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Öğe Angiodysplasia in a duodenal diverticulum as an unusual cause of upper gastrointestinal bleeding(Lippincott Williams & Wilkins, 2001) Gunsar, F; Yildiz, C; Aydin, A; Ozutemiz, OAThe majority of duodenal diverticula are asymptomatic but may also induce major haemorrhage on rare occasions. Gastrointestinal bleeding due to angiodysplasia in a duodenal diverticulum is very rare, We present a 70-year-old woman with repeated melaena in whom the diagnosis of angiodysplasia in a diverticulum of the fourth part of the duodenum could be made by standard upper endoscopy, Eur J Gastroenterol Hepatol 13:717-719 (C) 2001 Lippincott Williams & Wilkins.Öğe Autoantibodies in patients with nonalcoholic steatohepatitis of unknown etiology(W B Saunders Co-Elsevier Inc, 1999) Akarca, US; Ersoz, G; Gunsar, F; Yilmaz, M; Yildiz, C; Karasu, Z; Batur, YÖğe The effect of trimetazidine on intrahepatic cholestasis caused by carmustine in rats(Wiley, 2001) Demir, A; Ozutemiz, O; Yildiz, C; Yuce, G; Tekesin, O; Ilter, TThis study investigated the effect of trimetazidine (TMZ), known as an anti-oxidant agent, on intrahepatic cholestasis caused by Carmustine (BCNU) in rats. Rats were assigned into four groups. The first group (Saline) consisted of 12 rats, which were injected with 2 ml/kg of saline intraperitoneally (IP) 48 h before the study. The second group (corn oil group, n = 15), which were injected with 2 ml/kg of corn oil IP 48 h before the study. The third group (BCNU group, n = 16), which were injected with 2 ml/kg of corn oil + 25 mg/kg BCNU IP 48 h before the study. The fourth group (TMZ group, n = 12), which were injected with 2.5 mg/kg per day of TMZ IF, administered at the same hour of the day as a single-dose. Twelve hour after the first dose of TMZ, corn oil 2 ml/kg + BCNU 25 mg/kg IP were injected, and the rats were included in the study 48 h after the administration of corn oil + BCNU. Following a pentobarbital anaesthesia, abdomen was opened with incision, a cannula was placed into the channel of choledocus, and the amount of bile was measured per hour. Then intracardiac blood sample was taken, and consequently centrifuged to obtain the plasma. Finally, the rats were killed with cervical dislocation, and their livers were removed and weighted. In addition to histopathological examination of liver, the levels of malon dialdehyde (MDA), oxidised glutation (GSSG), and reduced glutation (GSH) were detected. Also the osmolality of bile and plasma was estimated in mOsm/kg. As a result, the biliary flow was seen to decrease in BCNU group (P < 0.005), but to be normal in TMZ group. The serum level of conjugated biluribin was higher in BCNU group compared to other groups (P < 0.05 for each). Although the level of total glutation was lower (P < 0.005) in TMZ group, GSH/GSSG ratio was normal. These findings suggest that TMZ has a protective effect on intrahepatic cholestasis caused by BCNU. <(c)> 2001 Elsevier Science Ireland Ltd. All rights reserved.Öğe The effect of trimetazidine on intrahepatic cholestasis induced by carmustine in rats(W B Saunders Co-Elsevier Inc, 1999) Demir, AO; Ozutemiz, O; Tanyalcin, T; Huseyinov, A; Yuce, G; Karaoglu, AO; Yildiz, C; Tekesin, O; Ilter, T; Batur, YÖğe Effects of trimetazidine on acetic acid-induced colitis in female Swiss rats(Taylor & Francis Inc, 2003) Kuralay, F; Yildiz, C; Ozutemiz, O; Islekel, H; Caliskan, S; Bingol, B; Ozkal, SInduction of colitis by acetic acid (AA) in the rat is widely used experimental model of inflammatory bowel disease (IBD) and ulcerations. AA as an irritant induces colitis involving infiltration of colonic mucosa with neutrophils and increased production of inflammatory mediators, such as hydrogen peroxide (H2O2), nitric oxide (NO), myeloperoxiclase activity (MPO), and tumor necrosis factor (TNF-alpha). Trimetazidine (TMZ), an antianginal compound, was administered to investigate if its cytoprotective features in cardiac tissue are also effective in AA colitis where ischemic injury contributes to colitis. Administration of TMZ intraperitoneally improved the macroscopic and microscopic score alterations produced by AA, AA administration significantly elevated colonic MPO activity; however, treatment with TMZ significantly lowered this enzyme activity compared to AA. AA administration significantly enhanced superoxide dismutase (SOD) activities, except for A/A + TMZ given rectally, TMZ treatment significantly, lowered nitrate levels, but AA increased these levels. AA administration markedly lowered TNF-alpha levels, but TMZ treatment elevated these levels to control. These findings indicate that overproduction of NO may be involved in the immunosuppression observed during acute AA-induced rat colitis, In conclusion, TMZ treatment was more effective via the intraperitoneal than rectal route, and may be beneficial in therapy of colitis.Öğe Effects of trimetazidine on acetic acid-induced colitis in female Swiss rats(Taylor & Francis Inc, 2003) Kuralay, F; Yildiz, C; Ozutemiz, O; Islekel, H; Caliskan, S; Bingol, B; Ozkal, SInduction of colitis by acetic acid (AA) in the rat is widely used experimental model of inflammatory bowel disease (IBD) and ulcerations. AA as an irritant induces colitis involving infiltration of colonic mucosa with neutrophils and increased production of inflammatory mediators, such as hydrogen peroxide (H2O2), nitric oxide (NO), myeloperoxiclase activity (MPO), and tumor necrosis factor (TNF-alpha). Trimetazidine (TMZ), an antianginal compound, was administered to investigate if its cytoprotective features in cardiac tissue are also effective in AA colitis where ischemic injury contributes to colitis. Administration of TMZ intraperitoneally improved the macroscopic and microscopic score alterations produced by AA, AA administration significantly elevated colonic MPO activity; however, treatment with TMZ significantly lowered this enzyme activity compared to AA. AA administration significantly enhanced superoxide dismutase (SOD) activities, except for A/A + TMZ given rectally, TMZ treatment significantly, lowered nitrate levels, but AA increased these levels. AA administration markedly lowered TNF-alpha levels, but TMZ treatment elevated these levels to control. These findings indicate that overproduction of NO may be involved in the immunosuppression observed during acute AA-induced rat colitis, In conclusion, TMZ treatment was more effective via the intraperitoneal than rectal route, and may be beneficial in therapy of colitis.Öğe Severe toxic hepatitis associated with amoxycillin and clavulanic acid(Blackwell Science Ltd, 2001) Ersoz, G; Karasu, Z; Yildiz, C; Akarca, US; Yuce, G; Batur, YToxic hepatitis secondary to amoxycillin-clavulanic acid is an infrequent clinical picture. Most of the cases are reported to have a benign course. We report two cases of severe hepatic failure following amoxycillin-clavulanic acid use. One of the cases had cholestatic features primarily, and the other had hepatocellular injury prominently. The first case had also findings of trombotic trombositic purpura and had a fatal course.
