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    Epicardial fat, body mass index, and triglyceride are independent contributors of serum fibroblast growth factor 21 level in obese premenopausal women
    (Springer, 2015) Akyildiz, Z. I.; Polat, S.; Yurekli, B. S.; Kocabas, G. U.; Tuluce, K.; Tuluce, S. Y.; Kocabas, U.; Bozkaya, G.; Yuksel, A.; Nazli, C.
    Purpose The hormone fibroblast growth factor 21 (FGF-21) regulates carbohydrate and lipid homeostasis. FGF-21 represents an attractive novel therapy for obesity since administration of FGF-21 has been shown to improve metabolic abnormalities in obese animal models. We investigated FGF-21 and its relationship with epicardial fat thickness (EFT), metabolic parameters, and inflammatory markers in premenopausal obese women compared to controls with similar Systematic Coronary Risk Evaluation (SCORE) project risk profiles. Methods Forty-five obese premenopausal women with body mass index (BMI) >= 30 kg/m(2) and 41 control premenopausal women with BMI <25 kg/m(2) with similar SCORE project risk profiles were included in this case-control study. EFT was evaluated by two-dimensional transthoracic echocardiography. Serum FGF-21 was measured with an ELISA kit. Results FGF-21 and EFT were significantly higher in obese women compared to controls (p < 0.001). Multiple stepwise linear regression analysis showed that EFT, BMI, and triglycerides (TG) independently contributed to FGF-21 (R-2 = 0.757, p < 0.001). However, homeostasis model assessment of insulin resistance (HOMA-IR), visceral ectopic fat, and inflammatory markers were not found as a direct contributor to serum FGF-21 level (p > 0.05). Conclusions EFT, BMI, and TG may play an important role in predicting serum FGF-21 level which may be a potential therapeutic target in cardiometabolic disorders in the future.
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    Fetuin-B levels in relation to metabolic/hormonal profile and carotid intima media thickness (cIMT) in women with polycystic ovary syndrome (PCOS)
    (Springer, 2016) Senses, P. Yesil; Senses, Y. M.; Kocabas, G. Unal; Calan, O. Gursoy; Imamoglu, C.; Bilgir, O.; Yuksel, A.; Bozkaya, G.; Calan, M.
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    The level of the neudesin in type-2 diabetic patients and the relationship between the metabolic parameters and carotid intima-media thickness
    (NLM (Medline), 2023) Karatas, O.; Calan, M.; Yuksel, A.; Chousein, R.; Bozkaya, G.; Karatas, M.; Uslu, A.
    BACKGROUND: Neudesin is a protein that is secreted from adipose tissue and central nervous system and has a regulatory function on energy metabolism. Although the effect of this protein is shown in the experimental model of type-2 diabetes mellitus (type-2DM), its effect in humans is not clearly known. In this study, we aimed to evaluate the relationship between serum neudesin level and metabolic, anthropometric and cardiovascular parameters in newly diagnosed type-2DM patients (group 1). METHODS: Forty patients in each were included in our study for group 1 and for the control group (group 2), which consisted of age and sex-matched healthy subjects. Serum neudesin, hs-CRP, carotid intima media thickness (CIMT), Body Mass Index (BMI) and insulin resistance (HOMA-IR) levels were compared prospectively. RESULTS: Serum neudesin levels were significantly higher in diabetic patients than in the control group (type-2DM: 64.69±3.06 ng/mL, control: 55.52±5.48 ng/mL, P=0.004*). There was an independent relationship between serum neudesin and HOMA-IR and BMI. Although there is a correlation between serum neudesin and CIMT; this feature disappeared in the regression analysis. CONCLUSIONS: Serum neudesin increased in new diagnosis type-2DM patients. This increase seems to be related to obesity and insulin resistance. However, more extensive research is needed to clarify this issue.