A-blocker usage (r = j0.365; P = 0.026). In the multivariate logistic regression model, only GFR (odds ratio, 0.960; 95 confidence interval, 0.928-0.993; P = 0.018) remained independently associated with higher resistin levels after adjustment of other potential confounders in patients undergoing CABG surgery. According to the receiver operating characteristics curve analysis, the optimal cutoff value of GFR to predict higher resistin levels was found as 91 mL/min or less per 1.73 m2, with 100% sensitivity and 61.1% specificity. Conclusion: The present study demonstrated that a lower glomerular filtration rate was associated with higher circulating resistin levels, independent of coronary heart disease risk factors in patients undergoing CABG surgery. Copyright © 2012 by The American Federation for Medical Research.
  • Küçük Resim Yok
    Öğe
    Bilateral renal arterial embolisation in a patient with mitral stenosis and atrial fibrillation: An uncommon reason of flank pain
    (2003) Yavuzgil O.; Gürgün C.; Zoghi M.; Tekin F.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Cardiac failure secondary to idiopathic hypoparathyroidism: A case report
    (2009) Özerkan F.; Güngör H.; Zoghi M.; Nalbantgil S.
    ypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition. Ensuing heart failure due to hypocalcemia is refractory to conventional treatment. We reported a 41-year-old man who developed cardiac fHailure due to hypocalcemia secondary to idiopathic hypoparathyroidism. Echocardiography showed biventricular low ejection fraction, dilated heart chambers, pulmonary hypertension, and valvular regurgitations. Serum calcium and parathyroid hormone levels were low. After treatment of heart failure and calcium-vitamin D supplementation, signs and symptoms of heart failure improved rapidly. At 6 months, biventricular systolic and diastolic functions returned to normal. Serum calcium level should be monitored in every patient with cardiac failure and hypocalcemia should be considered in patients with refractory heart failure.
  • Küçük Resim Yok
    Öğe
    Cardiac memory: Do the heart and the brain remember the same?
    (2004) Zoghi M.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Cardiovascular involvement in Behçet's disease
    (2002) Gürgün C.; Ercan E.; Ceyhan C.; Yavuzgil O.; Zoghi M.; Aksu K.; Cinar C.S.; Türkoglu C.
    The incidence and nature of cardiac involvement in Behçet's disease are not yet clearly documented. We first used transesophageal echocardiography in combination with resting and signal averaged electrocardiography to define cardiac involvement in Behçet's patients. Transthoracic and multiplane transesophageal echocardiography, and resting and signal averaged electrocardiography were performed in 35 Behçet's disease patients (9 women and 26 men, mean age: 38±12 years) and 30 normal subjects. Higher incidences of interatrial septum aneurysm (31% to 6%), mitral valve prolapse (25% to 3%), mitral regurgitation (40% to 6%) and aneurysmal dilatations of sinus valsalva and ascendan aorta were observed in the Behçet's disease patients than in the normal subjects. Mean QT dispersion and mean corrected QT dispersion values were significantly greater in the patients with Behçet's disease. Patients with interatrial septum aneurysm (and/or PFO), valvular dysfunction or proximal aorta dilatation had greater QT dispersion values than thase without these pathologies in the Behçet's group (63±11 vs 44±19 ms, 58±23 vs 41±24 and 60±27 vs 42±23 ms respectively, P<0.05). Positive signal averaged electrocardiography parameters were detected in 18 (51%) Behçet's disease patients compared with one (3%) in controls (P<0.001). Dilatation of the proximal aorta, interatrial septal aneurysm, mitral valve prolapse, and mitral regurgitation are the common findings of cardiac involvement in Behçet's disease. Increased dispersion of ventricular repolarisation and positive late potentials are also detected. QT dispersion is significantly higher in patients with these cardiac abnormalities. These findings suggest that cardiac involvement in this disorder is a diffuse process which involves both cardiac structure and vascular elements. Copyright © 2002 by the Japanese Heart Journal.
  • Küçük Resim Yok
    Öğe
    Changes in etiology, cause of death, survival, and mortality rates in cardiac transplant patients from 1998 to 2011 [1998-2011 arasi dönemde kalp nakli hastalarinda etyoloji, ölüm nedenleri, sagkalim ve mortalite oranlarindaki degişim]
    (2012) Güngör H.; Nalbantgil S.; Oguz E.; Ayik M.F.; Zoghi M.; Ertugay S.; Karakula S.; Engin Ç.; Yagdi T.; Özbaran M.
