Yazar "Zihni, Figen Yargucu" seçeneğine göre listele
Listeleniyor 1 - 18 / 18
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of latent tuberculosis infection in Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test(Springer Heidelberg, 2010) Karadag, Omer; Aksu, Kenan; Sahin, Abdurrahman; Zihni, Figen Yargucu; Sener, Burcin; Inanc, Nevsun; Kalyoncu, Umut; Aydin, Sibel Zehra; Ascioglu, Sibel; Ocakci, Pinar Talu; Bilgen, Sule Apras; Keser, Gokhan; Inal, Vedat; Direskeneli, Haner; Calguneri, Meral; Ertenli, Ihsan; Kiraz, SedatA possible relationship between Takayasu arteritis (TA) and tuberculosis (TB) has been suggested. An increased frequency of tuberculin skin test (TST) was observed in TA patients. Quantiferon-TB Gold test (QFT) is a new in vitro assay measuring interferon-gamma response to M. tuberculosis antigens and helpful in diagnosing latent TB infection. The aim of this study was to investigate latent TB infection among TA patients by the use of both TST and QFT Gold test. Ninety-four (male/female: 7/87) TA patients fulfilling ACR 1990 TA criteria from three different university hospitals in Turkey and 107 control subjects without inflammatory diseases were included in the study. Data about medical history (TA and TB) were collected for both groups. TST and QFT were performed. TST values a parts per thousand yen5 mm for TA patients and a parts per thousand yen15 mm for controls was accepted as TST positivity. Even though TA group was older (40 +/- A 12 vs. 32 +/- A 8, P < 0.001), there was no significant difference between TA patients and controls regarding demographic characteristics. Six TA patients and one control had a history of previous TB infection (P = 0.054). Although TST positivity was higher in TA group [55 patients (62.5%) vs. 24 controls (41.4%), P = 0.008], QFT positivity was similar between two groups [21 patients (22.3%) vs. 24 controls (22.4%), P > 0.05]. QFT was negative in two of six TA patients with previous TB history. Rate of latent TB infection in TA patients measured with QFT is no more than controls. QFT seems to be a good and favorable test compared with TST in detecting LTBI in TA.Öğe Bilinen en eski çelişki(2019) Kara, Mete; Koçanaoğulları, Hayriye; Zihni, Figen Yargucu; Karabulut, GoncaPsoriatik artrit (PsA) aksiyal ve periferik eklemleri etkileyen, cilt, tırnak, entezis yerlerini tutabilen, psoriasis hastalarında görülebilen, klinik olarak heterojen bir hastalıktır. Bu nedenle de PsA birçok hastalık ile karışabilmektedir. Cilt tutulumu PsA hastalarının %15’inde eklem tutuluşundan sonra saptanabilmektedir. Bu da tanıda ve takipte zorluk yaratmaktadır. Periferik artrit ile başvuran ve anti siklik sitrüline peptit (anti-ccp) antikoru pozitif bir olgu ile PsA tanısının konulmasındaki zorluklara ve PsA’nın ayrıcı tanısını yapabilmek için de dikkatli ve detaylı bir anamnez ile iyi bir fizik muayene gerektiğine dikkat çekmeye çalıştık.Öğe Comments on the development of aortic structural damage (aneurysm or dilatation) in patients with giant cell arteritis.(2016) Keser, Gökhan; Tekeoğlu, Sanem; Zihni, Figen Yargucu; Aksu, Kenan…Öğe Comparison of non-COVID-19 critically ill patients between pre-pandemic and pandemic period admitted from emergency department to internal medicine intensive care unit(2024) Bozgul, Sukriye Miray Kilincer; Kurtulmus, Ilkce Akgun; Zihni, Figen Yargucu; Yilmaz, Mumtaz; Akarca, Funda Karbek; Aydoğan, Deniz Can; Ozkilic, BarisAim: During the COVID-19 pandemic, a large number of intensive care unit beds have been organized for critically ill COVID-19 patients. However, the need for intensive care for non-COVID-19 critical patients continues. In our study, we aimed to compare non-COVID-19 critically ill patients admitted to the internal medicine intensive care unit from the emergency department before and during the pandemic period. Materials and Methods: Patients who were admitted to the internal medicine intensive care unit from the emergency department were grouped as pre-pandemic (March 2018-March 2020) and during the pandemic (March 2020-March 2022) and compared retrospectively in terms of the number of hospitalisations, demographic characteristics, length of intensive care unit stay and mortality. Results: The number of emergency department patient admissions other than surgical reasons was 579.657 during the study period. 