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    The Effect of HFE Polymorphisms on Cardiac Iron Overload in Patients with Beta-Thalassemia Major
    (Informa Healthcare, 2013) Turedi, Aysen; Oymak, Yesim; Mese, Timur; Yaman, Yontem; Bayraktaroglu, Selen; Alpman, Asude; Özkınay, Ferda; Aydinok, Yesim; Vergin, Canan
    Objective: We aimed to investigate the effect of human hemochromatosis protein (HFE) polymorphisms on cardiac iron overload in patients with beta-thalassemia major. Methods: Our study included 33 patients diagnosed with beta-thalassemia major who were treated with regular transfusions and chelation therapy. M-mode, tissue Doppler, and pulsed wave Doppler echocardiography were performed on all patients. T2* magnetic resonance imaging (MRI) scans were also performed. The HFE polymorphisms (H63D, C282Y, S65C, Q283P, E168Q, E168X, W169X, P160delC, Q127H, H63H, V59M, and V53M) were studied using polymerase chain reaction. Results: The H63D polymorphism was detected in six patients with beta-thalassemia major. Five patients were heterozygous for the H63D polymorphism, while one was homozygous. There were no other polymorphisms. There was no relationship between the HFE polymorphisms and either the serum ferritin levels or the T2-weighted MRI values (P>.05). Moreover, conventional echo and tissue Doppler echo findings were not correlated with the HFE polymorphisms. Pulmonary vein atrial reversal flow velocity, which is a manifestation of diastolic dysfunction measured with pulse wave echo, was higher in the patients with HFE polymorphisms (P=.036). Conclusions: The HFE polymorphisms had no effect on cardiac iron overload. However, pulmonary vein atrial reversal flow velocity measurements can provide important information for detecting diastolic dysfunction during cardiac follow-up of patients with HFE polymorphisms. Studies with more patients are needed to provide more information regarding this matter.
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    FREQUENCY OF METABOLIC SYNDROME AND THE ROLE OF RADIOTHERAPY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA WHO COMPLETED THERAPY
    (Wiley-Liss, 2010) Oymak, Yesim; Turedi, Aysen; Yaman, Yontem; Buyukinan, Muammer; Ozek, Gulcihan; Cetingul, Nazan; Vergin, Canan
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    Higher Expression of the Novel Gene Upregulated Gene 4 in Two Acute Lymphoblastic Leukemia Patients with Poor Prednisolone Response
    (Karger, 2012) Oymak, Yesim; Dodurga, Yavuz; Turedi, Aysen; Yaman, Yontem; Ozek, Gulcihan; Carti, Ozgur; Gunes, Burcak Tatli; Erbudak, Esin; Berber, Ergul; Avci, Cigir Biray; Vergin, Canan
    Elucidation of the molecular mechanisms of leukemogenesis is important for a better understanding of the prognosis of acute lymphoblastic leukemia (ALL). Studies have shown that the expression of upregulated gene 4 (URG4), which promotes cell growth and survival, is increased in different types of carcinomas including hepatocellular carcinoma, gastric cancer and osteosarcoma. Similarly, higher expression of URG4 and cyclin D1 gene might promote proliferation of the blast cells by causing escape from the G1 checkpoint and entry into the S phase. This study reports the high expression level of URG4 in 2 high-risk ALL patients for the first time in the literature. In conclusion, the higher expression of URG4 in our 2 patients suggests that URG4 might be involved in leukemogenesis. Future studies with a large number of high-risk ALL patients and cell culture studies are needed to demonstrate the exact role of URG4 in leukemogenesis. Copyright (C) 2012 S. Karger AG, Basel