Yazar "Yoltaş A." seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Development and characterization of voriconazole loaded in situ gel formulations for ophthalmic application [Oküler uygulama için vorikonazol yüklü in situ jel formülasyonlarının geliştirilmesi ve karakterizasyonu]
    (Turkish Pharmacists Association, 2016) Üstündağ Okur N.; Yoltaş A.; Yozgatli V.
    The aim of the this research was to prepare and evaluate the potential use of in situ gel formulations for ocular delivery of voriconazole for the treatment of fungal keratitis. An in situ gelling system was used to increase the residence time and thus the bioavailability of voriconazole in ocular mucosa. Temperature triggered in situ gel formulations were prepared by cold method using polymers like poloxamer 188, poloxamer 407 and sodium alginate. Finally, concentration of voriconazole in formulations was 0.1% (w/w). These formulations were evaluated for clarity, sol-gel transition temperature, gelling capacity, pH, viscosity and drug content. The gelation temperatures of all the formulations were within the range of 32-34°C. All the formulations exhibited fairly uniform drug content. Furthermore in vitro drug release and antifungal activity of these formulations were also evaluated. Drug release study of all the formulations showed sustained release properties. In conclusion, voriconazole loaded in situ gels could be offered as a promising strategy for ocular drug delivery for the treatment of fungal keratitis. © 2016, Turkish Pharmacists Association. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Evaluation of the antidiabetic property of Capparis ovata desf. Var. Palaestina Zoh. extracts using in vivo and in vitro approaches
    (Bentham Science Publishers B.V., 2018) Okur M.E.; Polat D.Ç.; Özbek H.; Yılmaz S.; Yoltaş A.; Arslan R.
    Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced diabetic BALB-c mice were administered intraperitoneally with 100, 300, 500mg/kg doses of ethanol and aqueous extracts of buds and fruits. Furthermore, HPLC, phenolic and flavonoid compounds analysis, ABTS and DPPH free radical scavenging activity, anti-inflammatory activity, agar well diffusion and MIC tests were carried out. Results: Fruit-aqueous; 100mg/kg, 300mg/kg and bud-aqueous; 500mg/kg extracts showed significant hypoglycemic activity. All extracts indicated important antioxidant activity, however, bud-aqueous extract demonstrated the most potent activity. HPLC study exhibited that rutin is found in high amounts in bud-aqueous and bud-ethanol extracts. Furthermore, the bud-aqueous extract depicted stronger and broader antimicrobial activity than other extracts. Fruit-ethanol and bud-ethanol extracts denoted the most potent anti-inflammatory effect even though this effect was significantly shown by all extracts. Finally, high levels of phenolic and flavonoid content were involved in all extracts, but the highest levels were found in fruit-ethanol and bud-ethanol extracts. Conclusion: The results showed that extracts which indicated hypoglycemic, antioxidant, anti-inflammatory, antimicrobial activities may provide a valuable contribution to the management of diabetes and its complications. © 2018 Bentham Science Publishers.
  • Küçük Resim Yok
    Öğe
    A novel approach for skin infections: Controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazole
    (Editions de Sante, 2018) Üstündağ Okur N.; Filippousi M.; Okur M.E.; Ayla Ş.; Çağlar E.; Yoltaş A.; Siafaka P.I.
    The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal infections. In this study, VRZ embedded in a polymeric matrix composed of biocompatible poly(lactic acid) (PLA) and poly(ethylene succinate) (PESu). The mats were prepared via solvent evaporation and fully characterized by Fourier-Transformed Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), in vitro hydrolysis and release studies. The prepared blends defined as immiscible by DSC and SEM while FTIR spectroscopy did not disclose noticeable interactions between the polymers. It was found that hydrolysis was improved by increasing PESu content into the blend. VRZ loaded blends spectra exhibit slight differentiation compared to neat blends while the absence of VRZ melting peak, as DSC illustrated, indicated drug amorphization. Lastly, in vitro release studies depicted a controlled release pattern dependent on mats' hydrolysis degree. An improved antifungal activity of mats was detected by disc diffusion method against various microorganisms. Ex vivo studies of VRZ did not determine high permeation while histopathology results using mice were profitable. The irritation experiments displayed that the mats did not induce any skin irritation. © 2018