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Öğe "Air-bubble" signs in the CT diagnosis of perforated pulmonary hydatid cyst: Three case reports(2008) Zeyrek D.; Savas R.; Gulen F.; Demir E.; Tanac R.Computed tomography is an important imaging modality in the evaluation of hydatid cyst. However, diagnosis of perforated hydatid cyst is very difficult and for this reason some radiological findings have been defined. An important finding is the "air bubble" sign. As a consequence of cyst rupture, secondary bacterial infections like bronchopneumonia or lung abscess may develop which complicate the clinical picture further. In the literature, the "air bubble" sign which is a relatively newly discovered radiological sign is reported to be very sensitive in establishing diagnosis. For this reason, in suspected cases of hydatid cyst, the air bubble sign may aid physicians in establishing diagnosis.Öğe Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma(2008) Zeyrek D.; Demir E.; Alpman A.; Özkınay F.; Gulen F.; Tanac R.Asthma is a complex genetic disease. Genetic and functional characteristics of interleukin (IL)-1 support a role as an asthma locus for the IL-1 family on chromosome 2q12-21. This study was performed to investigate the relationship between polymorphisms of IL-1beta promoter region -511C/T and IL-1 receptor antagonist (IL-1Ra) gene (IL-RN) and bronchial asthma in Turkish children. Children were divided into two groups: (1) bronchial asthma (n = 328) and (2) healthy control (n = 246). Polymerase chain reaction was used to resolve the IL-1beta -511C/T and the IL-1Ra intron 2 polymorphisms. Plasma IgE concentrations were measured by immunoassays, and skin-prick tests were done in children with atopic diseases. The number of genotype CC and C allele in the control groups in IL-1beta -511C/T polymorphisms increased. The number of genotype 1/1 in the asthma groups and genotypes 1/2 and 5/5 and 5 allele in the control groups in IL-1Ra intron 2 gene polymorphism increased. Serum spIgE level increased in the 2/2 genotype in the asthma groups in IL-1Ra intron 2 gene polymorphism. Based on these results, we conclude that there was an association of pediatric asthma with the IL-1beta -511C/T and IL-1Ra intron 2 gene polymorphism. Based on these findings, it has been proposed that IL-1beta -511C/T and IL-Ra intron 2 gene polymorphism are useful markers for prediction of asthma. Copyright © 2008, OceanSide Publications, Inc., U.S.A.Öğe Comparison of three methods of inhaling salbutamol in acute childhood asthma(1995) Coker M.; Tanac R.Inhalation therapy with salbutamol sulphate was administered to 36 patients with acute asthma. The effect of salbutamol inhaled by three different methods were compared in three groups each consisting of 12 children. These methods were metered dose inhaler (MDI) with or without spacer and compressed nebuliser respectively. All patients were standardized by respiratory score. Respiratory score, peak expiratory flow rate (PEFR) with a wright peak flow meter, respiration rate, heart rate and blood pressures were measured before and during the six hours after inhalation therapy. These methods of inhalation therapy were satisfactory at the end of 6 hours. Treatment of acute asthma using a nebuliser was found to be significantly more successful compared to other methods (p < 0.01). Complications were not seen in any of the inhalation techniques.Öğe Effect of nedocromil sodium on invivo and invitro secretion of lipid mediators from peripheral leukocytes of asthmatic children(1997) Huseyinov A.; Yuksel H.; Tanac R.; Demir E.; Coker I.