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    The angiographic correlation between ST segment depression in noninfarcted leads and the extent of coronary artery disease in patients with acute inferior myocardial infarction: A clue for multivessel disease
    (Elsevier Science Inc, 2003) Zoghi, M; Gurgun, C; Yavuzgil, O; Turkoglu, I; Kultursay, H; Akilli, A; Akin, M; Turkoglu, C
    BACKGROUND: Although reciprocal ST segment depression (RSTD) in patients with acute inferior myocardial infarction is a common electrocardiogram finding, its significance is not yet established. In this prospective study, the relationship between RSTD and the extent of coronary artery disease (CAD) was investigated. PATIENTS AND METHODS: One hundred eighty-eight patients with acute inferior myocardial infarction who received thrombolytic therapy were enrolled in this study. The magnitude and location of ST segment depression in noninfarcted leads and the maximum ST segment elevation (STEmax) in inferior leads were measured. All patients were divided into two main groups according to the presence of RSTD and five subgroups according to the location of RSTD, the maximum RSTD and the STEmax. The coronary angiography was performed in all patients 28 4 days after acute myocardial infarction. RESULTS: There were no significant differences in the proportion of coronary disease risk factors in patients with, versus those without, RSTD (P=0.6). Multivessel CAD was present in 63 of the 108 (58%) patients with RSTD and in 32 of the 80 (40%) patients with no RSTD (P=0.02). According to the location of reciprocal changes, multivessel disease was present in significantly more patients with anterior RSTD concomitant with or without lateral ST segment depression (P=0.01 and P=0.03, respectively); the proportion of single vessel disease was greater in patients with only lateral RSTD (P=0.02). In addition, the presence of anterior RSTD to a greater magnitude than the STEmax in inferior myocardial infarction increases the likelihood of multivessel disease (P=0.006). CONCLUSIONS: The presence of RSTD during an acute inferior myocardial infarction correlates with the presence of multivessel CAD and may not be only an electrical phenomenon.
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    The angiographic correlation between ST segment depression in noninfarcted leads and the extent of coronary artery disease in patients with acute inferior myocardial infarction: A clue for multivessel disease
    (Elsevier Science Inc, 2003) Zoghi, M; Gurgun, C; Yavuzgil, O; Turkoglu, I; Kultursay, H; Akilli, A; Akin, M; Turkoglu, C
    BACKGROUND: Although reciprocal ST segment depression (RSTD) in patients with acute inferior myocardial infarction is a common electrocardiogram finding, its significance is not yet established. In this prospective study, the relationship between RSTD and the extent of coronary artery disease (CAD) was investigated. PATIENTS AND METHODS: One hundred eighty-eight patients with acute inferior myocardial infarction who received thrombolytic therapy were enrolled in this study. The magnitude and location of ST segment depression in noninfarcted leads and the maximum ST segment elevation (STEmax) in inferior leads were measured. All patients were divided into two main groups according to the presence of RSTD and five subgroups according to the location of RSTD, the maximum RSTD and the STEmax. The coronary angiography was performed in all patients 28 4 days after acute myocardial infarction. RESULTS: There were no significant differences in the proportion of coronary disease risk factors in patients with, versus those without, RSTD (P=0.6). Multivessel CAD was present in 63 of the 108 (58%) patients with RSTD and in 32 of the 80 (40%) patients with no RSTD (P=0.02). According to the location of reciprocal changes, multivessel disease was present in significantly more patients with anterior RSTD concomitant with or without lateral ST segment depression (P=0.01 and P=0.03, respectively); the proportion of single vessel disease was greater in patients with only lateral RSTD (P=0.02). In addition, the presence of anterior RSTD to a greater magnitude than the STEmax in inferior myocardial infarction increases the likelihood of multivessel disease (P=0.006). CONCLUSIONS: The presence of RSTD during an acute inferior myocardial infarction correlates with the presence of multivessel CAD and may not be only an electrical phenomenon.
