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Active immunotherapy for cancer patients using tumor lysate pulsed dendritic cell vaccine: a safety study
(Apsit Assoc Prom Stud Immunol Tumor, 2007) Ovali, E.; Dikmen, T.; Sonmez, M.; Yilmaz, M.; Unal, A.; Dalbasti, T.; Kuzeyli, K.; Erturk, M.; Omay, S. B.
Cancer vaccine therapy represents a promising therapeutical option. Consistently, with these new treatment strategies, the use of dendritic cell vaccines is becoming increasingly widespread and currently in the forefront for cancer treatment. The purpose of this study was to evaluate the feasibility and safety of tumor lysate-pulsed dendritic cell (DC) vaccine in patients with advanced cancers. For this purpose, eighteen patients with relapsed or refractory cancer were vaccinated with peripheral monocyte-derived DCs generated with GM-CSF and IL-4, and pulsed consequently with 100 mu g/ml of tumor lysate before maturation in culture in the presence of IL-1 beta, PGE(2) and TNF alpha for two days. The first two vaccinations were given intradermally every two weeks while further injections were given monthly. Tumor lysate-pulsed dendritic cell injections were well-tolerated in all patients with no more than grade I injection-related toxicity. Local inflammatory response was mainly erythematous which subsided in 48 hrs time. No end organ toxicity or autoimmune toxicity was identified. Clinical responses observed in our study were satisfactory for a phase I clinical study. We observed 4 (22%) objective clinical responses. These responses are significantly correlated with delayed type hypersensitivity testing (DTH) (p < 0.01). The results showed that this active immunotherapy is feasible, safe, and may be capable of eliciting immune responses against cancer.
BRAF GENE MUTATIONS AND PROGNOSTIC SIGNIFICANCE OF CLINICAL FINDINGS IN CASTLEMAN DISEASE
(Ferrata Storti Foundation, 2016) Turker, M.; Subari, S.; Keklik, M.; Dal, M. S.; Sahin, N.; Comert, M.; Alanoglu, G.; Kara, E.; Kocarslan, S.; Gundogan, E.; Buyukbayram, H.; Ayyildiz, O.; Unal, A.; Oztuzcu, S.; Akpolat, N.; Saydam, G.; Bircan, S.; Demir, C.; Sari, I.; Yilmaz, M.
Clinical and genetic heterogeneity of hyper IgE syndrome in a Turkish cohort
(Wiley-Blackwell Publishing, Inc, 2008) Keles, S.; Karakoc-Aydiner, E.; Ozdemir, C.; Reisli, I; Camcioglu, Y.; Somer, A.; Kutukculer, N.; Yegin, O.; Yilmaz, M.; Kucukosmanoglu, E.; Genel, F.; Baki, A.; Bahceciler, N. N.; McGhee, S.; Chatila, T.; Barlan, I. B.
The clinical features, diagnosis, treatment, and prognosis of neuroinvasive listeriosis: a multinational study
(Springer, 2015) Arslan, F.; Meynet, E.; Sunbul, M.; Sipahi, O. R.; Kurtaran, B.; Kaya, S.; Inkaya, A. C.; Pagliano, P.; Sengoz, G.; Batirel, A.; Kayaaslan, B.; Yildiz, O.; Guven, T.; Turker, N.; Midi, I.; Parlak, E.; Tosun, S.; Erol, S.; Inan, A.; Oztoprak, N.; Balkan, I.; Aksoy, Y.; Ceylan, B.; Yilmaz, M.; Mert, A.
