Yazar "Tunc E." seçeneğine göre listele

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    Cancer and cancer stem cells: New molecular perspectives
    (Begell House Inc., 2019) Gurel C.; Inetas G.; Hortu I.; Tunc E.; Kuscu G.C.; Dindaroglu F.C.; Sahin O.; Buhur A.; Oktema G.
    Cancer, which causes the deaths of millions of people, is an important public health problem worldwide. Despite significant advances in the diagnosis and treatment of cancer, survival rates are still insufficient in progressive cancers. Today, one of the most important reasons for not being able to reach the desired level in the fight against progressive cancer types is cancer stem cells (CSCs). The ineffectiveness of conventional therapies on CSCs has made it necessary to investigate the molecular mechanisms and signaling pathways used in the survival, drug resistance, and metastasis of CSCs. In this context, studies investigating the biology of CSCs suggest that lipid metabolism and extracellular vesicles are critical for understanding the stemness and metastasis of these cells. These studies have demonstrated that a number of molecules play a vital role in resistant to apoptosis in CSCs, including the cellular FLICE-inhibitor protein (c-FLIP), which inhibits TRAIL-induced extrinsic apoptosis. Another important output of these studies is the demonstration of the relationship of the cancer microenvironment in terms of epithelial-mesenchymal transition, which CSCs frequently use in the metastasis process. In addition, studies investigating the differences in glycosylation observed in CSCs and investigating cancer vaccines are promisng. These findings will strengthen our aresnal in the fight against cancer. In this article, we summarize current molecular studies on CSCs, an important target in novel cancer therapies. © 2019 Begell House, Inc.
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    Familial Mediterranean Fever (FMF) in Turkey: Results of a nationwide multicenter study
    (Lippincott Williams and Wilkins, 2005) Tunca M.; Ozdogan H.; Kasapcopur O.; Yalcinkaya F.; Tutar E.; Topaloglu R.; Yilmaz E.; Arici M.; Bakkaloglu A.; Besbas N.; Akpolat T.; Dinc A.; Erken E.; Tirpan K.; Ozer H.T.E.; Soyturk M.; Senturk T.; Balci B.; Ozguc M.; Dundar M.; Akar E.; Ozel D.; Dundar M.; Gunesacar R.; Booth D.R.; Hawkins P.N.; Touitou I.; Aksentijevich I.; Matzner Y.; Arslan S.; Balaban Y.; Batman F.; Bayraktar Y.; Apras S.; Calguneri M.; Duzova A.; Kav T.; Ozaltin F.; Simsek H.; Sivri B.; Tatar G.; Akkoc N.; Kavukcu S.; Soylu A.; Turkmen M.; Unsal E.; Arisoy N.; Caliskan S.; Gogus F.; Masatlioglu S.; Sever L.; Akkok N.; Cakar N.; Kara N.; Kocak H.; Ozalp S.; Bilge I.; Sevinc E.; Gul A.; Kamali S.; Sadikoglu B.; Selcukbiricik F.; Sirin A.; Sucu A.; Bek K.; Bulbul M.; Delibas A.; Demircin G.; Erdogan O.; Oner A.; Mesiha M.; Ozkaya N.; Tekin M.; Demirkaya E.; Erdem H.; Gok F.; Pay S.; Islek I.; Kabasakal Y.; Keser G.; Ozmen M.; Akoglu E.; Atagunduz P.; Direskeneli H.; Temel M.; Tuglular S.; Buyan N.; Bakkaloglu S.; Derici U.; Goker B.; Kalman S.; Ozkaya O.; Dusunsel R.; Gunduz Z.; Poyrazoglu M.H.; Korkmaz C.; Baskin E.; Koseoglu H.K.; Saatci U.; Yucel E.; Coban E.; Yakupoglu G.; Oktem F.; Tunc E.; Cobankara V.
    Familial Mediterranean fever (FMF) is an autosomal recessive disease that is prevalent among eastern Mediterranean populations, mainly non-Ashkenazi Jews, Armenians, Turks, and Arabs. Since a large proportion of all the FMF patients in the world live in Turkey, the Turkish FMF Study Group (FMF-TR) was founded to develop a patient registry database and analyze demographic, clinical, and genetic features. The cohort was composed of 2838 patients (mean age, 23.0 ± 13.33 yr; range, 2-87 yr), with a male:female ratio of 1.2:1. There was a mean period of 6.9 ± 7.65 years from disease onset to diagnosis; the period was about 2 years shorter for each decade since 1981. Ninety-four percent of patients were living in the central-western parts of the country; however, their familial origins (70% from the central-eastern and Black Sea regions) reflected not only the ongoing east to west migration, but also the historical roots of FMF in Turkey. Patients' clinical features included peritonitis (93.7%), fever (92.5%), arthritis (47.4%), pleuritis (31.2%), myalgia (39.6%), and erysipelas-like erythema (20.9%). Arthritis, arthralgia, myalgia, and erysipelas-like erythema were significantly more frequent (p < 0.001) among patients with disease onset before the age of 18 years. Genetic analysis of 1090 patients revealed that M694V was the most frequent mutation (51.4%), followed by M680I (14.4%) and V726A (8.6%). Patients with the M694V/M694V genotype were found to have an earlier age of onset and higher frequencies of arthritis and arthralgia compared with the other groups (both p < 0.001). In contrast to other reported studies, there was no correlation between amyloidosis and M694V homozygosity in this cohort. However, amyloidosis was still remarkably frequent in our patients (12.9%), and it was prevalent (27.8%) even among the 18 patients with a disease onset after age 40 years. Twenty-two patients (0.8%) had nonamyloid glomerular diseases. The high prevalence of vasculitides (0.9% for polyarteritis nodosa and 2.7% for Henoch-Schönlein purpura) and high frequency of pericarditis (1.4%) were striking findings in the cohort. Phenotype II cases (those patients with amyloidosis as the presenting or only manifestation of disease) were rare (0.3% or less). There was a high rate of a past diagnosis of acute rheumatic fever, which suggested a possible misdiagnosis in children with FMF presenting with recurrent arthritis. To our knowledge, this is the largest series of patients with FMF reported from 1 country. We describe the features of the disease in the Turkish population and show that amyloidosis is still a substantial problem.
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    The Findings of Optical Coherence Tomography in two Cases with Morning Glory Syndrome [Morning Glory Sendromlu Iki Olgumuzda Optik Koherens Tomografi Bulgularimiz]
    (Gazi Eye Foundation, 2015) Toyran S.; Oztas Z.; Akay F.; Tunc E.
    To assess the clinical importance of optical coherence tomography (OCT) in morning glory syndrome (MGS). Two eyes of two patients who diagnosed of MGS between May 2013 and June 2014 were evaluated retrospectively. After the complete ophthalmological and systemic examination of the patients, horizontal and vertical B mod OCT images were obtained. In the systemic examination, bicuspid aortic valve and cardiac arrhythmia were detected in the first case. No systemic disease were detected in the second case. Visual acuity was measured ?0.1 in two affected eyes. OCT images of peripapiller and macular area revealed enlargement of optic disc, neurosensorial retinal detachment with schisis-like cavity of inner retina in all eyes. Early detection and long-term follow-up of MGS is crucial to reduce the morbidity of ocular and systemic complications. OCT may usefull tool for diagnosis and follow-up of ocular complications. © 2015 Gazi Eye Foundation. All rights reserved.