63.33 % of these patients were admitted before the pandemic and 36.67% during the pandemic period. The number of patients included in our study was 493 before the pandemic and 460 during the pandemic period. Median age was 61 (30) in the pre-pandemic period and 64 (26.8) in the pandemic period, p=0.022. There was no significant difference in terms of comorbidities. The main reason for hospitalization was similar and sepsis was the leading reason for hospitalization. The frequency of acute renal failure in intensive care unit was significantly higher during the pandemic period. Mortality was 25.2% before the pandemic and 24.3% during the pandemic period, p=0.760. Conclusion: Although emergency department admissions decreased, the number of non-COVID-19 internal medicine intensive care unit hospitalizations did not decrease. This situation reveals the importance of organizing intensive care beds for hospitalization for non-COVID-19 reasons in order not to disrupt health services during the pandemic period.Öğe Dermatomiyozit ve malignite birlikteliği: bir olgu örneği(2019) Tanıgör, Göksel; Koçanaoğulları, Hayriye; Zihni, Figen Yargucu; Karabulut, GoncaDermatomiyozit, hem kas, hem de derinin tutulduğu bir sistemik otoimmün hastalıktır. Hastaların önemli bir kısmında altta bir malignite varlığı tespit edilebilmektedir. Birliktelik genellikle solid organ tümörleri olmakla beraber birçok malign neoplazi ile ilişkili olabilir. Bu nedenle hastalarda sadece hastalık yönetiminin gerçekleştirilmesi değil, sistemik açıdan da detaylı bir şekilde taranması ve gelecekte de bu açıdan izlenmesi önemlidir. Sunulacak olgu bahsettiğimiz birlikteliğe bir örnek teşkil etmektedir.Öğe How Do Exercise, Sleep and Depression Affect Disease Scores and Quality of Life in Primary Sjögren's Syndrome Patients?(Dove Medical Press Ltd, 2024) Tastekin, Fatih; Karatas, Ezgi; Aydin, Ozgur; Zihni, Figen Yargucu; Kabasakal, Yasemin; Barutcuoglu, Burcu; Karabulut, GoncaPurpose: Primary Sj & ouml;gren's syndrome (PSS) has many effects such as fatigue, pain, physical activity limitation and sleep disturbance, which limit patient's daily and social lives. The aim of our study was to assess fatigue, depression, physical activity status and quality of life in patients with PSS, and to determine the relationship between these data and disease-related parameters. Patients and Methods: This study was conducted with 117 primary Sj & ouml;gren's syndrome patients. Demographic and anthropometric characteristics, disease activity (ESSDAI), quality of life scale (SF36), depression (Beck Depression Scale), physical activity status (International Physical Activity Questionnaire Short Form (IPAQ) score) and sleep status (Pittsburgh Sleep Quality Scale) of PSS patients were evaluated and relationships have been examined. Results: According to the results of our study, we found that sleep disorders are common in PSS patients (74.4%). Overweight patients, particularly higher lean mass sleep better (r:-0.201, p:0.043). Poor sleep causes fatigue (p=0.062) and depression (p=0.030). Sleep disturbance could not be explained by depressive state alone. However, after controlling for depression, the effect of sleep on fatigue seriously decreases (p=0.311). Exercise did not improve sleep quality (p=0.35) and the rate of poor sleep was higher among who exercised (p=0.192). Conclusion: Based on the results of our study, we believe that, treating depression in PSS patients is crucial for reducing fatigue. Patients need education on performing the correct exercises and weight gain should done in a professional manner. Gaining a deeper understanding of the multisystem involvement of the disease and the impact of exercise on the disease, will have positive effects on patient care and treatment decisions.