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    Cardiovascular involvement in Behcet's disease
    (Japan Heart Journal, Second Dept Of Internal Med, 2002) Gurgun, C; Ercan, E; Ceyhan, C; Yavuzgil, O; Zoghi, M; Aksu, K; Cinar, CS; Turkoglu, C
    The incidence and nature of cardiac involvement in Behcet's disease are not yet clearly documented. We first used transesophageal echocardiography in combination with resting and signal averaged electrocardiography to define cardiac involvement in Behcets patients. Transthoracic and multiplane transesophageal echocardiography, and resting and signal averaged electrocardiography were performed in 35 Beh et's disease patients (9 women and 26 men, mean age: 38 12 years) and 30 normal subjects. Higher incidences of interatrial septum aneurysm (31% to 6%), mitral valve prolapse (25% to 3%), mitral regurgitation (40% to 6%) and aneurysmal dilatations of sinus valsalva and ascendan aorta were observed in the Beliget's disease patients than in the normal subjects. Mean QT dispersion and mean corrected QT dispersion values were significantly greater in the patients with Beliget's disease. Patients with interatrial septum aneurysm (and/or PFO), valvular dysfunction or proximal aorta dilatation had greater QT dispersion values than thase without these pathologies in the Behqet's group (63+/-11 vs 44+/-19 ms, 58+/-23 vs 41+/-24 and 60 27 vs 42 23 ms respectively, P<0.05). Positive signal averaged electrocardiography parameters were detected in 18 (51%) Beh et's disease patients compared with one (3%) in controls (P<0.001). Dilatation of the proximal aorta, interatrial septal aneurysm, mitral valve prolapse, and mitral regurgitation are the common findings of cardiac involvement in Beliget's disease. Increased dispersion of ventricular repolarisation and positive late potentials are also detected. QT dispersion is significantly higher in patients with these cardiac abnormalities. These findings suggest that cardiac involvement in this disorder is a diffuse process which involves both cardiac structure and vascular elements.
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    Combination Therapy With Verapamil and Nitrendipine In Patients With Hypertension
    (Stockton Press, 1993) Nalbantgil, I; Onder, R; Kiliccioglu, B; Turkoglu, C
    Forty patients with mild to moderate hypertension were divided into two groups, 20 patients (group A) received 240 mg verapamil and 20 patients (group 8) received 20 mg nitrendipine dally during the first six weeks. During the second six weeks, all 40 patients were given 10 mg nitrendipine plus 120 mg verapamil. After the combination therapy, group B received verapamil, 240 mg and group A nitrendipine 20 mg for a further period of six weeks. When verapamil and nitrendipine were used alone, BP decreased significantly in each group. However, BP decreased more when the combination therapy was used and increased when the treatment was changed to single drug therapy from the two-drug combination. In addition, side-effects were three to four times fewer during the combination therapy. It is concluded that the combination of two different calcium antagonists in the treatment of hypertension provides a new dimension to therapy.
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    The combined use of pravastatin with thrombolytic agents in acute myocardial infarction: Results of clinical and angiographical follow-up
    (Elsevier Science Inc, 2000) Kayikcioglu, M; Turkoglu, C; Can, L; Payzin, S; Kultursay, H
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    Does serum HDL-cholesterol level predict coronary bypass graft patency?
    (Elsevier Sci Ireland Ltd, 1999) Kayikcioglu, M; Yavuzgil, O; Can, L; Kultursay, H; Akin, M; Turkoglu, C
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    Early use of pravastatin in patients with acute myocardial infarction undergoing coronary angioplasty
    (Taylor & Francis Ltd, 2002) Kayikcioglu, M; Can, L; Kultursay, H; Payzin, S; Turkoglu, C
    Aim - To determine whether statin therapy initiated early in acute myocardial infarction together with thrombolytic therapy in patients with acute myocardial infarction results in clinical benefit through early plaque stabilization. Methods and results - The study population consisted of 77 patients who underwent coronary balloon angioplasty of the infarct-related artery during the first month of acute myocardial infarction. These patients belonged to the cohort of the Pravastatin Turkish Trial (PTT). Forty of them were assigned randomly to have immediate pravastatin (40 mg/day) therapy adjunctive to thrombolytic therapy regardless of serum lipid levels and received statin treatment throughout the study. Lipid levels were determined immediately after admission and before angioplasty and at the end of 6 months. Patients were re-evaluated clinically and angiographically for cardiovascular adverse events and restenosis after a 6-month follow-up period. The baseline angiographic and clinical characteristics of the two groups were similar. The incidence of angina was significantly lower in the pravastatin group (30.0%, 12 patients) compared to the control group (59.5%, 22 patients) (p = 0.018). The cumulative major adverse cardiac events in the pravastatin group were significantly lower when compared to the control group (32.5% vs. 75.6%, p = 0.0001). Conclusions - Early initiation of pravastatin therapy immediately after an acute myocardial infarction significantly decreased the frequency of major cardiac adverse events. Such early potential clinical benefits further strengthen the rationale for starting statin treatment as soon as possible after acute coronary events particularly in patients in whom invasive intervention is planned.
