Yazar "Yurtseven, Mine" seçeneğine göre listele
Listeleniyor 1 - 12 / 12
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Constructive effect of exogenous melatonin against osteoporosis after ovariectorny in rats(Sci Printers & Publ Inc, 2007) Uslu, Serap; Uysal, Ayseguel; Oektem, Guelperi; Yurtseven, Mine; Tanyalcin, Tijen; Basdemir, GuelcinOBJECTIVE: To analyze histomorphometric, densitometric and biochemical effects of melatonin on osteoporosis in ovariectomized rats. STUDY DESIGN: Wistar rats were divided into 6 groups. Group C: control; Group I: bilateral ovariectomy (OVX); Group II. OVX + vehicle; Group III: OVX + 10 mg/kg/day melatonin WLT); Group IV. OVX + 30 mg/kg/day MLT; Group V. sham + 10 mg/kg/day MLT. Cortex, trabecula, osteoblast and osteoclast numbers were evaluated on vertebra and femur histomorphometrically. Hydroxyproline analysis was used to determine collagen content of femur and vertebrae. Bone mineral density and bone mineral content were measured. RESULTS: Trabecular thickness and trabecular area of vertebra and femur and cortical thickness of femur showed remarkable decrease after OVX, but increased after MLT treatment in the OVX+MLT groups. Following OVX, no statistically significant difference was found in number of osteoblasts or osteoclasts, trabecular number or levels of hydroxyproline after treatment with MLT. OVX caused significant decrease in bone mineral density, but treatment with MLT was unable to reverse this effect. CONCLUSION: MLT may trigger microscopic changes in bone, and time of application is critical for clinical recovery. It can be effective in helping treat postmenopausal osteoporosis. However, it is contraindicated in women who have normal-functioning ovaries.Öğe Efficacy of melatonin on offspring liver maturation in pinealectomized pregnant rats subjected to experimental epilepsy(Blackwell Publishing, 2007) Ates, Utku; Baka, Meral; Uyanikgil, Yigit; Turgut, Mehmet; Yavasoglu, Altug; Yurtseven, MineBackground and Aims: In clinical practice, maternal epilepsy is a disabling disease for newborn infants, but current data concerning the effect of epileptic phenomena in pregnant mothers on newborns are still limited. This study was undertaken to investigate the effects of pinealectomy (Px) and melatonin treatments on the morphological changes in the liver tissue of newborn rats following experimental epilepsy during pregnancy. Methods: Female Swiss Albino rats were divided into five groups: intact control group; saline control group; epilepsy group; epilepsy plus Px group; and melatonin-treated epilepsy plus Px group. At one month after Px, an acute grand mal epileptic seizure was induced by penicillin-G during their pregnancy in all animals except the control groups. On the neonatal first day, newborn rats were perfused with intracardiac fixative solution, and then livers were removed and processed for toluidine blue, periodic acid-Schiff (PAS) and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) reactivity. Results: Normal migration and hepatic maturation were determined in the postnatal rat liver in the control groups, while the morphological structure of the liver in the epilepsy and epilepsy plus Px groups corresponded to the early embryonic period. In the melatonin-treated epilepsy plus Px group, the number of TUNEL positive cells decreased significantly compared to both epilepsy and epilepsy plus Px groups; however, there was no statistically significant difference from the control groups as a result of melatonin activity. Conclusions: Some histological findings consistent with chronic fetal distress in newborns of mother rats with epilepsy and Px were observed. Melatonin could be a candidate protective drug for the development of liver tissue in pregnant patients with epilepsy.