Öğe İleri Yaştaki Bipolar Bozukluk Hastalarının Gereksinimlerinin Belirlenmesi(2021) Vahip, Simavi; Zihni, Figen Yargucu; Tunçel, Özlem Kuman[Abstract Not Available]Öğe Kanser immünoterapisi sırasında gelişen inflamatuvar artrit olgusu(2019) Şak, Tuncer; Karaca, Burçak; Zihni, Figen YargucuGünümüzde modern tıpta yaşanan teknolojik ve bilimsel gelişmeler solid ve hematolojik malignitelerin tedavisinde yeni tedavi stratejilerin ortaya çıkmasını sağlamıştır. Bu gelişmelerden biri de kanser immünoterapisi olarak adlandırılan ve ileri evre tümörlerin tedavisinde kullanılan İmmün Checkpoint İnhibitörleri’nin (İCİ) kullanımıdır. İCİ denen bu grup moleküller, kanser hücrelerinin T lenfosit başta olmak üzere doğal ve adaptif immünitenin efektör hücrelerinde bulunan koreseptörlerin aktivasyon veya inhibisiyonu ile bu hücreler tarafından öldürülmesini sağlayan monoklonal antikorlardır. Bununla birlikte kanser immünoterapisi, immünite hücreleri üzerindeki manüplasyonu nedeniyle self toleransı ortadan kaldırarak konağın sağlıklı hücrelerinin de hedef haline gelmesine ve bunlara karşı bir dizi immün reaksiyon başlamasına neden olabilmektedir. Biz de kanser immünoterapisi sırasında gelişen inflamatuvar artrit olgusunu sunmayı amaçladık.Öğe Letter to the editor: Heart involvement: A neglected manifestation of haemophagocytic syndrome associated with high mortality(W B Saunders Co-Elsevier Inc, 2024) Bozgul, Sukriye Miray Kilincer; Zihni, Figen Yargucu; Soyer, Akad; Bozkurt, Devrim[Abstarct Not Available]Öğe The Prevalence of Hypersensitivity Reactions to Antirheumatic Biological Agents and Results of the Skin Tests: Experience of a Tertiary Referral Allergy Center in Turkey(Bilimsel Tip Yayinevi, 2020) Dalgic, Ceyda Tunakan; Zihni, Figen Yargucu; Bulut, Gokten; Kokuludag, Ali; Sin, Aytul ZerrinObjective: The use of biological agents (BAs) has increased dramatically for inflammatory diseases and this increase has led to a rise in hypersensitivity reactions (HSRs). The symptoms and diagnostic tools for HSRs are not standardized. We aimed to analyze the prevalence of HSRs to anti-rheumatic BAs and to evaluate the usefulness of skin tests (STs) as a diagnostic tool. Materials and Methods: Our study was conducted at the Ege University Medical Faculty, Department of Internal Medicine, Division of Allergy and Clinical Immunology and Division of Rheumatology, Izmir, Turkey. Four hundred sixty patients who received BAs between Jan 1st, 2015, and Jan 1st, 2016, were reviewed in this retrospective cross-sectional study. The prevalence of HSRs was retrospectively evaluated. Ten patients with HSRs were evaluated with STs containing commercially available culprit drugs. The data was collected from hospital records. The age, sex, atopic diseases, primary rheumatic diseases, and anti-rheumatic therapies of the patients were recorded. Results: Two hundred fifty patients were treated with rituximab (RTX), 45 with infliximab, 40 with tocilizumab (TOC), 36 with golimumab, 35 with etanercept, 34 with abatacept, 15 with certolizumab, and 5 with adalimumab. Fifty reactions with RTX and two reactions with TOC were infusion-related (IRRs). Ten HSRs were observed. Eight patients had immediate (7 immediate systemic reactions and 1 local injection site reactions), and 2 had late-onset cutaneous reactions. We detected the ratio of IRRs as 11.3%, immediate HSRs as 1.73%, IgE-mediated reactions as 1.08%, and anaphylaxis as 0.86%. STs were positive in 5 of 8 patients with immediate HSRs. Four of them had anaphylaxis, and remarkably, 3 of these had positive STs. None of the ten patients had high levels of specific IgE and only four had atopic diseases. Total IgE levels were not high and specific IgE levels were not positive in the presence of HSR to BAs (p=0.039). Conclusion: Five of the 8 (62.5%) patients with immediate reactions had positive STs, which suggested IgE-mediated reactions. The prevalence of HSRs to BAs was less than the ones mentioned in the literature.