The aim of this study was to determine the independent risk factors, morbidity, and mortality of central nervous system (CNS) infections caused by Listeria monocytogenes. We retrospectively evaluated 100 episodes of neuroinvasive listeriosis in a multinational study in 21 tertiary care hospitals of Turkey, France, and Italy from 1990 to 2014. The mean age of the patients was 57 years (range, 19-92 years), and 64% were males. The all-cause immunosuppression rate was 54 % (54/100). Forty-nine (49 %) patients were referred to a hospital because of the classical triad of symptoms (fever, nuchal rigidity, and altered level of consciousness). Rhombencephalitis was detected radiologically in 9 (9 %) cases. Twenty-seven (64 %) of the patients who had cranial magnetic resonance imaging (MRI) performed had findings of meningeal and parenchymal involvement. The mean delay in the initiation of specific treatment was 6.8 +/- 7 days. Empiric treatment was appropriate in 52 (52 %) patients. The mortality rate was 25 %, while neurologic sequelae occurred in 13 % of the patients. In the multivariate analysis, delay in treatment [odds ratio (OR), 1.07 [95 % confidence interval (CI), 1.01-1.16]] and seizures (OR, 3.41 [95 % CI, 1.05-11.09]) were significantly associated with mortality. Independent risk factors for neurologic sequelae were delay in treatment (OR, 1.07 [95 % CI, 1.006-1.367]) and presence of bacteremia (OR, 45.2 [95 % CI, 2.73-748.1]). Delay in the initiation of treatment of neuroinvasive listeriosis was a poor risk factor for unfavorable outcomes. Bacteremia was one of the independent risk factors for morbidity, while the presence of seizures predicted worse prognosis. Moreover, the addition of aminoglycosides to ampicillin monotherapy did not improve patients' prognosis.
The clinical features, diagnosis, treatment, and prognosis of neuroinvasive listeriosis: a multinational study
(Springer, 2015) Arslan, F.; Meynet, E.; Sunbul, M.; Sipahi, O. R.; Kurtaran, B.; Kaya, S.; Inkaya, A. C.; Pagliano, P.; Sengoz, G.; Batirel, A.; Kayaaslan, B.; Yildiz, O.; Guven, T.; Turker, N.; Midi, I.; Parlak, E.; Tosun, S.; Erol, S.; Inan, A.; Oztoprak, N.; Balkan, I.; Aksoy, Y.; Ceylan, B.; Yilmaz, M.; Mert, A.
The aim of this study was to determine the independent risk factors, morbidity, and mortality of central nervous system (CNS) infections caused by Listeria monocytogenes. We retrospectively evaluated 100 episodes of neuroinvasive listeriosis in a multinational study in 21 tertiary care hospitals of Turkey, France, and Italy from 1990 to 2014. The mean age of the patients was 57 years (range, 19-92 years), and 64% were males. The all-cause immunosuppression rate was 54 % (54/100). Forty-nine (49 %) patients were referred to a hospital because of the classical triad of symptoms (fever, nuchal rigidity, and altered level of consciousness). Rhombencephalitis was detected radiologically in 9 (9 %) cases. Twenty-seven (64 %) of the patients who had cranial magnetic resonance imaging (MRI) performed had findings of meningeal and parenchymal involvement. The mean delay in the initiation of specific treatment was 6.8 +/- 7 days. Empiric treatment was appropriate in 52 (52 %) patients. The mortality rate was 25 %, while neurologic sequelae occurred in 13 % of the patients. In the multivariate analysis, delay in treatment [odds ratio (OR), 1.07 [95 % confidence interval (CI), 1.01-1.16]] and seizures (OR, 3.41 [95 % CI, 1.05-11.09]) were significantly associated with mortality. Independent risk factors for neurologic sequelae were delay in treatment (OR, 1.07 [95 % CI, 1.006-1.367]) and presence of bacteremia (OR, 45.2 [95 % CI, 2.73-748.1]). Delay in the initiation of treatment of neuroinvasive listeriosis was a poor risk factor for unfavorable outcomes. Bacteremia was one of the independent risk factors for morbidity, while the presence of seizures predicted worse prognosis. Moreover, the addition of aminoglycosides to ampicillin monotherapy did not improve patients' prognosis.
The clinical features, diagnosis, treatment, and prognosis of neuroinvasive listeriosis: a multinational study
(Springer, 2015) Arslan, F.; Meynet, E.; Sunbul, M.; Sipahi, O. R.; Kurtaran, B.; Kaya, S.; Inkaya, A. C.; Pagliano, P.; Sengoz, G.; Batirel, A.; Kayaaslan, B.; Yildiz, O.; Guven, T.; Turker, N.; Midi, I.; Parlak, E.; Tosun, S.; Erol, S.; Inan, A.; Oztoprak, N.; Balkan, I.; Aksoy, Y.; Ceylan, B.; Yilmaz, M.; Mert, A.
