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Öğe Abnormal cervical cytology and allogeneic stem cell transplantation(Nature Publishing Group, 2017) Soyer, N.; Akdemir, A.; Serin, G.; Ulukus, M.; Saydam, G.; Vural, F.Öğe Adenomyosis: prevalence, risk factors, symptoms and clinical finding's(I R O G Canada, Inc, 2007) Yeniel, O.; Cirpan, T.; Ulukus, M.; Ozbal, A.; Gundem, G.; Onener, S.; Zekioglu, O.; Yilmaz, H.Objective: This prospective study investigated the prevalence of adenomyosis in histopathological examinations of patients who had undergone hysterectomy due to various indications in our clinic. Epidemiological characteristics, predisposing risk factors, symptoms and clinical findings of adenomyosis were evaluated. Method: A total of 298 subjects who had undergone abdominal, vaginal or laparoscopic hysterectomy with/without salpingo-oophorectomy between October 2003 and April 2004 in our clinic were included. Uterine specimens obtained through hysterectomy were weighed and histopathologically examined in the Pathology Department of Ege University. The study group (n = 103), cases with adenomyosis, was compared with the control group (n = 195), cases without adenomyosis, with respect to the epidemiological, clinical and histopathological characteristics. Results: The prevalence of adenomyosis in 298 subjects was 36.2% (103). Duration of the reproductive period in patients with adenomyosis was found to be significantly longer than for those in the control group (p < 0.05). Prevalence of pelvic pain, dysmenorrhea and dyspareunia was also significantly higher in the study group (p < 0.05). Moreover, the number of cases requiring blood transfusion before the operation was significantly higher in the study group (p < 0.05) as were the rates of smoking, previous uterine surgery and nulliparity (p < 0.05). The most common gynecological condition accompanying adenomyosis was found to be uterine myoma in both groups, but the difference was not significant. Conclusion: Adenomyosis is not a rare histopathological finding. Due to diagnostic and therapeutic methods which are being developed as an alternative to hysterectomy, the clinical effects of adenomyosis and its association with other gynecological conditions, adenomyosis appears to be an issue which will be more intensively investigated in the future.Öğe Clinical symptoms and histopathological findings in subjects with adenomyosis uteri(I R O G Canada, Inc, 2008) Cirpan, T.; Yeniel, O.; Ulukus, M.; Ozbal, A.; Gundem, G.; Ozsener, S.; Itil, I. Mete; Zekioglu, O.Objective: The purpose of this study was to compare the clinical symptoms and histopathological findings in subjects with adenomyosis uteri. Method: Infiltration depth and spread of adenomyotic foci together with clinical symptoms and findings were compared in a total of 103 subjects who had undergone hysterectomy and were diagnosed with adenomyosis uteri through histopathological examinations. Results: The spread of adenomyotic foci in myometrial tissues was observed to significantly increase as the depth of myometrial infiltration increased in subjects with adenomyosis (p < 0.05). It was observed that there was significantly higher myometrial infiltration depth in subjects with dysmenorrhea and severe anemia, and diffuse adenomyotic foci in subjects with menometrorrhagia (p < 0.05). Conclusion: Increased infiltration depth and spread of adenomyotic foci in myometrial tissues in subjects with adenomyosis uteri were studied. When clinical symptoms and findings in subjects with adenomyosis, such as dysmenorrhea, anemia and menometrorrhagia are compared with these histopathological findings, infiltration depth and spread of adenomyotic foci appear to determine the clinical severity of adenomyosis.Öğe Does impaired thyroid function or antithyroid antibodies influence success rates in assisted reproductive technologies?(Elsevier Science Inc, 2006) Akdogan, A.; Tavmergen, E. G.; Ulukus, M.; Barut, C.; Levi, R.; Tavmergen, E.