Öğe The Prevalence of Hypersensitivity Reactions toAntirheumatic Biological Agents and Results of the SkinTests: Experience of a Tertiary Referral Allergy Center inTurkey(2020) Köklüdağ, Ali; Sin, Aytül Zerrin; Zihni, Figen Yargucu; Bulut, Gökten; Dalgıç, Ceyda TunakanObjective: The use of biological agents (BAs) has increased dramatically for inflammatory diseases and this increase has led to a rise in hypersensitivity reactions (HSRs). The symptoms and diagnostic tools for HSRs are not standardized. We aimed to analyze the prevalence of HSRs to anti-rheumatic BAs and to evaluate the usefulness of skin tests (STs) as a diagnostic tool. Materials and Methods: Our study was conducted at the Ege University Medical Faculty, Department of Internal Medicine, Division of Allergy and Clinical Immunology and Division of Rheumatology, Izmir, Turkey. Four hundred sixty patients who received BAs between Jan 1st, 2015, and Jan 1st, 2016, were reviewed in this retrospective cross-sectional study. The prevalence of HSRs was retrospectively evaluated. Ten patients with HSRs were evaluated with STs containing commercially available culprit drugs. The data was collected from hospital records. The age, sex, atopic diseases, primary rheumatic diseases, and anti-rheumatic therapies of the patients were recorded.Results: Two hundred fifty patients were treated with rituximab (RTX), 45 with infliximab, 40 with tocilizumab (TOC), 36 with golimumab, 35 with etanercept, 34 with abatacept, 15 with certolizumab, and 5 with adalimumab. Fifty reactions with RTX and two reactions with TOC were infusion-related (IRRs). Ten HSRs were observed. Eight patients had immediate (7 immediate systemic reactions and 1 local injection site reactions), and 2 had late-onset cutaneous reactions. We detected the ratio of IRRs as 11.3%, immediate HSRs as 1.73%, IgE-mediated reactions as 1.08%, and anaphylaxis as 0.86%. STs were positive in 5 of 8 patients with immediate HSRs. Four of them had anaphylaxis, and remarkably, 3 of these had positive STs. None of the ten patients had high levels of specific IgE and only four had atopic diseases. Total IgE levels were not high and specific IgE levels were not positive in the presence of HSR to BAs (p=0.039). Conclusion: Five of the 8 (62.5%) patients with immediate reactions had positive STs, which suggested IgE-mediated reactions. The prevalence of HSRs to BAs was less than the ones mentioned in the literature.Öğe Psoriatik artritin tedavisinde yeni ilaçların karşılaştırması(2019) Zihni, Figen YargucuPsoriatik artrit (PsA), periferik artrit, spondilit, entezit, daktilit, deri ve göz tutulumu, metabolik sendrom ve kardiovasküler iskemik hastalıklar gibi sistemik özelliklerin olduğu artiküler ve ekstraartiküler klinik belirtilerle karakterize bir hastalıktır. Farklı klinik belirtileri olan bir hastalık olduğu için PsA’te klinik belirtilere göre farklı tedavi kombinasyonlarının saptanmasına ihtiyaç vardır. Heterojen bir hastalık olan PsA’te tedavi kişiselleştirilmelidir.Öğe Retrospective review of the clinical and laboratory data in silent lupus nephritis(Springer, 2022) Zihni, Figen Yargucu; Karabulut, Gonca; Oksel, FahrettinPurpose To determine the ratio of renal disease necessitating immunosuppressive treatment in lupus patients who are clinically asymptomatic by means of renal disease. It was also examined whether silent lupus nephritis is associated with any of the non-renal clinical findings. Methods All kidney biopsies performed in lupus patients between 1990 and 2009 at the Rheumatology Department of Ege University Faculty of Medicine were retrospectively screened. Among the 258 kidney biopsies screened, 54 had no clinical renal findings but had active disease together with anti-dsDNA positivity