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Öğe EVALUATION OF CEREBRAL AND MESENTERIC BLOOD FLOW DURING RETINOPATHY OF PREMATURITY EXAMINATIONS(Springer, 2016) Yasar, B. E.; Terek, D.; Ergin, F.; Koroglu, O. Altun; Yalaz, M.; Akisu, M.; Kultursay, N.Öğe IMPACT OF PHARMACOLOGICAL PDA TREATMENT ON THE MESENTERIC AND CEREBRAL CIRCULATION(Springer, 2016) Ergin, F.; Sahan, Y.; Terek, D.; Yalaz, M.; Koroglu, O. Altun; Levent, E.; Akisu, M.; Kultursay, N.Öğe Improved neonatal prognosis following restriction in the number of transferred embryos in assisted reproduction - single center yearly comparison from Turkey(I R O G Canada, Inc, 2015) Kultursay, N.; Koroglu, O. A.; Uygur, O.; Terek, D.; Tannverdi, S.; Akisu, M.; Yalaz, M.Purpose: To evaluate the impact of new legislation for assisted reproductive technology (ART) restricting the number of transferred embryos on neonatal prognosis of infants born after infertility treatments. Materials and Methods: Neonatal records of all live born infants in Ege University Maternity Ward were reviewed for 2006 and 2012. Neonatal outcome measures such as birth weight (BW), gestational age (GA), preterm birth (PTB), very low birth weight (VLBW), and neonatal intensive care unit (NICU) admission were evaluated. Results: Compared to 2006 percentage of newborns conceived by medically assisted reproduction (MAR) decreased from 14.6% to 5% in all live births, from 23.8% to 8.2% in NICU patients in 2012. The number of fetuses in the last pregnancy, frequency of intrauterine reductions, spontaneous pregnancy losses, antenatal bleeding, and premature delivery decreased. Percentage of multiples among MAR newborns (31.7% vs. 55.7%), twins from 51.4% to 30.9%, triplets from 4.3% to 0.8% all decreased significantly. Mean BW and gestational age increased resulting in decreased frequency of PTB and VLBW. Consequently Level 3 NICU admission rate significantly decreased from 44.3% to 22%. Conclusion: The new ART legislation in Turkey resulted in decreased rate of multiple births, prematurity and related complications, and NICU admissions in MAR newborns. However the twin rates are still high. Since uncontrolled ovulation stimulation and intrauterine insemination techniques are also associated with multiple births and unfavorable neonatal outcomes, these procedures deserve close monitorization.Öğe Micafungin Use in Children: A Tertiary Referral Hospital Experience in the Treatment of Invasive Fungal Infections(AVES, 2023) Güner, Özenen, G.; Şahbudak, Bal, Z.; Özek, G.; Bilen, N.M.; Ümit, Z.; Terek, D.; Polat, S.H.Objective: Invasive fungal infections (IFIs) are a major cause of mortality and morbidity in hospitalized pediatric patients due to limited treatment options. Micafungin has been the most recently approved echinocandin for the treatment of IFIs in children; however, the data on efficacy and adverse events in children has been limited. This study aimed to evaluate the characteristics, treatment responses, and the incidence of adverse events of the micafungin treatment in children. Material and Methods: This retrospective study was designed to evaluate all patients under 18 years old who received micafungin for treatment between January 2017-December 2019. A standardized form was used to collect demographic characteristics, underlying medical conditions, diagnosis of fungal infections, laboratory findings, prognosis, and mortality (14-day mortality, 30-day mortality). Results: We evaluated 43 episodes of 39 patients who received mica-fungin for treatment. Median age of the patients who received mica-fungin for treatment was 2.3 (10 days-17 years and six months) years. Micafungin was used for definitive treatment in 18 (41.9%) patients, for empiric treatment in 15 (34.9%) patients, and for febrile neutrope-nia in 10 (23.3%) patients. Median duration of micafungin treatment was 14 (3-53) days. Treatment efficacy was found as 79.1% in clinical response and 81.3% in mycological response. The incidence of hepat-ic adverse events was 20.9% and renal adverse events 2.3% while using micafungin for treatment. In patients who received micafungin for treatment, 14-day and 30-day mortality rates were 7% and 9.3%, respec-tively. However, these deaths were not attributable to a fungal infection (two patients died due to heart failure, and two patients died due to respiratory failure). Conclusion: We demonstrated that micafungin might be a safe and effective antifungal agent for empiric therapy and definitive therapy. Further and more extensive prospective studies to evaluate the efficiency and safety of micafungin in children are needed. © 2023, AVES. All rights reserved.Öğe The net impact of clinical seizures on outcome characteristics in infants with neonatal encephalopathies at 12 months of age(W.B. Saunders Ltd, 2023) Tekgul, H.; Koroğlu, O.A.; Tanrıverdi, M.; Yalaz, M.; Terek, D.; Aktan, G.; Akisu, M.Purpose: To assess the impact of clinical neonatal seizures on outcome characteristics of preterm and term newborns with neonatal encephalopathy (NE). Methods: We designed a prospective comparative study with 53 babies (preterm neonates: 26 and term neonates: 27) with NE: group 1 (preterm neonates with seizures, n = 13), group 2 (preterm neonates without seizures, n = 13), group 3 (term neonates with seizures, n = 13) and group 4 (term neonates without seizures, n = 14). The functional outcome characteristics of the survivors were assessed by the Ankara Developmental Screening Inventory (ADSI) and the Guide for Monitoring Child Development (GMCD) at 12 months of age. Results: Clinically defined acute symptomatic seizures were diagnosed with prompt conventional EEG / amplitude-integrated EEG in preterm (92.3%) and term neonates (81.4%) with etiology-specific diagnoses of NE. There were no differences between the study groups regarding seizure semiology and EEG characteristics. A primary adverse outcome was defined in 22 (41.5%) of the cohort. However, only 15.3% of infants had an unfavorable functional outcome with ADSI at 12 months. Among the survivors, there was no significant difference between the study groups regarding ADSI scores. The GMDC test revealed normal development in 50% of survivors with seizures in the preterm group and 83% in the term group. Conclusion: There was no significant difference between the characteristics of functional outcomes at 12 months in preterm and term neonates with NE for clinical seizures. © 2022Öğe SINGLE VERSUS MULTIPLE DOSES OF SURFACTANT TREATMENT IN PRETERM INFANTS(Springer, 2016) Bilgin, B. Siyah; Koroglu, O. Altun; Terek, D.; Yalaz, M.; Akisu, M.; Kultursay, N.