Öğe Effects of inherited trombophilia in women with recurrent pregnancy loss(I R O G Canada, Inc, 2011) Habibovic, Z.; Zeybek, B.; Sanhal, C.; Eroglu, Z.; Karaca, E.; Ulukus, M.Purpose of Investigation: To evaluate the prevalence and effects of inherited thrombophilia caused by factor V Leiden, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations in women with recurrent pregnancy loss. Methods: A study group of 97 women with recurrent miscarriages and a control group of 71 healthy pregnant women were included in the study. Genotype analyses for factor V Leiden, prothrombin G20210A and MTHFR C677T polymorphisms were performed by real-time polymerase chain reaction (RT-PCR). Results: The frequency of factor V Leiden, prothrombin G20210A and MTHFR C677T mutations were similar in both the study and control group. There were eight patients (8.2%) who had more than one gene mutation in the study group and one patient in the control group (1.4%). This difference was not statistically significant. Study group patients (n = 97) were compared in terms of the number of miscarriages and the abortion week, in addition to being a carrier of factor V Leiden and MTHFR C677T gene mutations. No statistically significant correlation was found between being a factor V Leiden and MTHFR C677T mutation carrier with either the number of miscarriages or the abortion week. Conclusion: Factor V Leiden, prothrombin G20210A and MTHFR C677T gene mutations are not individually related with recurrent pregnancy loss. However, combined gene mutation status may be associated with recurrent miscarriages.Öğe Immunohistochemical evaluation of cell proliferation and apoptosis markers in ovaries and uterus of tamoxifen-treated rats(Blackwell Publishing, 2008) Cirpan, T.; Terek, M. C.; Ulukus, M.; Ulukus, E. C.; Akman, L.; Kanit, L.The aim of the study was to evaluate the immunohistochemical expression of cell proliferation and apoptosis markers in the ovaries and uterus of tamoxifen-treated rats. Twelve rats (150-200 g) were divided into two equal groups. The study group received daily intraperitoneal injections of tamoxifen dissolved in 5% dimethyl sulfoxide (n = 6). The control group received only the vehicle (n = 6). The rats were sacrificed at the 20th day of injection and were perfused. The ovaries and uterus of the rats were extracted. The sections were immunohistochemically stained with cell proliferation marker Ki-67 and the apoptosis markers PTEN and CD95. The expressions of the markers were quantified by a semiquantitative H-score method in myometrium, endometrial glands, ovarian surface epithelium, ovarian follicles, corpus luteum, and ovarian stroma separately. The mean H-scores of CD95 and PTEN obtained from myometrium, glandular endometrium, ovarian surface epithelium, ovarian follicles, corpus luteum, and ovarian stroma did not show significant difference between the study and the control groups. Proliferative index (Ki-67) of endometrial glands was significantly higher in the study group than in the control group (P < 0.05). In addition, proliferative index (Ki-67) of corpus luteum was significantly higher in the study group than in the control group (P < 0.05). Tamoxifen treatment has a potential to stimulate the cell proliferation of endometrial glands and corpus luteum in tamoxifen-treated rats. Apoptosis markers of PTEN and CD95 did not demonstrate significant difference after the tamoxifen treatment.Öğe Surgically induced endometriosis in a rat model: regression of implant volume, decreasing cytokines levels, histological changes with oxytocin treatment(Oxford Univ Press, 2012) Yeniel, A.; Erbas, O.; Ergenoglu, A.; Aktug, H.; Taskiran, D.; Yildirim, N.; Ulukus, M.Öğe Vulvar Endometrioma: A Case Report(Nepal Medical Assoc, 2011) Turan, V; Ergenoglu, M.; Yeniel, O.; Emiroglu, G.; Ulukus, M.; Zekioglu, O.Endometriosis is a benign and common disorder that is characterized by ectopic endometrium outside the uterus. Extrapelvic endometriosis, like of the vulva, is rarely seen. We report a case of a 47-year-old woman referred to our clinic due to complaints of a vulvar mass and periodic swelling of the mass at the time of menstruation. During surgery, the cyst ruptured and a chocolate-colored liquid escaped onto the surgical field. The cyst was extirpated totally. Hipstopathological examination showed findings compatible with endometriosis. She was asked to follow-up after three weeks. The patient had no complaints and the incision field was clear at the follow-up.
