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Öğe Can polyglactin mesh be used for prevention of seroma after mastectomy: an experimental study(Springer Wien, 2014) Yeniay, L.; Unalp, O. V.; Uguz, A.; Unver, M.; Karaca, A. C.; Sezer, T. O.; Yoldas, T.; Demir, H. B.; Zekioglu, O.; Kapkac, M.; Yilmaz, R.Background Seroma formation is still a common problem in breast surgery. Seroma formation is associated with morbidity and financial loss. Fibrin glue was used in several studies for solution, but the results were controversial. On the other hand surgical meshes are promising to prevent the seroma formation. Methods A total of 48 female Sprague-Dawley rats were randomly assigned to four groups. Each underwent radical mastectomy, axillary lymph node dissection, and disruption of the dermal lymphatic vessels. Group 1 is the control group (n = 12). In group 2 (n = 12), 1 x 1 cm polyglactin 910 mesh (Vicryl, Ethicon Johnson&Johson USA) is placed over the chest wall under the skin flaps prior to closure. The animals in group 3 received 0.5 mL fibrin glue (Baxter Healthcare Ltd. United Kingdom) topically throughout the wound before the closure (n = 12). The animals in group 4 (n = 12) received 0.5 mL fibrin glue topically throughout the wound, and 1 x 1 cm polyglactin 910 mesh is placed under the skin flaps prior to the closure. Full thickness tissue samples from both the chest wall and the skin were harvested. The harvested tissue samples were evaluated by a single pathologist in a blind fashion. Results The mean seroma volume of the control group was 1.536 mL whereas the mean seroma volume of the groups 2, 3, and 4 were 1.189, 0.438, and 0.556 respectively. Mean seroma volume was significantly lower, adhesion index and foreign body reaction were higher in group 4. Conclusion Although various studies show controversial results to prevent the seroma formation. This experimental study is an evidence that fibrin glue and polyglican mesh reduce seroma with increasing inflammatory reaction.Öğe Effect of previous excisional biopsy on sentinel lymph node biopsy(Springer, 2007) Yararbas, U.; Argon, A. M.; Yeniay, L.; Yazici, B.; Duygulu, S.; Sen, C.; Kapkac, M.Öğe Expression of cyclin D1 and its relation with ER, PgR, C-erbB2, Ki-67, and p53 in breast cancer.(Amer Soc Clinical Oncology, 2010) Haydaroglu, A.; Demirci, S.; Demir, D.; Aydin, B.; Bolukbasi, Y.; Zekioglu, O.; Yeniay, L.; Ozdemir, N.; Gokmen, E.; Ylmaz, R.Öğe FACTORS CD10, CYTOKERATIN 19 AND STAGING-GRADING SYSTEMS IN PREDICTING THE PROGNOSIS OF PANCREATIC NEUROENDOCRINE TUMORS (PNET)(Editura Acad Romane, 2012) Uguz, A.; Unalp, O. V.; Yeniay, L.; Farajov, R.; Yoldas, T.; Sezer, T. O.; Ipek, N. Y.; Nart, D.; Yilmaz, F.; Sozbilen, M.; Coker, A.Objective. This study was undertaken to examine prognostic factors in patients with pancreatic neuroendocrine tumors (PNET) undergoing surgical treatment to evaluate the prognostic value of recently introduced immunohistochemical staining methods of CD10 and cytokeratin 19. Materials and Methods. Tumors were classified on the basis of 2004 WHO Classification Guidelines and European Neuroendocrine Tumor Society (ENETS) grading system. Immunohistochemical staining with Ki-67, CD10 and cytokeratin 19 was performed. Results. A total of 36 patients with a mean age of 53.7 +/- 12.0 years were included. Overall, 33 patients had a long-term follow-up with 10 patients (30.3%) experiencing recurrence. Seven patients (21.1%) died. Clinical parameters that were associated with recurrence included liver metastasis at the time of surgery and extra-pancreatic invasion (p < 0.005). Positive surgical margins, extra-pancreatic invasion, and multi-focal disease were associated with reduced survival (p < 0.05). In addition, there was an association between survival and WHO 2004 classification (p < 0.05). Conclusions. Although vascular and peripancreatic invasion showed increased risk of recurrence, they were unrelated to survival. Of the histopathological examinations, Ki-67 and mitotic activity showed a correlation with both recurrence and survival, while immunohistochemical staining with cytokeratin 19 and CD 10 did not provide adequate prognostic information.Öğe Invasive carcinoma and ductal carcinoma coexisting with Paget disease of the nipple(Springer, 2013) Buberal, G. Emiroglu; Acar, K.; Yeniay, L.; Kapkac, M.; Yilmaz, R.; Zekioglu, O.; Ozdemir, N.Öğe Is the Memorial Sloan-Kettering Cancer Center breast cancer nomogram feasible on Turkish breast cancer patients? Analysis of 740 patients(Amer Soc Clinical Oncology, 2011) Yeniay, L.; Carti, E. B.; Karaca, C. A.; Yararbas, U.; Zekioglu, O.; Kapkac, M.