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Öğe Acquisition time: A key point of hepatitis C virusrelated liver disease in renal transplant recipients(2012) Turan I.[No abstract available]Öğe In vitro fertilization-induced pregnancies predispose to gastroesophageal reflux disease(SAGE Publications Ltd, 2016) Turan I.; Kitapcioglu G.; Goker E.T.; Sahin G.; Bor S.Background: Women conceiving following in vitro fertilization (IVF) likely have a variety of risk factors that predispose them to gastroesophageal reflux disease (GERD) in the future. Objective: We aimed to investigate whether pregnancy through IVF may predispose to subsequent GERD compared with pregnancies without IVF. We also evaluate whether twin IVF pregnancies lead to additional risk for having GERD compared with singleton IVF pregnancies. Methods: A validated reflux questionnaire was administered to 156 women with singleton (n=102) or twin (n=54) IVF birth (IVF group) and 111 women with a naturally conceived singleton birth (control group). All women included in the study were primiparas who had given birth at least 1 year prior to data collection. The diagnosis of GERD was based on the occurrence of typical symptoms (heartburn, regurgitation, or both) at least once a week. Results: The prevalence of GERD was 13.5% and 4.5% in IVF and control groups (p=0.015); in the IVF group, this was slightly higher, but not statistically significant, in women with twin compared with singleton pregnancies (14.8% vs. 12.7%, p=0.749). Logistic regression analysis showed that IVF was strongly associated with subsequent GERD (OR, 3.30; 95% CI 1.20–9.04; p=0.02). Conclusion: The risk of developing GERD at least 1 year after delivery increased following IVF. Long-term follow-up studies are required to determine whether therapy during pregnancy can prevent this risk. © Author(s) 2016.Öğe Prevalance of fecal incontinence and its effect on quality of life in elderly individuals living in nursing homes in the city of Izmir [İzmi·r huzurevleri·ndeki· yaşlilarda fekal i·nkonti·nans sikligi ve yaşam kali·tesi· üzeri·ne etki·si·](2008) Dedeli Ö.; Fadiloglu Ç.; Turan I.; Bor S.Introduction: In this study, it was aimed to determine fecal incontinence prevalance and its effect on quality of life of elderly. Materials and Method: The research was carried out in a sample of a total of 304 elderly individuals who were selected senior citizens residing in three nursing homes within the city of Directorate of Social Services, İzmir between the dates of September 2006-November 2006. Research data was collected by "sociodemographic and bowel habit data form", reliable and valid "Turkish Adaptation of Fecal Incontinence Quality of Life Scale (FIQOLS) and Fecal Incontinence Severity Index (FISI)". Results: 9,5% of elderly in households stated fecal incontinence. The score of elderly's FIQOLS the reason of depression/self perception (12.5±4.6) and embrassment (4.2±2.6) domains were low, their psychosocial statement the most affected. Significant correlation between the FISI and FIQOLQ's domains depression/self perception (r=-0.8 p<0.05) and embrassment was found (r=-0.9 p<0.05). Conclusion: Fecal incontinence in elderly has negative effect on health and quality of life. Indepently from the severity of fecal incontinence type and prevalance, it is necessary to support to the elderly for their feeling well for physical, social, hygenic and psyhologic.Öğe Rare cause of weight loss in a kidney transplant recipient: Iron overload(2014) Yaprak M.; Çeltik A.; Turan I.; Nart D.; Turan M.N.; Sezer T.Ö.; Hoşçoşkun C.; Töz H.Various reasons such as malignancies and chronic infections may cause weight loss in kidney transplant patients. In this report, iron overload as a rare cause of weight loss in a kidney transplant patient is presented. Forty-seven-year-old male patient who transplanted from a deceased donor 5 years ago was hospitalized because of 20kg of weight loss. In medical history, he had history of hemodialysis for 89 months and received 100-300mg of intravenous iron therapy per week before transplantation and transfused eight units of blood. In physical examination, weight and height were 45kg and 185cm, respectively. Respiratory and cardiac auscultation was