    Objectives: We retrospectively analyzed changes in heart failure etiology, causes of death, mortality and survival rates in cardiac transplant patients from 1998 to 2011. Study design: A total of 144 patients (112 men, 32 women; mean age 40.2±14.3 years) underwent cardiac transplantation between February 1998 and January 2011. The patients were divided into two groups; hence, 63 patients (group 1; mean age 42.5±12.6 years) receiving transplantation up to January 2006, and 81 patients (group 2; mean age 38.4±15.3 years) receiving transplantation from 2006 to 2011. In the latter period, a ventricular assist device was used in 17 patients before transplantation. Results: Dilated cardiomyopathy was the main cause of heart transplantation in both groups (71.4% vs. 74.1%). Overall mortality, in-hospital mortality (<30 days), and late mortality (?30 days) rates were 39.6% (n=57), 13.9% (n=20), and 25.7% (n=37), respectively. Survival rates for 1, 2, 5, and 10 years were 76%, 69%, 59%, and 46%, respectively. The second group had significantly lower rates of overall mortality and late mortality compared to group 1 (29.6% vs. 52.4%, p=0.005; 16.0% vs. 38.1%, p=0.002, respectively), whereas early mortality rates were similar. Survival rates were also higher in the second group, but these differences did not reach significance (1-year, 76.1% vs. 74.6%; 2-year, 73.0% vs. 65.1%; 5-year, 63.8% vs. 55.6%; log rank 0.33). In both groups, infections (30.3% vs. 33.3%), right ventricular failure (12.1% vs. 29.2%), and sudden cardiac death (15.2% vs. 16.7%) were the leading causes of death. Conclusion: Our data show that overall and late mortality rates show significant decreases in cardiac transplant patients from 1998 to 2011. © 2012 Türk Kardiyoloji Dernegi.
  • Küçük Resim Yok
    Öğe
    Changing face of heart failure surgery
    (2012) Yagdi T.; Oguz E.; Engin C.; Engin Y.; Nalbantgil S.; Zoghi M.; Ozbaran M.
    Background: Heart failure is a serious disease ending with death if untreated. Although heart transplantation is the best therapy for end-stage heart failure, most candidates die in the waiting period due to the lack of donor organs. This condition represent a new era of heart failure surgery. Methods: We retrospectively investigated 159 patients from 1998 to 2011 with a mean age of 40.0 years (range = 5-65), who were mostly diagnosed as dilated cardiomyopathy (n = 113). After April 2007, 67 patients underwent vascular assist device (VAD) implantation surgery for acute or chronic end-stage heart failure. We performed 69 heart transplantation with 27 on VAD systems before transplantation. Results: Early mortality was 13.3% with 21 patients after the heart transplantation. The 67 patients supported with VAD did not experience an intraoperative death. The mean support time was 214 days (range = 3-1035). Twenty-four patients (35.8%) are still on pump support. The overall survival until transplantation or weaning was 77.6% at mean of 250.7 days survival reached 90% with Heartware (Hartware Inc, Miramar, Fla, USA) continuous flow pumps. Conclusion: After the introduction of VAD in 2007, the overall picture has been restructured radically for heart failure surgery, reducing patient loss on the waiting list. Especially, since 2009 nearly 80% of donor hearts were used for patients on mechanical circulatory support. © 2012 Elsevier Inc. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Circadian and infradian rhythms of vasovagal syncope in young and middle-aged subjects
    (2008) Zoghi M.; Duygu H.; Gungor H.; Nalbantgil S.; Ozerkan F.; Akilli A.; Akin M.
    Background: The most cardiovascular physiological and pathophysiological events show a circadian rhythm. It is thought that the autonomic nervous system and biologic factors play a key role in the pathogenesis of vasovagal syncope (VVS). In this study, we investigated the circadian and infradian variation of VVS. Methods: A prospective consecutive series of 246 patients (142 women; mean age 36 ± 7 years) with recurrent syncope and with a positive head-up tilt testing (HUT) were included in this study. The daily and weekly distributions of the syncopal episodes were investigated. The assessments of episodes were done according to the days of the week and three time periods of the day (6 a.m.-12 noon, 12 noon-6 p.m., 6 pm-12 midnight). Results: According to the results of HUT, 76 patients (31%) had cardioinhibitory, 62 patients (25%) had vasodepressor, and 108 patients (44%) had mixed type of VVS. During the initial passive phase, 40% of patients (99/246) showed positive response. Time to syncope was 20 ± 2 minutes during HUT. The mean number of syncopal episodes was 4 ± 2/years. In all, 1,070 episodes were evaluated. The distribution of the episodes in 6-hour intervals was significantly different from uniform occurrence (38%, 33%, and 29%, respectively) (P = 0.02). The frequency of episodes was higher in the morning (P = 0.045) and in the middle of the week (P = 0.046). A significant difference was found between week and weekend days in terms of the frequency of episodes (75.5% vs 24.5%, P = 0.01). Conclusion: VVS may show a circadian and infradian rhythm. © 2008, The Authors.