The aim of this study was to determine the independent risk factors, morbidity, and mortality of central nervous system (CNS) infections caused by Listeria monocytogenes. We retrospectively evaluated 100 episodes of neuroinvasive listeriosis in a multinational study in 21 tertiary care hospitals of Turkey, France, and Italy from 1990 to 2014. The mean age of the patients was 57 years (range, 19-92 years), and 64% were males. The all-cause immunosuppression rate was 54 % (54/100). Forty-nine (49 %) patients were referred to a hospital because of the classical triad of symptoms (fever, nuchal rigidity, and altered level of consciousness). Rhombencephalitis was detected radiologically in 9 (9 %) cases. Twenty-seven (64 %) of the patients who had cranial magnetic resonance imaging (MRI) performed had findings of meningeal and parenchymal involvement. The mean delay in the initiation of specific treatment was 6.8 +/- 7 days. Empiric treatment was appropriate in 52 (52 %) patients. The mortality rate was 25 %, while neurologic sequelae occurred in 13 % of the patients. In the multivariate analysis, delay in treatment [odds ratio (OR), 1.07 [95 % confidence interval (CI), 1.01-1.16]] and seizures (OR, 3.41 [95 % CI, 1.05-11.09]) were significantly associated with mortality. Independent risk factors for neurologic sequelae were delay in treatment (OR, 1.07 [95 % CI, 1.006-1.367]) and presence of bacteremia (OR, 45.2 [95 % CI, 2.73-748.1]). Delay in the initiation of treatment of neuroinvasive listeriosis was a poor risk factor for unfavorable outcomes. Bacteremia was one of the independent risk factors for morbidity, while the presence of seizures predicted worse prognosis. Moreover, the addition of aminoglycosides to ampicillin monotherapy did not improve patients' prognosis.
CLINICAL MANAGEMENT AND QUALITY OF LIFE IN PATIENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA UNDERGOING LIPID-APHERESIS IN TURKEY: FIRST RESULTS OF A NATION-WIDE SURVEY (A-HIT REGISTRY)
(Elsevier Ireland Ltd, 2016) Kayikcioglu, M.; Tokgozoglu, L.; Pirildar, S.; Yilmaz, M.; Kaynar, L.; Aktan, M.; Durmus, R.; Temizhan, A.; Ozcebe, O.; Akyol, T.; Okutan, H.; Sag, S.; Altunkeser, B.; Yenercag, M.; Kurtoglu, E.; Demircioglu, S.; Salcioglu, O.; Demir, M.; Yilmaz, H.
Clinoptilolite supported rutile TiO2 composites: Synthesis, characterization, and photocatalytic activity on the degradation of terephthalic acid
(Elsevier Science Bv, 2017) Yener, H. B.; Yilmaz, M.; Deliismail, O.; Ozkan, S. F.; Helvaci, S. S.
Clinoptilolite supported rutile TiO2 composites were synthesized for the enhancement of its photocatalytic performance in the degradation of the aqueous terephthalic acid solution under UVC illumination by the increase in its surface area and to simplify its recovery from the treated solution after use. The XRD spectra of the composites revealed the formation of pure rutile TiO2 on the surface of the clinoptilolite. The SEM images showed the formation of the spherical TiO2 clusters were composed of nano fibers on the surface of the clinoptilolite. For all composites synthesized, the dispersion of the TiO2 particles on the clinoptilolite led to a surface area larger than that of the bare TiO2 and clinoptilolite. The materials synthesized in the present study exhibited higher catalytic activity compared with the commercial Degussa P25 and anatase. Among the catalysts synthesized the TiO2/clinoptilolite with a weight ratio of 0.5 was found to be the most photoactive catalyst even though it contains a lesser amount of active TiO2. The kinetic of the reactions for different catalyst was found to be consistent with the pseudo first order kinetic model. The results of the Langmuir-Hinshelwood model showed the slight contribution of the adsorption on the degradation. The activity of the TiO2/clinoptilolite with a weight ratio of 0.5 decreased after repetitive use due to the accumulation of the TPA molecules on the surface of the catalyst. (C) 2016 Elsevier B.V. All rights reserved.