Öğe Prediction of malignancy upgrade rate in high-risk breast lesions using an artificial intelligence model: a retrospective study(Galenos Publishing House, 2023) Aslan, Ö.; Oktay, A.; Katuk, B.; Erdur, R.C.; Dikenelli, O.; Yeniay, L.; Zekioğlu, O.PURPOSE High-risk breast lesions (HRLs) are associated with future risk of breast cancer. Considering the pathological subtypes, malignancy upgrade rate differs according to each subtype and depends on various factors such as clinical and radiological features and biopsy method. Using artificial intelligence and machine learning models in breast imaging, evaluations can be made in terms of risk estimation in different research areas. This study aimed to develop a machine learning model to distinguish HRL cases requiring surgical excision from lesions with a low risk of accompanying malignancy. METHODS A total of 94 patients who were diagnosed with HRL by image-guided biopsy between January 2008 and March 2020 were included in the study. A structured database was created with clinical and radiological characteristics and histopathological results. A machine learning prediction model was created to make binary classifications of lesions as malignant or benign. Random forest, decision tree, K-nearest neighbors, logistic regression, support vector machine (SVM), and multilayer perceptron machine learning algorithms were used. Among these algorithms, SVM was the most successful. The estimations of malignancy for each case detected by artificial intelligence were combined and statistical analyses were performed. RESULTS Considering all cases, the malignancy upgrade rate was 24.5%. A significant association was ob-served between malignancy upgrade rate and lesion size (P = 0.004), presence of mammography findings (P = 0.022), and breast imaging-reporting and data system category (P = 0.001). A statistically significant association was also found between the artificial intelligence prediction model and malignancy upgrade rate (P < 0.001). With the SVM model, an 84% accuracy and 0.786 area-under-the-curve score were obtained in classifying the data as benign or malignant. CONCLUSION Our artificial intelligence model (SVM) can predict HRLs that can be followed up with a lower risk of accompanying malignancy. Unnecessary surgeries can be reduced, or second line vacuum exci-sions can be performed in HRLs, which are mostly benign, by evaluating on a case-by-case basis, in line with radiology–pathology compatibility and by using an artificial intelligence model. © 2023, Turkish Society of Radiology. All rights reserved.Öğe Prognostic factors affecting ipsilateral tumor recurrence and distant metastasis after breast-conserving surgery(Elsevier Sci Ltd, 2016) Aktas, A.; Yeniay, L.; Kapkac, M.; Yilmaz, R.Öğe Toxoplasma gondii destroys Her2/Neu-expressing mammary cancer cells in vitro using a continuous feed medium approach(NLM (Medline), 2020) Atalay Şahar, E.; Döşkaya, M.; Karakavuk, M.; Can, H.; Gül, A.; Gürüz, A.Y.; Yeniay, L.INTRODUCTION: Toxoplasma gondii is an opportunistic protozoan and can be grown using several human cell lines. Breast cancer is the second leading cause of cancer death in women. Her2/Neu-expressing mammary cancer cell lines called TUBO can be grown in vitro. In recent years, protozoan parasites have become popular means of use in cancer therapy research. In this study, we analyzed whether T. gondii tachyzoites can destroy TUBO cells using a novel continuous feed medium approach. METHODOLOGY: Two sets of flasks (each containing four groups) containing TUBO cells were inoculated with T. gondii Ankara strain tachyzoites. First set containing 5×106 TUBO cells were inoculated with TUBO-tachyzoite ratios of 1:2, 1:1, 2:1, and 4:1 and second set containing 1×106 TUBO cells were inoculated with TUBO-tachyzoite ratios of 10:1, 100:1, 1000:1, and 2000:1. Thereafter, culture supernatants were harvested at various days until TUBO cells were destroyed and tachyzoites were counted. RESULTS: In the first and second sets of flasks, TUBO cells were destroyed between days 8 to 12 and 12 to 25, respectively. In addition, the amount of tachyzoites increased 7- 43 and 595 to 112500 times in the first and second set of flasks, respectively. CONCLUSIONS: These results show that T. gondii tachyzoites successfully destroy Her2/Neu-expressing mammary cancer cells using a continuous feed medium approach. Although this idea may be too premature for the moment, the approach defined herein may support future researchers investigating the relationship between cancer and parasites which can make important progress toward saving cancer patient lives. Copyright (c) 2020 Esra Atalay Sahar, Mert Doskaya, Muhammet Karakavuk, Huseyin Can, Aytul Gul, Adnan Yuksel Guruz, Aysu Degirmenci Doskaya, Levent Yeniay.Öğe Tumour forming efficiencies of TUBO cell line expressing Her2 in two different mice strains with Matrigel matrix to develop animal models for novel immunotherapies(Elsevier Sci Ltd, 2016) Anil, M.; Iz, S. Gulce; Metiner, P. Saglam; Sahar, E. Atalay; Can, H.; Zekioglu, O.; Doskaya, M.; Yeniay, L.Öğe Ultrafast circulating breast tumor DNA detection in blood by CRISPR/dCas9 biosensor(Wiley, 2021) Uygun, Z. O.; Yeniay, L.; Sagin, F.[No Abstract Available]Öğe Validation of Three Different Nomograms to Predict the Risk of Non-Sentinel Lymph Node Involvement in Turkish Breast Cancer Patients with Sentinel Lymph Node Metastasis(Elsevier Sci Ltd, 2012) Yeniay, L.; Karaca, A. C.; Carti, E.; Ozdemir, N.; Yararbas, U.; Zekioglu, O.; Yilmaz, R.; Kapkac, M.