and/or hypocomplementemia. Patients were classified into two groups who require and do not require immunosuppressive therapy according to their final pathological results at biopsy. The frequency of serious renal involvement in the sample was calculated. Then subgroups were compared with each other in terms of the clinical and laboratory features using Statistical Package for Social Sciences version 13 software. Results Thirteen of the 54 patients (24%) had severe renal involvement requiring immunosuppressant therapy. When the groups were compared to each other, it was found that serositis and hematologic involvement were significantly more frequent in patients who needed immunosuppressive treatment (42.9% versus 10.0%; p = 0.003 and 64.3% versus 37.5; p = 0.039). Conclusion Even in the absence of clinical renal manifestations, active patients at high risk of renal disease such as hypocomplementemia, anti-ds DNA positivity may have severe renal disease requiring immunosuppressive treatment. Thus, renal biopsy indications in lupus patients should better be revaluated.Öğe Romatizmal hastalıklarda karıştırıcı faktör olarak fibromyalji(2019) Taş, Mehmet Nedim; Zihni, Figen Yargucu; Oksel, FahrettinFibromiyalji (FM) yorgunluk, kognitif bozukluk, psikiyatrik semptomlar ve çoklu somatik semptomların eşlik ettiği kronik yaygın kas-iskelet ağrısının başlıca nedenlerinden biridir. FM yaygın olarak romatizmal hastalıklara eşlik edebilmekle birlikte, bazen de romatizmal hastalıkları taklit ederek yanlış tanılara yol açabilmektedir. FM’nin tanısı için dikkatli alınmış bir öykü ve detaylı fizik muayene gerekmektedir, hastalığın tanısı için özgül bir laboratuvar testi veya radyolojik görüntüleme yöntemi yoktur. Bu yazıda diffüz idiopatik skeletal hiperostozis (DISH) ve belirlenemeyen bağ doku hastalığına (BDH) eşlik eden, tanı ve tedavi sürecinde güçlük yaşanan bir FM olgusunu sunarak, romatizmal hastalıklara sıklıkla eşlik edebilen FM hastalığına dikkat çekmek istedik.Öğe Stroke presenting with an isolated foot drop in a patient with antiphospholipid syndrome: an uncommon clinical entity(Springer-Verlag Italia Srl, 2019) Tanigor, Goksel; Karabulut, Gonca; Celebisoy, Nese; Eraslan, Cenk; Zihni, Figen YargucuÖğe Therapy resistant idiopathic scleredema: an underlying pathology not always present(2015) Kalfa, Melike; Koçanaoğulları, Hayriye; Zihni, Figen Yargucu; Karabulut, Gonca; Emmungil, Hakan; İnal, VedatScleredema is a rare connective tissue disorder of unknown pathogenesis. Three types of scleredema have been described, based on its association with postinfection, monoclonal gammopathy and diabetes mellitus. We report herein a case of scleredema which the diagnosis didn't get specified. the patient was followed regularly for 13 years and did not respond to various combinations of immunosuppressants and psoralen plus ultraviolet A therapy. Treatment of scleredema is quite difficult and of limited success. At present, there is no proved treatment for this diseaseÖğe Therapy resistant idiopathic scleredema: an underlying pathology not always present(Aves, 2015) Kalfa, Melike; Kocanaogullari, Hayriye; Zihni, Figen Yargucu; Karabulut, Gonca; Emmungil, Hakan; Inal, VedatScleredema is a rare connective tissue disorder of unknown pathogenesis. Three types of scleredema have been described, based on its association with postinfection, monoclonal gammopathy and diabetes mellitus. We report herein a case of scleredema which the diagnosis didn't get specified. The patient was followed regularly for 13 years and did not respond to various combinations of immuno-suppressants and psoralen plus ultraviolet A therapy. Treatment of scleredema is quite difficult and of limited success. At present, there is no proved treatment for this disease.Öğe Thiopurine S-Methyltransferase Levels in Patients with Behcet's Disease.(Wiley-Blackwell, 2012) Emmungil, Hakan; Kalfa, Melike; Durusoy, Raika; Zihni, Figen Yargucu; Keser, Gokhan; Aksu, Kenan