Comparison of Patients in Whom Double-J Stent Had Been Placed or Not Placed After Renal Transplantation in a Single Center: A Follow-up Study
(Elsevier Science Inc, 2015) Alci, E.; Ustun, M.; Sezer, T.; Yilmaz, M.; Ozdemir, M.; Unsal, M. G.; Uguz, A.; Sozbilen, M.; Toz, H.; Hoscoskun, C.
Background. Double-J (DJ) stents play an important role in modern urology to prevent undesirable side effects after surgery. We aimed to investigate the relationship of DJ stents with the demographic characteristics, surgical complications, urinary tract infection (UTI), and hematuria in the patients who underwent renal transplantation (Tx). Methods. Data of 354 patients who underwent renal Tx between 2008 and 2011 at Ege University were evaluated retrospectively; 331 patients were included in this study. The term DJ (-) represents patients in whom a DJ stent was not placed. "Primary DJ term" represents patients in whom the DJ stent was placed during the first Tx. "Secondary DJ term" represents the patients who had DJ after Tx for any complication. Results. Two hundred fifty-four (76.7%) patients were in the DJ (-) group, 52(15.7%) were in the primary DJ group, and 25(7.6%) were in the secondary DJ group. There were significant differences between the groups in terms of anastomosis type (P = .000), stay-in-hospital time (P = .000), surgical complication (P = .000), re-operation (P = .000), percutaneous nephrostomy (P = .000), UTI (P = .000), first-time UTI (P = .000), recurrent UTI (P = .000), positive hemoculture (P = .000), hematuria (P = .000), duration of dialysis before Tx (P = .000), live/deceased donor (P = .000), and delayed graft function (P = .009). Conclusions. Our choice is to use the DJ stent in selected high-risk patients and to keep the indications for DJ stent wider in deceased donor transplants by considering possible surgical complications. The use of the stent only in selected cases will decrease surgical complications due to stent placement.
Comparison of Patients in Whom Double-J Stent Had Been Placed or Not Placed After Renal Transplantation in a Single Center: A Follow-up Study
(Elsevier Science Inc, 2015) Alci, E.; Ustun, M.; Sezer, T.; Yilmaz, M.; Ozdemir, M.; Unsal, M. G.; Uguz, A.; Sozbilen, M.; Toz, H.; Hoscoskun, C.
Background. Double-J (DJ) stents play an important role in modern urology to prevent undesirable side effects after surgery. We aimed to investigate the relationship of DJ stents with the demographic characteristics, surgical complications, urinary tract infection (UTI), and hematuria in the patients who underwent renal transplantation (Tx). Methods. Data of 354 patients who underwent renal Tx between 2008 and 2011 at Ege University were evaluated retrospectively; 331 patients were included in this study. The term DJ (-) represents patients in whom a DJ stent was not placed. "Primary DJ term" represents patients in whom the DJ stent was placed during the first Tx. "Secondary DJ term" represents the patients who had DJ after Tx for any complication. Results. Two hundred fifty-four (76.7%) patients were in the DJ (-) group, 52(15.7%) were in the primary DJ group, and 25(7.6%) were in the secondary DJ group. There were significant differences between the groups in terms of anastomosis type (P = .000), stay-in-hospital time (P = .000), surgical complication (P = .000), re-operation (P = .000), percutaneous nephrostomy (P = .000), UTI (P = .000), first-time UTI (P = .000), recurrent UTI (P = .000), positive hemoculture (P = .000), hematuria (P = .000), duration of dialysis before Tx (P = .000), live/deceased donor (P = .000), and delayed graft function (P = .009). Conclusions. Our choice is to use the DJ stent in selected high-risk patients and to keep the indications for DJ stent wider in deceased donor transplants by considering possible surgical complications. The use of the stent only in selected cases will decrease surgical complications due to stent placement.
