Yazar "Tunç E." seçeneğine göre listele
Listeleniyor 1 - 4 / 4
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Criteria sets for primary Sjogren’s syndrome are not adequate for those presenting with extraglandular organ involvements as their dominant clinical features(Springer Verlag, 2017) Kabasakal Y.; Kitapçıoğlu G.; Karabulut G.; Tezcan M.; Balkarlı A.; Aksoy A.; Yavuz Ş.; Yılmaz S.; Kaşifoğlu T.; Kalyoncu U.; Dalkılıç E.; Tufan A.; Mercan R.; Yıldız F.; Şentürk T.; Önen F.; Bes C.; Erken E.; Tunç E.; Kamalı S.; Tarhan E.; Yazıcı A.; Düzgün N.; Bıçakçıgil M.; Yılmaz S.; Özmen M.; Öcal L.; Alibaz-Öner F.; Solmaz D.; Çobankara V.; Nalbant S.; Kasapoğlu Günal E.; Kaşkari D.; Göker B.Patients with primary Sjogren’s syndrome (pSS) may go undiagnosed or be misclassified due to the insidious nature and wide spectrum of the disease. The available several classification criteria emphasize glandular findings. We aimed to analyze the efficiency of various classification criteria sets in patients diagnosed on the clinical basis by expert opinion and to compare those pSS patients who fulfilled these criteria with those who did not. This is a multicenter study in which 834 patients from 22 university-based rheumatology clinics are included. Diagnosis of pSS was made on the clinical basis by the expert opinion. In this study, we only interviewed patients once and collected available data from the medical records. The European criteria, American-European Consensus Group (AECG) and American College of Rheumatology (ACR) Sjogren’s criteria were applied. Majority of the patients were women (F/M was 20/1). The median duration from the first pSS-related symptom to diagnosis was significantly shorter in men (2.5 ± 2.3 vs 4.3 ± 5.9 years) (p = 0 < 0.016). When the European, AECG and ACR Sjogren’s criteria were applied, 666 patients (79.9%) satisfied at least one of them. In total, 539 patients (64.4%) satisfied the European, 439 (52.6%) satisfied the AECG, and 359 (43%) satisfied the ACR criteria. Among the entire group, 250 patients (29.9%) satisfied all and 168 (20.1%) met none of the criteria. The rates of extraglandular organ involvements were not different between patients who met at least one of the criteria sets and those who met none. There is an urgent need for the modification of the pSS criteria sets to prevent exclusion of patients with extraglandular involvements as the dominant clinical features. © 2017, Springer-Verlag Berlin Heidelberg.Öğe Manometric assessment of esophageal motility in patients with primary Sjögren's syndrome(Springer Verlag, 2005) Türk T.; Pirildar T.; Tunç E.; Bor S.; Doğanavşargil E.Objective: The aim of this study was to assess the esophageal motility by manometry in patients with primary Sjögren's syndrome. Methods: Esophageal manometry was carried out in 40 patients with primary Sjögren's syndrome (SS), 15 with rheumatoid arthritis (RA), 15 with RA and secondary SS, and 21 healthy volunteers. Results: We found that the mean lower esophageal sphincter (LES) pressures measured by station pull-through and rapid pull-through techniques were significantly higher in primary SS patients than with healthy controls and RA patients with or without SS (P<0.05). Our study did not show any major differences when comparing the three patient groups (P>0.05). However, peristaltic contraction velocity was lower and peristaltic contraction duration significantly higher at the middle and lower thirds of the esophagus in primary SS patients than in healthy controls (P<0.05). Conclusion: The results of our study support the view that various esophageal motility disorders can be found in patients with primary SS which could be related to an increase in LES pressure. We also found no correlation of the esophageal abnormalities with other factors studied, suggesting that the cause of dysphagia is multifactorial in nature. © Springer-Verlag 2004.Öğe PTPN22 gene polymorphism in Takayasu's arteritis(2008) Sahin N.; Aksu K.; Kamali S.; Bicakcigil M.; Özbalkan Z.; Fresko I.; Özer H.; Akar S.; Onat A.M.; Çobankara V.; Kiraz S.; Öztürk M.A.; Tunç E.; Yücel E.; Ateş A.; Keser G.; Inanc M.; Direskeneli H.; Saruhan-Direskeneli G.Objective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. Methods. Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Results. Detected frequencies of heterozygous genotype (AG) were 5.1% (9/177) in control group and 3.8% (7/181) in TA group (P = 0.61, odds ratio: 0.75, 95% CI: 0.3, 2.0). No association with angiographic type, vascular involvement or prognosis of TA was observed either. Conclusion. The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.Öğe An unusual presentation of Behçet's disease: Intestinal perforation(2001) Pırıldar T.; Keser G.; Tunç E.; Alkanat M.; Tunçyürek M.; Doğanavşargil E.Behçet's disease (BD), when first described in 1937, consisted of three symptoms: recurrent oral and genital ulcerations and iridocyclitis [1]. Today, it is known that BD is a multisystemic chronic vasculitic disorder which may involve both arteries and veins of all sizes, as well as the central nervous and gastrointestinal systems. The rate of gastrointestinal involvement of BD varies in different populations, being more common in Japan (50%-60%) and less common in the Mediterranean basin, including Turkey (0%-5%) [2,3]. We present a 34-year-old Turkish woman with BD who had ileal and colonic ulcerations complicated by perforation and gastrointestinal bleeding. Special emphasis was placed on the differential diagnosis between Crohn's disease (CD) and BD with gastrointestinal involvement.