Öğe Light, electron microscopic and immunohistochemical study of the effect of low-dose aspirin during the proestrus phase on rat endometrium in the preimplantation period(Sci Printers & Publ Inc, 2007) Ates, Utku; Baka, Meral; Turgut, Mehmet; Uyanikgil, Yigit; Ulker, Sibel; Yilmaz, Ozlem; Tavmergen, Erol; Yurtseven, MineOBJECTIVE: To evaluate structural alterations in rat endometrium at preimplantation following treatment with aspirin beginning from proestrus by light microscopy, electron microscopy and immunohistochemical techniques. STUDY DESIGN: Twenty rats were divided into control (n =10) and experimental (n =10) groups. Experimental rats were treated with low-dose aspirin daily (2 mg/kg/day) during estrus, beginning from the proestrus phase, mated at end of cycle and treated with aspirin. Untreated pregnant rats were the control group. Rats in both groups were sacrificed at the 84th pregnancy hour; the uterus was rapidly removed and dissected free of surrounding adipose tissue. Uteri specimensfrom nonpregnant rats were transferred into fixative solution and processed for light, electron microscopic and immunohistochemical study. RESULTS: Light and electron microscopy of endometrium from control rats conformed to mid-diestrus phase; endometrial histology of the aspirin-treated group conformed to late diestrus phase. The endometrial layer was significantly thicker in the aspirin-treated group compared to the untreated control group (p < 0.001). No significant difference was found in vessel number between groups. Staining with alpha V integrin was more dense in the aspirin-treated group. CONCLUSION: Based on histologic findings, we suggest low-dose aspirin has positive effects on preparing endometrium before implantation.Öğe Maternal thyrotrophin releasing hormone TRH administration accelerates maturation in fetal rat lung A morphologic study by electron microscopy(2000) Vatansever, Seda; Laçin, S; Özbilgin, Kemal; Uysal, Ayşegül; Çağlar, H; Koyuncu, F; Yurtseven, Mine…Öğe Retinol asetat uygulanmasının yenidoğan sıçan akciğerinde doza bağımlı olarak oluşturduğu morfolojik değişiklikler(2002) Öktem, Gülperi; Aktuğ, Hüseyin; Yurtseven, Mine; Uysal, Ayşegül; Vatansever, Seda…Öğe Sıçanlarda n oculomotoriusun sinus cavernosus içindeki bölümünün elektron mikroskopik yapısı(1997) Yurtseven, Mine; Baka, Meral; Uysal, Ayşegül; Cireli, Erdoğan; Köktürk, İsmet…Öğe Sıçanlarda nervus hypoglossusun ultrastrukturel yapısının incelenmesi(1997) Baka, Meral; Uysal, Ayşegül; Yurtseven, Mine; Cireli, Erdoğan; Köktürk, İsmet…Öğe Sıçanlarda sinus cavernosus içinde seyreden nervus abducense ait myelinli ve myelinsiz aksonların ultrastrüktürel incelenmesi(1996) Uysal, Ayşegül; Yurtseven, Mine; Baka, Meral; Cireli, Erdoğan; Köktürk, İsmetSinus cavernosus içinde seyreden n. abducense ait myelinli ve myelinsiz aksonların ultrastrüktürel yapısı sıçanlarda araştırıldı. Alınan parçaları Caulfield fiksatifi üe tespit edildi ve rutin elektron mikroskop takibinden sonra değerlendirilmesi yapıldı. N. abducensin tipik olarak kalın myelinli ve büyük çaplı aksonlanyla beraber orta ve küçük çaplı myelinli aksonları saptandı. Postganglioner sempatik bağlantıya ait myelinsiz aksonlar oblik veya longitudinal olarak ayırdedildi. Myelinli aksonların aralarında, tek başına veya küçük gruplar halinde Schwann hücresi içine gömülü transvers myelinsiz aksonlar bulundu. Tüm aksonların myelin, aksoplasma içerikleri ve Schwann hücrelerine ait ultrastrüktürel özellikleri saptanarak literatür bilgileri ile tartışılması yapıldı.Öğe Sıçanlarda sinus cavernosus içinde seyreden nervus abducense ait myelinli ve myelinsiz aksonların ultrastrüktürel incelenmesi(1996) Uysal, Ayşegül; Yurtseven, Mine; Baka, Meral; Cireli, Erdoğan; İsmet, Köktürk…Öğe Türk toplum bireylerinde göz bölgesi norma varyasyonlarının morfolojik ve antropolojik değerlendirilmesi(1989) Cireli, Erdoğan; Yurtseven, Mine; Uysal, Ayşegül; Özoğul, Candan…Öğe Ultrastructural changes of the thymic epithelial reticular cell in young female rats after administration of testosterone(2000) Yurtseven, Mine; Uysal, Ayşegül; Aktuğ, Hüseyin; Yavaşoğlu, Altuğ; Ateş, Utku…Öğe Yüksek doz maternal vitamin A Retinol Asetat uygulamasına bağlı olarak neonatal sıçanlarda böbrek korteksinin ışık ve elektron mikroskobik olarak incelenmesi(2002) Aktuğ, Hüseyin; Akdede, Naime; Yurtseven, Mine; Uysal, Ayşegül; Uslu, Serap; Öktem, Gülperi…