Comparison of Patients in Whom Double-J Stent Had Been Placed or Not Placed After Renal Transplantation in a Single Center: A Follow-up Study
(Elsevier Science Inc, 2015) Alci, E.; Ustun, M.; Sezer, T.; Yilmaz, M.; Ozdemir, M.; Unsal, M. G.; Uguz, A.; Sozbilen, M.; Toz, H.; Hoscoskun, C.
Background. Double-J (DJ) stents play an important role in modern urology to prevent undesirable side effects after surgery. We aimed to investigate the relationship of DJ stents with the demographic characteristics, surgical complications, urinary tract infection (UTI), and hematuria in the patients who underwent renal transplantation (Tx). Methods. Data of 354 patients who underwent renal Tx between 2008 and 2011 at Ege University were evaluated retrospectively; 331 patients were included in this study. The term DJ (-) represents patients in whom a DJ stent was not placed. "Primary DJ term" represents patients in whom the DJ stent was placed during the first Tx. "Secondary DJ term" represents the patients who had DJ after Tx for any complication. Results. Two hundred fifty-four (76.7%) patients were in the DJ (-) group, 52(15.7%) were in the primary DJ group, and 25(7.6%) were in the secondary DJ group. There were significant differences between the groups in terms of anastomosis type (P = .000), stay-in-hospital time (P = .000), surgical complication (P = .000), re-operation (P = .000), percutaneous nephrostomy (P = .000), UTI (P = .000), first-time UTI (P = .000), recurrent UTI (P = .000), positive hemoculture (P = .000), hematuria (P = .000), duration of dialysis before Tx (P = .000), live/deceased donor (P = .000), and delayed graft function (P = .009). Conclusions. Our choice is to use the DJ stent in selected high-risk patients and to keep the indications for DJ stent wider in deceased donor transplants by considering possible surgical complications. The use of the stent only in selected cases will decrease surgical complications due to stent placement.
Comparison of Preemptive Kidney Transplantation With Nonpreemptive Kidney Transplantation in a Single Center: A Follow-up Study
(Elsevier Science Inc, 2015) Unsal, M. G.; Yilmaz, M.; Sezer, T.; Celtik, A.; Unalp, O. V.; Uguz, A.; Alci, E.; Tamer, A. F.; Hoscoskun, C.; Toz, H.
Background and Aim. The effect of preemptive transplantation of kidneys from living donors on patient and allograft survival is controversial. In this study, we aimed to evaluate whether preemptive kidney transplantation performed without the development of patient dialysis-related complications has a favorable effect on patient and graft survival. Patients and Method. The study included 334 adult renal transplant recipients. Patients who underwent renal transplantation between January 2008 and December 2012 at a tertiary referral teaching hospital were followed, and outcomes were obtained by retrospective chart review. A total of 244 patients underwent dialysis before renal transplantation, whereas 90 patients underwent preemptive transplantation. Results. There were no significant differences between the 2 groups with regard to patients and graft survival rates (P > .05). Patient survival rates in preemptive and nonpreemptive groups were 98.9% and 96.3% in the first year, respectively (P = .199). Graft survival rates in preemptive and nonpreemptive groups were 96.7% and 93.0% in the first year, respectively (P = .163). Patient survival rates in preemptive and nonpreemptive groups were 98.9% and 95.7% in the third year, respectively (P = .155). Graft survival rates in preemptive and nonpreemptive groups were 93.5% and 88.5% in the third year, respectively (P = .138). There was a significant difference among years with regard to ratio of patients with preemptive transplantation (P = .009). The ratio was 17.5% in 2008, whereas it rose to 43.1% in 2012. Conclusion. Although preemptive kidney transplantation does not provide a significant patient and allograft survival advantage compared to nonpreemptive kidney transplantation, both therapeutic modalities provide good outcomes. Preemptive kidney transplantation has been an increasingly frequent renal replacement therapy option in recent years.
Comparison of Preemptive Kidney Transplantation With Nonpreemptive Kidney Transplantation in a Single Center: A Follow-up Study
(Elsevier Science Inc, 2015) Unsal, M. G.; Yilmaz, M.; Sezer, T.; Celtik, A.; Unalp, O. V.; Uguz, A.; Alci, E.; Tamer, A. F.; Hoscoskun, C.; Toz, H.