  • Küçük Resim Yok
    Öğe
    Comparison of heart transplantation patients with ischemic and idiopathic dilated cardiomyopathy
    (2011) Gungor H.; Oguz E.; Ayik M.F.; Ertugay S.; Engin C.; Yagdi T.; Nalbantgil S.; Zoghi M.; Ozbaran M.
    We retrospectively analyzed our data to compare preoperative demographic, laboratory, echocardiographic, hemodynamic findings mortality and survival rates of heart transplantation patients with ischemic (ICM) and idiopathic dilated (IDCM) cardiomyopathy. The data of 144 patients transplanted from February 1998 to January 2011 were analyzed. 38 patients with ischemic ICM and 86 patients with IDCM were compared. Recipient age, preoperative creatinine, recipient body mass index, intraoperative cross-clamp time, donor male sex ratio, recipient male sex ratio, hyperlipidemia ratio, and previous nitrate use were significantly higher and left ventricular end systolic diameter significantly lower in patients with ICM. Major causes of death after heart transplantation were infections (31.9%), right ventricle failure (14.8%), and sudden cardiac death (14.8%). Causes of death were not different between the groups. Overall mortality in the entire population was 37.9% (47/124), and it was not different between the groups (39.5% vs 37.2%; P =.48). Early mortality (<30 days) rate was 11.2% (14/124), late mortality rate was 26.6% (33/124), and no statistically significant difference was observed between the groups. Survival analysis showed that ICM patients were not associated with worse survival compared with IDCM (71.1% vs 81.1% after 1 year, 68.1% vs 73.0% at 2 years, and 54.2% vs 62.3% at 5 years; log rank = 0.57). Multivariate analysis showed that the only predictor of mortality was preoperative urea level and that heart failure etiology was not a predictor of this end point. Patients with ICM had similar survival and mortality rate compared with IDCM. © 2011 Published by Elsevier Inc.
  • Küçük Resim Yok
    Öğe
    Comparison of ischemic side effects of levosimendan and dobutamine with integrated backscatter analysis
    (2009) Duygu H.; Nalbantgil S.; Zoghi M.; Ozerkan F.; Yildiz A.; Akilli A.; Akin M.
    Background: Levosimendan improves cardiac contractility without increasing oxygen consumption. However, its effects on ischemia were not supported with the utilization of a noninvasive parameter of myocardial characterization. Hypothesis: The changes observed in integrated backscatter (IBS) may be reflective of change in myocardial ischemia. In this study, the effect of levosimendan on ischemia detected by IBS was evaluated in patients with ischemic heart failure (HF). Methods: Patients who had LVEF <40% and NYHA III-IV symptoms of HF were included in this study. Patients were randomized to levosimendan (n = 21), or to dobutamine (n = 25) groups. The cyclic variation of integrated backscatter (CVIBS) was determined as the difference between the maximal and minimal values in a cardiac cycle, average of three consecutive beats. CVIBS was taken from the mid-anteroseptal, mid-inferior, and mid-posterolateral areas of the parasternal short axis images before the drug administration and at the end of the 24-hour infusion period. Results: Baseline characteristics and concomitant medications were similar in both groups. A significant reduction in CVIBS was detected in anteroseptal (7.6 ± 1.4 dB versus 5.9 ± 0.8 dB, p = 0.01), inferior wall (7.4 ± 0.8 dB versus 6.7±1.5 dB, p = 0.03), and posterolateral wall (9.0±1.2 dB versus 8.2 ± 0.6 dB, p = 0.04) after dobutamine administration, while no significant changes were observed in the levosimendan group in all walls. Conclusions: Unlike dobutamine, levosimendan may not induce myocardial ischemia as shown by CVIBS at commonly used dosages in the setting of decompensated HF without active ischemia. © 2009 Wiley Periodicals, Inc.
  • Küçük Resim Yok
    Öğe
    The determination of the factors impacting on in-hospital mortality in patients with acute heart failure in a tertiary referral center [Tersiyer bir merkezde akut kalp yetersizlikli hastalarda hastane içi mortaliteye etkili faktörlerin belirlenmesi]
    (2008) Zoghi M.; Duygu H.; Güngör H.; Nalbantgil S.; Yilmaz G.M.; Tülüce K.; Özerkan F.; Akilli A.; Akin M.