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    Echocardiographic Analysis of Propranolol Effects on Myocardial-Contractility and Left-Ventricular Function In Normals and Patients With Ischemic-Heart-Disease
    (Japan Circulation Soc, 1982) Turkoglu, C; Numano, F; Sekine, M; Koyama, T; Nishiyama, K; Yajima, M; Numano, F; Maezawa, H
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    The effect of atorvastatin on platelet function in patients with coronary artery disease
    (Acta Cardiologica, 2004) Tekten, T; Ceyhan, C; Ercan, E; Onbasili, AO; Turkoglu, C
    Background-Lipid-lowering therapy was shown to have several beneficial effects in patients with coronary artery disease (CAD). Aim-The objective of this study was to investigate the effect of atorvastatin on platelet aggregation in patients with CAD. Methods-Twenty-five hypercholesterolaemic patients who had angiographically proven CAD and 16 normal subjects were enrolled. All patients received 10 mg/day atorvastatin for two months. Anti-platelet agents were discontinued 15 days prior to blood sampling at the beginning and at the end of the atorvastatin therapy. Aggregometric curves of the platelets in response to ADP, collagen and epinephrine were obtained using the aggregometry (turbidimetric) technique. Results-In patients with CAD, total cholesterol (TC) and LDL cholesterol (LDL-C) basal levels were measured (230 +/- 49 mg/dl, 140 +/- 41 mg/dl, respectively). Following lipid-lowering therapy, TC and LDL-C decreased significantly (p < 0.05). The activation measurements of aggregometric curves decreased significantly compared with basal parameters in response to ADP but not in response to collagen and epinephrine. Conclusion-Lipid-lowering therapy with the HMG-CoA reductase inhibitor, atorvastatin, had a marked reduction effect on platelet aggregation.
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    The effect of cholesterol lowering therapy with atorvastatin on flow-mediated vasodilatation in patients with hypercholesterolaemic coronary artery disease
    (W B Saunders Co Ltd, 2000) Ercan, E; Gurgun, C; Ceyhan, C; Zoghi, M; Akilli, A; Payzin, S; Can, L; Akin, M; Turkoglu, C
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    Effect of coronary balloon angioplasty on plasma soluble P-selectin levels.
    (Excerpta Medica Inc, 1999) Kultursay, H; Kayikcioglu, M; Can, L; Payzin, S; Akilli, A; Turkoglu, C
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    The effect of exercise on P-wave and QT dispersion in coronary artery disease: an angiographic correlation
    (W B Saunders Co Ltd, 2000) Zoghi, M; Gurgun, C; Ozerkan, F; Ercan, E; Yavuzgil, O; Akilli, A; Payzin, S; Turkoglu, C; Akin, M
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    The effect of myocardial surgical revascularization on left ventricular late potentials
    (Futura Publ Co, 2001) Can, L; Kayikcioglu, M; Halil, H; Kultursay, H; Evrengul, H; Kumanlioglu, K; Turkoglu, C
    Background: The presence of ventricular late potentials (LP) is an important indicator for the development of ventricular tachyarrhythmias due to ischemic heart disease. The effect of myocardial revascularization on LP has remained controversial. The purpose of this study was to determine whether complete myocardial surgical revascularization (CABG) documented by myocardial perfusion scintigraphy might alter the substrate responsible for LP. Methods: Prospectively, enrolled patients undergoing elective CABG were evaluated with thallium-201 myocardial perfusion scintigraphy and signal- averaged ECG pre- and postoperatively. SAECG recordings were obtained serially: before, 48-72 hours and 3 months after CABG. LPS were defined as positive if SAECG met at least two of Comes criteria. Scintigraphies were performed pre- and 3 months postoperatively for determination of the success of revascularization. Changes observed in SAECG recordings after CABG were compared between those with and without successful revascularization. Results: CABG resulted in successful revascularization in 23 patients and was unsuccessful in 17 (no change or deterioration of the perfusion defects). Preoperative SAECG values were not different between groups except for RMS values. The incidence of LP decreased significantly postoperatively in patients with improved myocardial perfusion, whereas there were no changes in patients who did not have postoperative perfusion improvement (McNemar test, P < 0.05). Conclusions: LPs disappear following the elimination of myocardial ischemia by complete surgical revascularization. Persistence of ischemia following CABG usually results in the persistence of late potentials. The incidence of ventricular arrhythmias is expected to be unchanged in these patients and they should be reevaluated for reinterventions.