Background and Aim. The effect of preemptive transplantation of kidneys from living donors on patient and allograft survival is controversial. In this study, we aimed to evaluate whether preemptive kidney transplantation performed without the development of patient dialysis-related complications has a favorable effect on patient and graft survival. Patients and Method. The study included 334 adult renal transplant recipients. Patients who underwent renal transplantation between January 2008 and December 2012 at a tertiary referral teaching hospital were followed, and outcomes were obtained by retrospective chart review. A total of 244 patients underwent dialysis before renal transplantation, whereas 90 patients underwent preemptive transplantation. Results. There were no significant differences between the 2 groups with regard to patients and graft survival rates (P > .05). Patient survival rates in preemptive and nonpreemptive groups were 98.9% and 96.3% in the first year, respectively (P = .199). Graft survival rates in preemptive and nonpreemptive groups were 96.7% and 93.0% in the first year, respectively (P = .163). Patient survival rates in preemptive and nonpreemptive groups were 98.9% and 95.7% in the third year, respectively (P = .155). Graft survival rates in preemptive and nonpreemptive groups were 93.5% and 88.5% in the third year, respectively (P = .138). There was a significant difference among years with regard to ratio of patients with preemptive transplantation (P = .009). The ratio was 17.5% in 2008, whereas it rose to 43.1% in 2012. Conclusion. Although preemptive kidney transplantation does not provide a significant patient and allograft survival advantage compared to nonpreemptive kidney transplantation, both therapeutic modalities provide good outcomes. Preemptive kidney transplantation has been an increasingly frequent renal replacement therapy option in recent years.
Comparison of Preemptive Kidney Transplantation With Nonpreemptive Kidney Transplantation in a Single Center: A Follow-up Study
(Elsevier Science Inc, 2015) Unsal, M. G.; Yilmaz, M.; Sezer, T.; Celtik, A.; Unalp, O. V.; Uguz, A.; Alci, E.; Tamer, A. F.; Hoscoskun, C.; Toz, H.
Background and Aim. The effect of preemptive transplantation of kidneys from living donors on patient and allograft survival is controversial. In this study, we aimed to evaluate whether preemptive kidney transplantation performed without the development of patient dialysis-related complications has a favorable effect on patient and graft survival. Patients and Method. The study included 334 adult renal transplant recipients. Patients who underwent renal transplantation between January 2008 and December 2012 at a tertiary referral teaching hospital were followed, and outcomes were obtained by retrospective chart review. A total of 244 patients underwent dialysis before renal transplantation, whereas 90 patients underwent preemptive transplantation. Results. There were no significant differences between the 2 groups with regard to patients and graft survival rates (P > .05). Patient survival rates in preemptive and nonpreemptive groups were 98.9% and 96.3% in the first year, respectively (P = .199). Graft survival rates in preemptive and nonpreemptive groups were 96.7% and 93.0% in the first year, respectively (P = .163). Patient survival rates in preemptive and nonpreemptive groups were 98.9% and 95.7% in the third year, respectively (P = .155). Graft survival rates in preemptive and nonpreemptive groups were 93.5% and 88.5% in the third year, respectively (P = .138). There was a significant difference among years with regard to ratio of patients with preemptive transplantation (P = .009). The ratio was 17.5% in 2008, whereas it rose to 43.1% in 2012. Conclusion. Although preemptive kidney transplantation does not provide a significant patient and allograft survival advantage compared to nonpreemptive kidney transplantation, both therapeutic modalities provide good outcomes. Preemptive kidney transplantation has been an increasingly frequent renal replacement therapy option in recent years.
