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    DETERMINING THE FEASIBILITY OF NUTRITIONAL SCREENING TESTS IN HEMODIALYSIS PATIENTS
    (Oxford Univ Press, 2018) Taban, Gizem; Keskin, Ibrahim; Gokalp, Cenk; Kucukerdonmez, Ozge; Bayrak, Fugen; Akgungor, Ilhan; Malkoc, Malkoc; Taskin, Huseyin; Hur, Ender; Duman, Soner
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    DOES INTERDIALYTIC WEIGHT GAIN EFFECT HEMOGLOBIN VARIABILITY
    (Oxford Univ Press, 2017) Gokalp, Cenk; Hur, Ender; Ulusoy, Merve Gulsah; Duman, Elif; Taskin, Huseyin; Bicak, Selahattin; Timur, Ozge; Buyukoglan, Nese; Ozkan, Necati; Cakir, Ertugrul; Yurtman, Gurcan; Akgungor, Ilhan; Malkoc, Zeki; Duman, Soner
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    THE EFFECTS OF COLCHICINE ON THE PROGRESSION AND REGRESSION OF ENCAPSULATING PERITONEAL SCLEROSIS
    (Multimed Inc, 2008) Bozkurt, Devrim; Bicak, Selahattin; Sipahi, Savas; Taskin, Huseyin; Hur, Ender; Ertilav, Muhittin; Sen, Sait; Duman, Soner
    Background: Encapsulating peritoneal sclerosis (EPS) is an infrequent but extremely serious complication of long-term peritoneal dialysis. Fibrosis of the submesothelial compact zone and neoangiogenesis underlie the pathophysiology of EPS. Colchicine is a well-known anti-inflammatory and antifibrotic agent that has been used for some fibrosing clinical states, such as liver fibrosis. Objective: To determine the antifibrotic and anti-inflammatory effects of colchicine in an EPS rat model in both progression ( P) and regression ( R). Methods: 48 nonuremic albino Wistar rats were divided into 5 groups: control group, 2 mL isotonic saline intraperitoneally (IP) daily for 3 weeks; CG group, IP injection of 2 mL/200 g chlorhexidine gluconate ( CG) (0.1%) and ethanol (15%) dissolved in saline, daily for 3 weeks; resting group, CG (0 - 3 weeks) + peritoneal resting (4 - 6 weeks); C-R group, CG ( 0 - 3 weeks) + 1 mg/L colchicine ( 4 - 6 weeks); C-P group, CG ( 0 - 3 weeks) + 1 mg/L colchicine in drinking water ( 0 - 3 weeks). At the end, a 1-hour peritoneal equilibration test was performed with 25 mL 3.86% peritoneal dialysis solution. Dialysate-to-plasma ratio of urea (D/P urea), dialysate WBC count, ultrafiltration volume, and morphological changes of parietal peritoneum were examined. Result: Exposure to CG for 3 weeks resulted in alterations in peritoneal transport ( increased D/P urea, decreased ultrafiltration volume; p < 0.05) and morphology ( increased inflammation, neovascularization, fibrosis, and peritoneal thickness; p < 0.05). Resting had some beneficial effects on peritoneal derangements; however, once the peritoneum had been stimulated, resting alone was not enough to reverse these pathological changes. Colchicine had more pronounced effects on membrane integrity via decreased inflammation, cell infiltration, and vascularity compared to the resting group. Conclusion: We suggest that colchicine may have therapeutic value in the management of EPS.
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    NATIVE RENAL BIOPSIES PERFORMED IN OLDER ADULTS ARE INCREASING: TWELVE YEARS EXPERIENCE OF EGE UNIVERSITY
    (Gunes Kitabevi Ltd Sti, 2011) Hur, Ender; Bozkurt, Devrim; Taskin, Huseyin; Sarsik, Banu; Sen, Sait; Akcicek, Fehmi; Duman, Soner
    Introduction: Determination of the frequency and prevalence of biopsy proven nephropathies in older adults and adults is important for epidemiological studies. Materials and Method: Predominant glomerulonephritis (GN) in native renal biopsies of adults and older adults (>= 65 years) were evaluated. Results: Among a total of 1702 renal biopsies (males 52%, ages 16-82, mean 40 +/- 15 years), 121 (7%) were performed in persons >= 65 years old. The mean age at the time of renal biopsy increased from 37.3 +/- 16.8 in 1996 to 44 +/- 16.1 years in 2009. The leading indications for biopsy in older and younger age groups were nephrotic syndrome (NS) (46.5% vs. 39.8% respectively), asymptomatic urinary abnormalities (20.9% vs. 33.4% respectively) acute renal failure (15.1% vs. 7.4% respectively) and hematuria (4.7% vs. 10.9% respectively). The etiologies of NS were amyloidosis, membranous GN and focal segmental glomerulosclerosis (FSGS) in both age groups. Primary GN was the predominant etiology in both age groups. Above 65 years, membranous (14.8%) and crescentic (9.9%) GNs were predominant while below 65 years IgA nephropathy (9%) was predominant. Among secondary GNs, amyloidosis (19%) and lupus nephritis (11.7%) were also predominant in the elderly and the younger persons respectively. Conclusion: The current data represents the experience of a single center. Such registries will allow epidemiologic studies to answer several open questions regarding both prevention and treatment of nephropathies in different age groups.
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    Volume status effected by gravity and body fluid shifts: new protocol for bioimpedance measurements
    (Informa Healthcare, 2014) Kose, Sennur Budak; Hur, Ender; Taskin, Huseyin; Bicak, Selahattin; Duman, Soner