normal. Laboratory results revealed as follow: glucose 76mg/dL, urea 60mg/dL, creatinine 1.35mg/dL, aspartate aminotransferase 74U/L, alanine aminotransferase 77U/L, C-reactive protein 2.59mg/dL, albumin 3.3g/dL, globulin 3.4g/dL, white blood cells 3200/mm3, hemoglobin 13.1g/dL and platelets 190,000/mm3. Chest and abdominal tomography didn't reveal any pathology. Portal Doppler ultrasound showed signs of early cirrhosis. Viral and autoimmune hepatitis markers were negative. Ferritin was 5300ng/mL and transferrin saturation was 82%. In liver biopsy, hemosiderosis was diagnosed and heterozygous H63D gene mutation was detected. Totally, 19 units of phlebotomy were performed. Liver function tests and serum ferritin decreased gradually. At outpatient follow-up in 6 months, he returned to former weight. In conclusion, there can be several causes of weight loss in kidney transplant patients. Iron overload can come across as a rare cause of weight loss. In these patients, ferritin levels should be checked and diagnosis should be clarified by liver biopsy and gene mutation analysis. © 2014 Informa Healthcare USA, Inc.Öğe A severe case of esophageal ulcer causing a tight stricture despite long-term D-penicillamine treatment [Ein Fall eines ausgeprägten Ösophagusulkus mit Striktur trotz Langzeittherapie mit D-Penicillamin](Springer-Verlag Wien, 2014) Yapali S.; Turan I.; Ozutemiz O.; Tekesin O.D-penicillamine has long been used in the management of rheumatic diseases due to the effects on inhibition of collagen synthesis. Herein, we report a severe case of esophageal ulcer causing a tight stricture extending through the distal esophagus despite the longterm D-penicillamine treatment in a patient with Wilson’s disease. D-penicillamine would theoretically be expected to contribute to the healing of an esophageal ulcer. However, the drug failed to have a favorable outcome, which is notable and worth reporting. © Springer-Verlag Wien 2014.Öğe Telbivudine in liver transplant recipients: Renal protection does not overcome the risk of polyneuropathy and myopathy(John Wiley and Sons Ltd, 2015) Turan I.; Yapali S.; Bademkiran F.; Kose T.; Duman S.; Sozbilen M.; Gunsar F.; Ersoz G.; Akarca U.S.; Ozutemiz O.; Karasu Z.The recently reported benefit of telbivudine for renal function has not been systematically studied in long-term liver transplantation (LT) recipients who are at high risk for renal impairment. We aimed to examine whether switching lamivudine therapy to telbivudine could improve renal function in LT recipients who have impaired renal function. This single-center, prospective cohort study enrolled LT recipients who were on lamivudine for hepatitis B virus (HBV) prophylaxis and who had renal impairment for at least 1 year. Lamivudine was switched to telbivudine. The primary outcome was to evaluate the change in renal function at weeks 12, 24, 36, and 48. The secondary outcomes were to assess the efficacy of telbivudine for HBV prophylaxis and the safety profile of telbivudine in the posttransplant setting. After 45 patients were enrolled, the study was terminated early because of increased rates of polyneuropathy/myopathy. During telbivudine treatment (median, 64 weeks), estimated glomerular filtration rate (eGFR) increased in 34 patients (76%). The improvement in renal function was prominent after 24 weeks of telbivudine treatment. Telbivudine was effective as prophylaxis against HBV recurrence. Twenty-six patients (58%) developed polyneuropathy and/or myopathy. The 1-year estimated incidence of polyneuropathy/myopathy was 28%. Diabetes was the strongest predictor of polyneuropathy/myopathy (hazard ratio, 4.13; 95% confidence interval, 1.49-11.50; P=0.007). In conclusion, although it seems to have a favorable effect in the improvement of renal function and seems to be effective in the prevention of HBV recurrence, the high risk of polyneuropathy and myopathy hampers the use of telbivudine in LT recipients. Liver Transpl 21:1066-1075, 2015. © 2015 AASLD. © 2015 American Association for the Study of Liver Diseases.Öğe An unusual cause of massive upper gastrointestinal bleeding: Dieulafoy's lesion within a giant midesophageal diverticulum.(2008) Turan I.; Ozturk A.; Akarca U.; Ozutemiz O.[No abstract available]