[No abstract available]Öğe The Fc?RIIa polymorphism in Turkish children with asthma bronchial and allergic rhinitis(2007) Gulen F.; Tanac R.; Altinoz S.; Berdeli A.; Zeyrek D.; Koksoy H.; Demir E.Objective: The aim of the present study was to evaluate the Fc?RIIa polymorphism in Turkish children with atopic asthma and allergic rhinitis. Design and methods: In this study, 372 atopic children (192 asthma bronchial, 180 allergic rhinitis) between ages of 5 and 16 years old (11.3 ± 2.9) who were followed at Aegean University Paediatric Allergy and Pulmonology Outpatient Clinics and 234 healthy subjects as the control group were included. The evaluation of subjects included routine biochemical blood analysis and allergic workup based on the following laboratory determinants. The Fc?RIIa polymorphism was determined using the polymerase chain reaction method. Results: Distribution of R131R genotype was significantly different among patient groups compared to controls (for asthmatic children OR: 2.64 95%CI: 1.22-5.79, p = 0.006; for allergic rhinitis OR: 2.58 95%CI: 1.18-5.71, p = 0.009). Frequency of 131R allele was significantly different among patient groups compared to controls (for asthmatic children OR: 1.66 95%CI: 1.22-2.26, p = 0.0007; for allergic rhinitis OR: 1.93 95%CI: 1.42-2.63, p = 0.00001). Conclusion: This study shows that Fc?RIIa gene 131R allele represents an important genetic risk factor for bronchial asthma and allergic rhinitis susceptibility. © 2007 The Canadian Society of Clinical Chemists.Öğe Fc?RIIIa-V/F 158 polymorphism in Turkish children with asthma bronchiale and allergic rhinitis(2008) Zeyrek D.; Tanac R.; Altinoz S.; Berdeli A.; Gulen F.; Koksoy H.; Demir E.Fc receptors (FcR) play an important role in immune regulation. This might be linked to the variability in immune response, therefore relating to the pathogenesis of atopic diseases. The aim of the present study was to evaluate the Fc?RIIIa gene polymorphism in Turkish children with asthma and allergic rhinitis. The study included 364 atopic children (184 bronchial asthma, 180 allergic rhinitis) and 234 healthy subjects as the control group, aged between 5 to 16 years. Patients were recruited from outpatient clinics of allergy and general pediatric care. Plasma IgE concentrations were measured by immunoassays and skin prick test was done in children with atopic diseases. The Fc?RIIIa gene polymorphism was determined using the polymerase chain reaction method. Distribution of V158V genotype was significantly different among patient groups compared to controls (for asthmatic children OR: 5.33, 95% CI: 2.80-10.23, p < 0.001; for allergic rhinitis OR: 3.25, 95% CI: 1.75-6.07, p = 0.001). Distribution of 158 V allele was significantly different among asthmatic children (OR: 2.20, 95% CI: 1.65-2.92, p < 0.001) and allergic rhinitis patients (OR: 1.77, 95% CI: 1.32-2.35, p < 0.001) compared to healthy controls. Our study shows that the V158V genotype in Fc?RIIIa gene polymorphism may be a genetic risk factor for the development of atopic diseases. © 2008 The Authors.Öğe MicroRNA expression profiling in children with different asthma phenotypes(John Wiley and Sons Inc., 2016) Midyat L.; Gulen F.; Karaca E.; Özkınay F.; Tanac R.; Demir E.; Cogulu O.; Aslan A.; Özkınay, Cihangir; Onay H.; Atasever M.An improved understanding of the molecular mechanisms in asthma through exploring the role of microRNAs may offer promise to reveal new approaches for primary prevention and identification of new therapeutic targets in childhood asthma. The primary goal of this study is to identify the microRNAs that play a role in the pathogenesis of asthma in pediatric age group. The secondary goal is to analyze these microRNAs according to the asthma phenotype, atopic status, and severity of the disease exacerbation. To our knowledge, this is the first research project in the literature which studies the relationship between microRNA expression and the severity of childhood asthma. One hundred children between 6 and 18 years old with a diagnosis of asthma, and 100 age-matched healthy children were enrolled in this study, and the analyses of microRNA expression profiles were performed in the Medical Genetics Laboratories of Ege University between November 2009 and June 2010. The expression of 10 microRNAs were shown to be higher in patients with more severe asthma, and the expression of these microRNAs were also found to be higher in patients who present with more severe acute asthma exacerbation symptoms (P<0.001). Also, five microRNAs were found to be expressed more than twofold in allergic patients when compared to non-allergic participants (P<0.001). Asthma is one of the best examples of complex genetic diseases, and further studies, which will investigate the relationship between these microRNA’s and their target genes, are needed to learn more about the specific roles of microRNAs in respiratory diseases. