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Öğe Intensive Lipid Reduction and Proinflammatory Markers in the MODEST Study [Modest çaliflmas&203a;nda yog¨un lipid düflürücü tedavi ve proinflematuvar belirteçler](Turkiye Klinikleri, 2010) Kanat M.; Yildiz O.; Tunçkale A.; Ceyhan B.O.; Karagöz Y.; Altuntafl Y.; Og¨uz A.Objective: Statin therapy is well known to reduce inflammatory markers such as tumor necrosis factor-?(TNF- ?), interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP). However, whether this relationship is maintained in the setting of targeting very low levels of LDL (<70 mg dl) in patients with type 2 diabetes has not been clearly established. Materials and Methods: We measured hsCRP, IL-6, and TNF- ? in 43 subject enrolled into the multicenter, open-label, crossover prospective study evaluating the effects of lipid-lowering treatment on steroid synthesis in patients with type 2 diabetes (MODEST study). Subjects with diabetes and coronary artery disease were treated with 80 mg of atorvastatin for 12 weeks. The effect of treatment on pro-inflammatory markers was assessed after 12 weeks. Results: High-dose atorvastatin treatment significantly reduced the plasma levels of IL-6 and hsCRP (p<0.05, p<0.001, respectively), but not of TNF- ? (p=0.051). Conclusion: Atorvastatin treatment targeting very low LDL-cholesterol level reduced the levels of several important inflammatory markers in patients with type 2 diabetes and coronary heart disease.Öğe IoT Applications and Protocols: An Air Quality Monitoring Example(Institute of Electrical and Electronics Engineers Inc., 2020) Sokullu R.; Balci A.; Yildiz O.One of the dominating technologies coming along with the upheaval of wireless communications in the 5G era is the Internet of Things (IoT). Promising to make even the smallest devices like sensors and actuators 'smart' and allow them to connect over the network, this technology is associated with a vast number of diverse applications: from smart home, to smart city and smart farming applications, to industrial and healthcare applications. Such an abundance of applications and variety of characteristics poses a serious problem from communication point of view since communication networks so far have been designed and engineered to connect human-to-human (H2H). Large amounts of data are transferred with min delay between well-defined end users. The new paradigm of M2M communications envisages connecting many billions of anonymous devices, for probably only a few kbps or keep devices connected for very long periods of time in unattended, unreachable areas where they have to survive on their limited power supply. Existing communication protocols and architectures are mostly unsuitable for this new type of communications. So, in the last decade we have seen a lot of research and standardization work in designing network protocols that will suit the needs of IoT. In this paper we discuss the characteristics of M2M communications, the protocols suitable to IoT systems and present an example application for air quality monitoring realized in Turkey. © 2020 IEEE.Öğe An overview of agricultural extension services in Turkey(National Centre for Agrarian Sciences, 2016) Boyaci M.; Yildiz O.In the study, public extension service is examined through data collected from 538 extension workers in nine agricultural provinces of Turkey. Turkish extension service is influenced by the general top down and training-visit approaches which were employed in the past. These approaches are mainly directed to conventional production and yield increase, by using a topdown process that gives little place for human resources development and sustainable agriculture. New opportunities of digital devices such as cell phones, internet, and e-mail are generally underutilized in farmer training. The local participation is not at intended level during the formulation of extension activities in Turkey. © 2016, National Centre for Agrarian Sciences. All rights reserved.Öğe The prevalence and epidemiological characteristics of hepatitis B virus and hepatitis C virus coinfection in Turkey [Türkiye'de hepatit B virüs ve hepatit C virus koenfeksiyonu prevalansi{dotless} ve epidemiyolojik özellikleri](Turkiye Klinikleri, 2013) Aygen B.; Çelen M.K.; Köksal I.; Tosun S.; Karabay O.; Yamazhan T.; Yildiz O.; Ayaz C.; Tabak F.We aimed to determine prevalence and epidemiological characteristics of cases coinfected with hepatitis B virus (HBV)/hepatitis C virus (HCV) in Turkey. Material and Methods: The data for this study was obtained from Turk-Hepatitis Registry (HEP-NET) Project, which includes real-life cohort of hepatitis patients from 15 centers in Turkey, and is supported by Viral Hepatitis Society. In the project, 10,165 hepatitis cases were evaluated in 10 hospitals. Results: According to initial visit results, HBV/HCV coinfection was detected in 99 patients. The ratio was 974/100 000. The mean age of the cases was 40.9+21.7 years, 56.6% of them were males and 43.4% were females,. The major risk factors were dental therapy, any surgical procedure, hemodialysis and blood transfusion. The mean alanine aminotransferase (ALT) levels were 70.9±49.1 IU/L in coinfected patients. In 12% of cases HBeAg was positive. The median HCV RNA level was found 0 IU/mL (minimum: 50-maximum: 2.18x107 IU/mL), and the median HBV DNA level was found 2.50x102 IU/mL (minimum: 12-maximum: 1.70x108 IU/mL). In 8.1% of the patients both HCV RNA and HBV DNA were positive, and in 87.5% of cases HCV infection was dominant. The most important risk factor was hemodialysis (25%) in this group. Conclusion: This is the most detailed study which evaluates the prevalence of HBV/HCV coinfection in Turkey. HBV/HCV coinfection prevalence was not higher than HBV or HCV monoinfections. In cases where both HCV RNA and HBV DNA were positive, HCV was predominant. © 2013 by Türkiye Klinikleri.Öğe Vitamin D status of exclusively breastfed 4-month-old infants supplemented during different seasons(American Academy of Pediatrics, 2012) Halicioglu O.; Sutcuoglu S.; Koc F.; Yildiz O.; Akman S.A.; Aksit S.OBJECTIVE: To examine the vitamin D status of 4-month-old exclusively breastfed infants supplemented with 400 IU daily of vitamin D and to determine whether there was any seasonal variation in serum 25-hydroxyvitamin D (25(OH)D) levels of infants. METHODS: In this cross-sectional study, serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25(OH)D levels of 143 exclusively breastfed 4-month-old infants supplemented daily with 400 IU of vitamin D were measured in a temperate latitude, Izmir, Turkey, between May 2008 and April 2009. A questionnaire on demographic characteristics of infants and mothers, vitamin D supplementation of infants after birth, mothers' multivitamin supplementation, dressing habits, and consumption of dairy products during pregnancy was used. RESULTS: Vitamin D deficiency (?50 nmol/L) and insufficiency (51-74 nmol/L) were determined in 40 (28%) and 55 (38.5%) infants, respectively. During winter days, serum 25(OH)D levels were <20 ng/mL in 45.4% of infants and <10 ng/mL in 10.6% of infants. Season of blood sampling, compliance of vitamin D supplementation, maternal education level, and consumption of dairy products were highly predictive of serum 25(OH)D levels in multiple linear regression analysis (P < .05). The use of the Pearson correlation test found a statistically significant negative correlation between 25(OH)D and parathyroid hormone levels (r = -0.419, P < .001). CONCLUSIONS: Despite supplementation with 400 IU of vitamin D daily, the rate of vitamin D deficiency was worryingly high in 4-month-old exclusively breastfed infants living in Izmir, Turkey. So, additional studies are needed to clarify optimal amount of vitamin D supplementation to the infants, especially during winter days. Copyright © 2012 by the American Academy of Pediatrics.