DOCK8 deficiency and diagnostic guidelines for hyper-IgE syndromes
(Wiley-Blackwell, 2012) Engelhardt, K.; Gertz, E.; Keles, S.; Schaeffer, A.; Ceja, R.; Sassi, A.; Graham, L.; Massaad, M.; Mellouli, F.; Benmustapha, I; Khemiri, M.; Kilic, S.; Etzioni, A.; Freeman, A.; Thiel, J.; Schulze, I; Al-Herz, W.; Metin, A.; Sanal, O.; Yeganeh, M.; Niehues, T.; Siepermann, K.; Weinspach, S.; Unal, E.; Patiroglu, T.; Dasouki, M.; Yilmaz, M.; Genel, F.; Aytekin, C.; Kutukculer, N.; Somer, A.; Kilic, M.; Reisli, I; Camcioglu, Y.; Gennery, A.; Cant, A.; Jones, A.; Gaspar, H.; Pietrogrande, M.; Baz, Z.; Al-Tamemi, S.; Lougaris, V; Lefranc, G.; Megarbane, A.; Boutros, J.; Galal, N.; Bejaoui, M.; Barbouche, M.; Geha, R.; Chatila, T.; Grimbacher, B.
The effects of tropicamide and cyclopentolate hydrochloride on laser flare meter measurements in uveitis patients: a comparative study
(Springer Science and Business Media B.V., 2020) Yilmaz, M.; Guven Yilmaz, S.; Palamar, M.; Ates, H.; Yagci, A.
Purpose: To investigate the effects of 1% cyclopentolate hydrochloride and 1% tropicamide eye drops on aqueous flare measurements by using the laser flare meter. Methods: One hundred forty eight eyes of 83 patients with inactive uveitis were enrolled. The patients were randomly assigned to receive either 1% tropicamide (Group 1) or 1% cyclopentolate hydrochloride (Group 2) as the mydriatic agent. Best corrected visual acuity (BCVA), intraocular pressure (IOP), aqueous flare reaction levels measured by laser flare meter device (FM 600, Kowa, Kowa Company Ltd, Nagoya, Japan) before and post dilatation agents were evaluated. Results: Group 1 consisted of 75 eyes and Group 2 consisted of 77 eyes. The mean age of Group 1 patients was 34.85 ± 12.60 (range, 12–64) years; the mean age of Group 2 was 36.92 ± 13.30 (range, 12–70) years (p > 0.05). The mean BCVAs of two groups were 0.16 ± 0.43 (range, 0.00–3.10) logMAR and 0.17 ± 0.42 (range, 0.00–3.10) logMAR, respectively. There were no statistically significant differences between Groups 1 and 2 regarding gender or clinical characteristics (p > 0.05). No significant differences were detected in pre- or post-dilatation values between two groups (p = 0.470, p = 0.998). Conclusions: As a result, anterior chamber flare values in uveitis patients do not differ significantly between 1% tropicamide and 1% cyclopentolate hydrochloride, and both agents can be safely used for dilatation during examination of patients with uveitis. © 2020, Springer Nature B.V.
Efficacy and Safety of ATG-Fresenius as an Induction Agent in Living-Donor Kidney Transplantation
(Elsevier Science Inc, 2017) Yilmaz, M.; Sezer, T. O.; Gunay, E.; Solak, I.; Celtik, A.; Hoscoskun, C.; Toz, H.
Background. Induction therapy is mostly recommended for deceased-donor transplantation, whereas it has some controversies in live-donor transplantation. In this study, we described the outcomes of live-donor renal transplant recipients who received ATG-Fresenius (ATG-F) induction. Methods. Live-donor transplantations in patients over 18 years old with ATG-F induction between 2009 and 2015 were included. All patients received quadruple immunosuppression, one of which was ATG-F induction. Biopsies after the artery anastomosis (zero hour) and protocol biopsies at the 6th month and at the 1st first year were obtained. Acute graft dysfunction was defined as a 20% to 25% increase in creatinine level from baseline. All acute rejection episodes were biopsy-confirmed. All episodes were initially treated with intravenous methyl prednisolone (MP) or ATG-F if resistant to MP. Four hundred twenty-two patients with live-donor transplantation were evaluated. The mean age was 40 +/- 13 (18-73) years. The mean panel-reactive antibody levels were 42% +/- 30% and 45% +/- 30% for class I and II, respectively. Results. The mean mismatch number for living unrelated donors (n = 112) was 4.6 +/- 1.0. Acute rejection rate was 29.1% (123 patients) within the first year. The mean cumulative ATG-F doses for per patient and per kilogram were 344 +/- 217 mg and 5.1 +/- 2.7 mg, respectively. Patient survival rates were 98.3% and 96.7% for 12 months and 60 months, respectively. Death-censored graft survival rates were 97.6% and 92.1% for 12 months and 60 months, respectively. Conclusions. ATG-F induction provided excellent graft and patient survival rates without any significantly increased side effects. Increasing sensitized patient numbers, more unrelated donors, increasing re-transplantation numbers, and more desensitization protocols make ATG-F more favorable in an induction regimen.