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc.Öğe Molecular genetic analysis of Turkish cystic fibrosis patients(1993) Koprubasi F.F.; Bosch-Al-Jadooa N.; Alkan M.; Tanac R.; Buhler E.; Malik N.The cystic fibrosis (CF) gene was recently cloned and a three basepair deletion removing phenylalanine 508 from the coding region was identified as the mutation on the majority of cystic fibrosis chromosomes. The frequency of this mutation varies among different geographic locations. In this study we analysed 25 Turkish families and have found the relative frequency of the delta F508 (DF508) mutation to be 20.37%. This is similar to that reported in other Middle Eastern countries and contrasts with the considerably higher frequencies encountered in Northern Europe and North America. Molecular analysis of the two nucleotide binding folds (NBFs) of the cystic fibrosis transmembrane conductance regulator (CFTR) gene with direct sequencing, has also shown that the other defined mutations in these regions of the gene do not occur in the CF patients from the Turkish population. One patient presenting with severe clinical features was determined to be a compound heterozygote for the mutations ?F508/1677delTA.Öğe Plasma interleukin-3 and interleukin-4 concentrations in Turkish asthmatic children [2](BMJ Publishing Group, 1995) Kutukculer N.; Ozdogru E.; Demir E.; Tanac R.[No abstract available]Öğe Sinopulmonary aspergillosis in children with hematological malignancy(2006) Gulen H.; Erbay A.; Gulen F.; Kazanci E.; Vergin C.; Demir E.; Tanac R.Invasive pulmonary aspergillosis is a serious infectious complication in immunocompromised especially neutropenic patients. Despite improvements in early diagnosis and effective treatment, invasive pulmonary aspergillosis is still a devastating opportunistic infection. These infections also interfere with the anticancer treatment. We report our experience in the diagnosis and therapeutic management of sinopulmonary aspergillosis in 4 children with hematologic malignancy. All patients except the first were neutropenic when sinopulmonary aspergillosis was diagnosed. Clinical signs included fever, cough, respiratory distress, swallowing difficulty, headache, facial pain-edema and hard palate necrosis. Radiodiagnostic methods showed bilateral multiple nodular infiltrations, soft tissue densities filling all the paranasal sinuses, and bronchiectasis. Diagnosis of aspergillosis was established by bronchoalveolar lavage in one case, tissue biopsy, positive sputum and positive cytology, respectively, in the other 3 cases. One patient was treated with liposomal amphotericin B and other 3 cases were treated with liposomal amphotericin B + itraconozole. Outcome was favorable in all cases except the one who died due to respiratory failure. Early diagnosis, appropriate treatment and primary disease status are important factors on prognosis of Aspergillus infections in children with hematological malignancy.Öğe Urticaria and angioneurotic edema due to the temporary henna tattoo(2006) Gulen F.; Zeyrek D.; Altinoz S.; Peker E.; Demir E.; Tanac R.Temporary henna tattoo, which has become popular among young people, is obtained from the mixture of the plants Lawsonia alba or Lawsonia inermis and paraphenylenediamine (PPD). In forming reactions frequent development of anti-PPD substance is noticed. A 13-year old boy who started itching, erythema, enduration on the application area, increasingly urticarial rash, conjunctivitis and swelling of the lips 48 h after being applied the temporary henna tattoo was hospitalized. He had a local reaction to henna tattoo when he was 5-year old. He was treated with parenteral corticosteroids and oral antihistaminic drugs. Skin reactions persisted for 18 days. The patient showed no early reaction to henna 10% and FPD 1% concentration in saline solution but did late reaction (after 48 h) to PPD in diameter of 12×13 mm in prick test in 3 weeks after the reaction. A case who developed angioneurotic edema and urticaria to temporary henna tattoo noticed that the henna tattoo is not an innocent application and young people need to be informed on this subject.