    Objective: Despite impressive advances in therapeutics in the last years, acute heart failure (AHF) remains a major cause of cardiovascular morbidity and mortality. Patients hospitalized because of heart failure (HF), irrespective of left ventricular systolic function, represent a high-risk population with limited short-term prognosis. A substantial component of HF-related mortality occurs during a hospital stay. In this study, we aimed to determine the factors impacting on in-hospital mortality in patients with AHF. Methods: During a 15-month period (December 2005-March 2007), 85 consecutive patients with (mean age: 64±8 years, male: 54%) an episode of AHF were included in this study. The effect of demographic, clinical, electrocardiographic, and electrocardiographic characteristics, laboratory findings on in-hospital mortality were evaluated retrospectively. Results: Of 85 patients 24.7% of patients had new-onset HF. Coronary artery disease (61%) was the most common underlying disease. The 44.7% of patients had hypertension, 37.6% had diabetes mellitus, 21% had chronic renal failure and 16.4% had chronic obstructive pulmonary disease. Left ventricular ejection fraction was 35±7%. In-hospital mortality rate was found as 11.7% (10 patients).The major cause of mortality was the progression of HF to cardiogenic shock in 60% of deaths. In comparison with surviving patients in terms of the clinical, demographic, electrocardiographic, and laboratory characteristics and left and right ventricular functions, patients died during hospitalization had higher blood urea nitrogen (45±20 mg/dl vs. 36±12 mg/dl, p=0.04), higher creatinine level (2.2±0.8 mg/ dl vs. 1.1±0.5 mg/dl, p=0.001), and wider QRS duration (130±13 ms vs. 116±18 ms, p=0.04) whereas they had lower plasma sodium level (128±5 mmol/l vs. 135±9 mmol/l, p=0.02) and systolic blood pressure (p=0.01). Logistic regression analysis revealed that plasma creatinine level (OR 1.5, 95% CI 1.2 to 2.1, p=0.01), blood urea nitrogen (OR 2.1, 85% CI 1.8 to 3.1, p=0.001), plasma sodium level (OR 1.3, 95% CI 1.1 to 1.7, p=0.02), and systolic blood pressure (OR 2.2, 95% CI 1.9 to 2.8, p=0.01) were the independent predictors of in-hospital mortality. Conclusion: In-hospital mortality increases in patients who had lower systolic blood pressure, lower plasma sodium level, and renal dysfunction on admission.
  • Küçük Resim Yok
    Öğe
    Diagnosis and management of acute heart failure [Akut kalp yetersizliği tanı ve tedavisi]
    (Turkish Society of Cardiology, 2015) Ural D.; Çavuşoğlu Y.; Eren M.; Karaüzüm K.; Temizhan A.; Yılmaz M.B.; Zoghi M.; Ramassubu K.; Bozkurt B.
    Acute heart failure (AHF) is a life threatening clinical syndrome with a progressively increasing incidence in general population. Turkey is a country with a high cardiovascular mortality and recent national statistics show that the population structure has turned to an 'aged' population. As a consequence, AHF has become one of the main reasons of admission to cardiology clinics. This consensus report summarizes clinical and prognostic classification of AHF, its worldwide and national epidemiology, diagnostic work-up, principles of approach in emergency department, intensive care unit and ward, treatment in different clinical scenarios and approach in special conditions and how to plan hospital discharge. © 2015 by Turkish Society of Cardiology.
  • Küçük Resim Yok
    Öğe
    Donor management in heart transplantation [Kalp transplantasyonunda donör bakimi]
    (2004) Yagdi T.; Nalbantgil S.; Engin C.; Zoghi M.; Özbaran M.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    Early atherosclerosis following heart transplantation: An intravascular ultrasonography study [Kalp transplantasyonu uygulanan hastalarda erken ateroskleroz: Bir i·ntravasküler ultrasonografik çalişma]
    (2004) Zoghi M.; Nalbantgil S.; Yagdi T.; Nart D.; Yavuzgil O.; Akilli A.; Akin M.; Özbaran M.
