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    Comparison of psoriasis area and severity index and physician's global assessment in determining psoriasis severity
    (Kuwait Medical Assoc, 2021) Acar, Ayda; Bozkurt, Ada; Yenipazar, Gizem Kocabas; Alper, Sibel; Ceylan, Can
    Objective: In clinical studies, it is crucial to assess psoriasis severity accurately and with no substantial variation between different raters. The Psoriasis Area and Severity Index (PASI) and Physician Global Assessment (PGA) are the two most commonly used tools for the assessment of psoriasis severity. The aim of this study was to evaluate the intra-rater and inter-rater reliability of these methods and to determine whether inter-rater reliability is affected by rater experience. Design: An open uncontrolled study Setting: Dermatology Department of Ege University, Medical Faculty Subjects: Fifty-five patients with plaque psoriasis who were examined between 15 August 2012 and 15 November 2012 in the dermatology department of Ege University Interventions: Three dermatology residents with varying experience evaluated the patients individually using both the PASI and PGA for each patient (in that order). Main Outcome Measure: PASI and PGA Results: PASI and PGA scores showed high intra-rater correlation for all three residents. Inter-rater reliability for PASI was high between the most experienced and second most experienced resident and between the most experienced and least experienced resident. However, inter-rater reliability for PGA was high between the most experienced and second most experienced residents, but only moderate between the most experienced and least experienced resident. Conclusions: There were no significant interrater differences between PGA and PASI scores in our study. However, because PGA is more subjective and may be affected by rater experience, PASI is considered to be a more reliable method for assessing severity of psoriasis.
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    Serum Amyloid A and Lipoprotein Associated Phospholipase A(2) Levels in Patients with Malign Melanoma: Correlations with Clinical Assessment and Stage
    (Galenos Yayincilik, 2018) Kayas, Yavuz; Sagin, Ferhan; Akcay, Yasemin; Yenipazar, Gizem Kocabas; Azarsiz, Elif; Sozmen, Eser; Ozdemir, Fezal; Karaarslan, Isil
    Objective: The lack of validated, sensitive, and specific biomarkers for early diagnosis and follow-up of patients with malign melanoma (MM) is a major problem today. In this study, we aimed to investigate the correlations of two inflammatory biomarkers-serum amyloid A (SAA) and lipoprotein associated phospholipase A 2 (Lp-PLA(2))-in clinical follow-up and staging of MM. Methods: Lactate dehydrogenase (LDH) and C-reactive protein (CRP) (Routine), SAA and S100B (ELISA), and Lp-PLA(2) (PLAC (R) Test) activity levels were examined in histologically and clinically confirmed MM patients (n=131) and in healthy controls (n=27). Results: Sedimentation rate and LDH, CRP, S100B, SAA, Lp-PLA(2) activities were found to be significantly higher in MM patients compared to control group (p<0.05). SAA showed the strongest correlation with disease stage (Spearman's correlation coefficient=0.622, p=0.000). Receiver operating characteristic analysis revealed that SAA exhibited the largest area under the curve=0.984, p=0.000, highest sensitivity (95%) and specificity (93%). Pearson's test indicated a weak positive correlation between SAA levels and Lp-PLA(2) activity (r=0.311, p=0.000). Conclusion: This is the first study to evaluate the activity of inflammatory biomarker Lp-PLA(2) in melanoma patients. Both SAA and Lp-PLA(2) were in highest levels in stage 4 patients, and they are thought to be candidate biomarkers to be used in detecting tumor progression. According to our results, SAA is the biomarker which correlates best with disease stage in MM.
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    Toxic epidermal necrolysis associated with radiotherapy and phenytoin in a patient with non-Hodking's lymphoma: A case report
    (Elsevier Science Bv, 2016) Keklik, Fatma; Ozkan, Melda Comert; Yenipazar, Gizem Kocabas; Yaman, Banu; Saydam, Güray; Sahin, Fahri
    Toxic epidermal necrolysis (TEN) is a disease which is characterized by fever and desquamation of the skin and mucosal membranes. It is usually related with drugs, especially aromatic anticonvulsants which are recognized as the most common cause of this disorder. Cranial irradiation may act as a precipitating factor along with anticonvulsants for the development of TEN. We report a 28-year-old patient with central nervous system (CNS) relapsed non Hodgkin lymphoma (NHL) who developed TEN after cranial radiotherapy and concurrent phenytoin treatment. (C) 2015 Published by Elsevier Sp. z o.o. on behalf of Greater Poland Cancer Centre.