Evaluation of Cases of Graft Nephrectomy After Graft Loss in Patients With Renal Transplantation
(Elsevier Science Inc, 2018) Ustun, M.; Alci, E.; Budak, S.; Demir, H. B.; Yucel, C.; Sen, S.; Yilmaz, M.; Toz, H.
Introduction. Renal transplantation is undoubtedly considered the best renal replacement therapy. Graft nephrectomy can be performed in patients with renal transplantation because of complications associated with the failed graft. We aimed to retrospectively investigate the characteristics of patients who underwent graft nephrectomy. Materials and Methods. Between January 2000 and November 2013, the records of 757 patients who had renal transplantation in Ege University Faculty of Medicine Hospital Nephrology-Transplantation outpatient clinic were examined. Sixty-four patients who underwent graft nephrectomy were included in the study. Patients were divided into 2 groups according to the timing of graft nephrectomy. The group of 30 patients who underwent graft nephrectomy in the first 56 days after the renal transplantation was referred to as the "early group" and the group of 34 patients who underwent graft nephrectomy after 56 days was referred to as "late group." Results. In our study, we found the body mass index to be significantly higher in those with early graft loss (P = .02). We found that there was a difference between the groups in terms of sex (P = .012). When the mortality and morbidity rates after graft nephrectomy were examined, mortality was observed in 3 of the 64 patients in the study and morbidity in 1 patient. Conclusion. According to our study, the body mass indices and ages of the subjects who need early graft nephrectomy are higher. However, male sex was significantly more prevalent in patients who underwent graft nephrectomy in the late period compared with the early period.
Extrasolar planet searches at the TUG: Test observations and capabilities
(Elsevier Science Bv, 2013) Yilmaz, M.; Selam, S. O.; Sato, B.; Izumiura, H.; Bikmaev, I.; Ando, H.; Kambe, E.; Keskin, V.
A small group of collaborators was established at the end of 2007 with the objective of starting an extra-solar planet search at the TUBITAK National Observatory of Turkey. High resolution spectra of some radial velocity standards and planet-harbouring stars have since been obtained using an iodine (I-2) absorption cell placed in front of the entrance slit of the Coude Echelle Spectrograph (CES) in the 1.5-m Russian-Turkish Telescope (RTT150). To determine precise radial velocity measurements for these stars, a new computer code was developed by one of the collaborators (MY) using an IDL (Interactive Data Language) programing platform specific to the RTT150's CES + I-2-cell data. This paper summarises the technical setup, the new code, the test observation results and the precision achieved in the radial velocity measurements. The results from radial velocity standards and planet-harbouring stars show that a precision of approximately 10 m s(-1) was achieved with the CES on the RTT150 during the three years of test observations. In addition, the instrumental profile (IP) characteristics of the CES on the RTT150 in this study were derived by modelling the observed B-star + I-2 spectra. The observed instrumental profiles were a typical Gaussian shape and exhibited small variations that depended on the position on the CCD and also varied between exposures, which affected the precision of the radial velocity measurements. (C) 2012 Elsevier B.V. All rights reserved.
Factor VIII-intron 1 inversion of Hemophilia A patients in West Anatolia
(Macedonian Acad Sciences Arts, 2007) Pehlivan, M.; Pehlivan, S.; Buyukkececi, F.; Cagirgan, S.; Yilmaz, M.; Omay, Bedii S.; Tombuloglu, M.; Kavakli, K.
Hemophilia A (HA) is a hereditary, life-threatening and disabling disorder. In this study, we have examined 61 unrelated HA patients in order to identify the incidence of the intron 1 factor VIII (FVIII) gene inversion in the West Anatolian population. According to the results of DNA analyses of the 61 HA patients, no intron 1 inversion of the FVIII gene was found.

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