    There are several invasive and noninvasive techniques investigating the development of coronary artey disease following heart transplantation (TxCAD). This study attempts to investigate the extent of vasculopathy in heart transplant recipients by using intravascular ultrasonography (IVUS) compared to coronary angiography and to define the relationship between the rate of cellular rejection and intimal coronary thickness which is measured by IVUS. Our study is the first experience in Turkey. To investigate the extent of TxCAD, 18 heart transplant recipients were studied for 22±12 months after transplantation with intravascular ultrasound (IVUS). Dobutamine stress echocardiography (DES) and coronary angiography were performed in all patients. Coronary angiographically narrowing of more than 50% and intimal wall thickness >0.5mm detected by IVUS were defined as TxCAD. Biopsy score was considered as the average numerical value assigned to each grade of rejection divided by the total number of biopsies. According to the IVUS findings the patients were evaluated in two groups. There were 8 patients with TxCAD in group I, and group II consisted of 10 patients without TxCAD. The TxCAD was shown in 5.5% patients angiographically whereas this rate was 44% by IVUS. The results of DES were normal in all patients. The extent of coronary vessel wall alterations on ultrasound correlated with donor age (r=0.42, p=0.02), but not with perioperative ischemia time and other coronary artery risk factors (p>0.05). The intimal thickening was more pronounced in segments of the LAD than the other arteries (p<0.001). The value of biopsy score (the mean grade of rejection) demonstrated a correlation with the mean intimal thickening (r = 0.82, p = 0.01). Conclusion: 1) The rate of cellular rejection is an important factor for developing TxCAD. 2) IVUS is a more sensitive method for detection of TxCAD than coronary angiography.
  • Küçük Resim Yok
    Öğe
    Earthquakes and Cardiovascular Diseases
    (Galenos Publishing House, 2023) Zoghi M.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    The effect of combination therapy on regression of left ventricular hypertrophy in cases with hypertension
    (2004) Boydak B.; Nalbantgil S.; Yilmaz H.; Zoghi M.; Ozerkan F.; Nalbantgil I.; Onder R.
    Objective: Up to this date, it is well shown that several antihypertensive drugs have different regressive effect on left ventricular hypertrophy (LVH). However, there are different studies regarding the effect of antihypertensive combination therapies on regression of LVH. In this study, 2 different combinations ACE-I plus calcium channel blocker and ACE-I plus diuretic were compared in cases with hypertension whose BPs were not controlled by ACE-I alone. Methods: Forty patients with mild to moderate hypertension were included in this study. The treatment was continued for 6 months in the Faculty of Medicine at Ege University, Turkey, between January and December 2003. Adequate response with lisinopril 20mg/daily failed to be achieved in all patients. Patients divided into 2 groups. There were no differences between the groups in patients' age, blood pressure (BP) and other clinical and laboratory range. First group patients received lisinopril 20mg + nifedipine GITS 30mg and second group patients received lisinopril 20mg + hydrochlorothiazide 25mg. The treatment was continued for 6 months. Blood pressure were measured every 2 weeks, echocardiographic findings, and blood and urinary analysis were performed before and at the end of treatment. Results: Systolic and diastolic BP decreased significantly in both groups and no significant difference regarding BP was found between the 2 groups. Left ventricular mass index also decreased significantly in both groups. However, in the first group left ventricular mass index decreased more compared to the second group. Conclusion: The effect of combination therapies with angiotensin converting enzyme inhibitor (ACE-I) plus diuretic and ACE-I plus calcium channel blocker on systolic and diastolic BP are similar. However, when LVH is present, regressive effect of the combination of ACE-I plus calcium channel blocker is superior to the combination of ACE-I plus diuretic.
  • Küçük Resim Yok
    Öğe
    Effect of dyspnea and clinical variables on the quality of life and functional capacity in patients with chronic obstructive pulmonary disease and congestive heart failure
    (2008) Karapolat H.; Eyigor S.; Atasever A.; Zoghi M.; Nalbantgil S.; Durmaz B.
    Background: Chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) are two chronic diseases that affect negatively the functional condition and quality of life of patients. We assessed the effect of symptoms and clinical variables on the functional capacity and quality of life in COPD and CHF patients. Methods: The study included 42 COPD and 39 CHF patients. In both patient groups, dyspnea was assessed using Borg scale; functional capacity by shuttle-walk and cardiopulmonary exercise test and quality of life by short form-36 (SF36). Results: No statistically significant difference was found in neither of the two disease groups regarding the dyspnea score, shuttle-walk test and the majority of subgroup scores of SF36 (P>0.05). A statistically significant difference was observed in peak VO2 in favor of COPD group (P<0.05). No significant relationship was established between dyspnea score and forced expiratory volume in one second (FEV1) in COPD patients, and left ventricular ejection fraction (LVEF) in CHF patients (P>0.05). A significant negative correlation was observed between dyspnea score and functional capacity tests in both disease groups (P<0.05). On the other hand, no relationship was found between LVEF and FEV1 and quality of life and functional capacity (P>0.05). Conclusions: It was revealed that symptoms have an impact on functional capacity and quality of life in both disease groups, however, objective indicators of disease severity do not show a similar relationship. Therefore, in addition to the objective data related to the disease, we recommend that symptoms should also be taken into consideration to assess cardiopulmonary rehabilitation program and during following-up.
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