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    Assessment of disease activity in large-vessel vasculitis: Results of an international delphi exercise
    (Journal of Rheumatology, 2017) Aydin S.Z.; Direskeneli H.; Merkel P.A.; Toloza S.; Blockmans D.; Sato E.I.; De Souza A.W.S.; Cabral D.; Carette S.; Famorca L.; Khalidi N.; Milman N.; Yacyshyn E.; Tesar V.; Baslund B.; Faurschou M.; Guillevin L.; Puéchal X.; Aries P.; Hellmich B.; Herlyn K.; Holle J.; Lamprecht P.; Moosig F.; Neumann T.; Zwerina J.; Tómasson G.; Bambery P.; Jois R.; Rajasekhar L.; Sharma A.; Sivakumar R.; Molloy E.; Hashkes P.; Catapano F.; Cimino L.; De Fanti A.; Pipitone N.; Salvarani C.; Vaglio A.; Kobayashi S.; Suzuki K.; Flores-Suárez L.F.; Hinojosa-Azaola A.; Brouwer E.; Rutgers A.; Stegeman C.; Suppiah R.; Hollan I.; Arguis P.; Cid M.C.; Daikeler T.; Alibaz-Oner F.; Hamuryudan V.; Hatemi G.; Hazirolan T.; Inanc M.; Kalayci M.B.; Kamali S.; Kansu T.; Karaaslan Y.; Karadag O.; Keser G.; Onat A.M.; Ozbalkan Z.; Ozen S.; Ozer H.T.E.; Pamuk Ö.N.; Yilmaz S.G.; Basu N.; Casian A.; Chakravarty K.; D'Cruz D.; Edelsten C.; Harper L.; Jayne D.; Levy J.; Mason J.; Robson J.; Scott D.; Stanford M.; Watts R.; Albert D.; Amudala N.; Beckman J.; Chacko B.; Chung S.; Fessler B.; Giardino A.; Grayson P.; Hunder G.; Langford C.; Lerman M.; Liang K.; Litt H.; Mason T.; Matteson E.; Mikdashi J.; Mohler E.; Monach P.; Rice B.; Sharma A.; Sreih A.; Stone J.; Tsapatsaris N.; Villa-Forte A.; Warrington K.; Yazici Y.; Ytterberg S.
    Objective. To arrive at consensus for candidate outcomes for disease activity assessment in largevessel vasculitis (LVV) in clinical trials. Methods.A Delphi survey including 99 items was circulated among international experts for 3 rounds. Results. Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging. Conclusion. This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes. Copyright © 2017. All rights reserved.
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    Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database
    (2010) Avouac J.; Walker U.; Tyndall A.; Kahan A.; Matucci-Cerinic M.; Allanore Y.; Miniati I.; Müller A.; Iannone F.; Giacomelli R.; Distler O.; Becvar R.; Sierakowsky S.; Kowal-Bielecka O.; Coelho P.; Cabane J.; Cutolo M.; Shoenfeld Y.; Valentini G.; Rovensky J.; Riemekasten G.; Nicoara I.; Vlachoyiannopoulos P.; Caporali R.; Jiri S.; Inanc M.; Gorska I.Z.; Carreira P.; Novak S.; Czirjak L.; Ramos F.O.; Jendro M.; Chizzolini C.; Kucharz E.J.; Richter J.; Cozzi F.; Rozman B.; Mallia C.M.; Gabrielli A.; Farge D.; Kiener H.P.; Schöffel D.; Sticherling M.; Airo P.; Wollheim F.; Martinovic D.; Trotta F.; Hunzelmann N.; Jablonska S.; Reich K.; Bombardieri S.; Siakka P.; Pellerito R.; Bambara L.M.; Morovic-Vergles J.; Denton C.; Hinrichs R.; Van Den Hoogen F.; Damjanov N.; Kötter I.; Ortiz V.; Heitmann S.; Krasowska D.; Seidel M.; Hasler P.; Van Laar J.M.; Kaltwasser J.P.; Foeldvari I.; Juan Mas A.; Bajocchi G.; Wislowska M.; Pereira Da Silva J.A.; Jacobsen S.; Worm M.; Graniger W.; Kuhn A.; Stankovic A.; Cossutta R.; Majdan M.; Rajcevska L.D.; Tikly M.; Nasonov E.L.; Steinbrink K.; Herrick A.; Müller-Ladner U.; Dinc A.; Scorza R.; Sondergaard K.; Indiveri F.; Nielsen H.; Szekanecz Z.; Silver R.M.; Antivalle M.; Espinosa I.B.; García De La Pena Lefebvre P.; Midtvedt O.; Launay D.; Valesini F.; Tuvik P.; Ionescu R.M.; Del Papa N.; Pinto S.; Wigley F.; Mihai C.; Capranu M.S.; Sunderkötter C.; Jun J.B.; Derk C.; Alhasani S.; Distler J.H.; Ton E.; Soukup T.; Seibold J.; Zeni S.; Nash P.; Mouthon L.; De Keyser F.; Duruöz M.T.; Cantatore F.P.; Strauss G.; Von Mülhen C.A.; Pozzi M.R.; Eyerich K.; Szechinski J.; Keiserman M.; Houssiau F.A.; Rom-Ivorra J.A.; Krummel-Lorenz B.; Aringer M.; Westhovens R.; Bellisai F.; Mayer M.; Stoeckl F.; Üprus M.; Volpe A.; Buslau M.; Yavuz S.; Granel B.; Feijó A.V.; Del Galdo F.; Popa S.; Zenone T.; Machado X.R.; Pileckyte M.; Stebbings S.; Mathieu A.; Tulli A.; Tourinho T.; Souza R.; Acayaba De Toledo R.; Stamp L.; Solanki K.; Veale D.; Neto J.F.M.; Bagnato G.F.; Loyo E.; Toloza S.; Li M.; Mohamed W.A.A.A.; Cobankara V.; Olas J.; Salsano F.; Oksel F.; Tanaseanu C.M.; Foti R.; Ancuta C.; Vonk M.; Caramashi P.; Beretta L.; Balbir A.; Shine B.; Chiàla A.; Simic K.P.; Ghio M.; Stamenkovic B.; Rednic S.; Host N.; Pellerito R.; Hachulla E.; Furst D.E.
    Objective. To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). Methods. This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. Results. We recruited 7286 patients with SSc; their mean age was 56 ± 14 years, disease duration 10 ± 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. Conclusion. Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with amore severe disease and with systemic inflammation. The Journal of Rheumatology Copyright © 2010. All rights reserved.