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    The effect of two different pacing modes on global left-ventricular performance in patients with atrioventricular block: a tissue Doppler echocardiography study
    (W B Saunders Co Ltd, 2003) Zoghi, M; Yavuzgil, O; Nalbantgil, S; Ozerkan, F; Akilli, A; Turkoglu, C; Kultursay, H; Akin, M
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    The effect of two different pacing modes on global left-ventricular performance in patients with atrioventricular block: a tissue Doppler echocardiography study
    (W B Saunders Co Ltd, 2003) Zoghi, M; Yavuzgil, O; Nalbantgil, S; Ozerkan, F; Akilli, A; Turkoglu, C; Kultursay, H; Akin, M
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    The effect of type II diabetes mellitus on platelet aggregation in patients undergoing coronary angioplasty
    (W B Saunders Co Ltd, 2000) Sagcan, A; Kayikcioglu, M; Akin, M; Can, L; Ozerkan, F; Turkoglu, C
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    Fibrate therapy in diabetic and non-diabetic patients with combined hyperlipidemia
    (Elsevier Sci Ireland Ltd, 1999) Kayikcioglu, M; Ozerkan, F; Can, L; Kultursay, H; Soydan, I; Turkoglu, C
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    Homozygous factor V Leiden mutation in two siblings presenting with acute myocardial infarction: a rare cause of myocardial infarction in the young
    (Lippincott Williams & Wilkins, 2005) Kayikcioglu, M; Hasdemir, C; Eroglu, Z; Kosova, B; Can, LH; Ildizli, M; Yavuzgil, O; Payzin, S; Turkoglu, C
    Although factor V Leiden mutation, is the most common established genetic risk factor for venous thrombosis, its effect on the development of myocardial infarction remains unclear. We describe a family case of homozygous factor V Leiden mutation in two siblings presenting with acute myocardial infarction as a rare cause of myocardial infarction in the young. (C) Lippincott Williams & Wilkins
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    Large inferoposterior wall pseudoaneurysm - of the left ventricle with a thrombus after myocardial infarction
    (Texas Heart Inst, 1999) Ozerkan, F; Gurgun, C; Zoghi, M; Yavuzgil, O; Turkoglu, C
    A 70-year-old man was admitted to our coronary care unit with severe dyspnea, nonproductive cough, and palpitations 1 month after an inferoposterolateral myocardial infarction. Two-dimensional echocardiography demonstrated severe left ventricular dysfunction and a large (6.6 x 7.9 cm) inferoposterior wall pseudoaneurysm of the left ventricle with a thrombus (Fig, 1). Electrocardiography showed QS formation in leads II, III, aVF, and V-5,V-6; Rs in V-1; and sustained ventricular tachycardia (Fig. 2). The patient refused such interventions as coronary angiography and surgery. His symptoms of heart failure and arrhythmia were relieved by medical therapy He was discharged from the hospital ar his request, and his wife found him dead in his bed 3 weeks later.
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    Low Prevalence of Mitral-Valve Prolapse In Bipolar Affective-Disorder
    (Munksgaard Int Publ Ltd, 1986) Ozeren, A; Turkoglu, C; Saygili, R