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  1. Ana Sayfa
  2. Yazara Göre Listele

Yazar "Tamer, F." seçeneğine göre listele

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  • Küçük Resim Yok
    Öğe
    Assessment of Bone Lesions With Ga(68)PSMA Uptake Without Visible Bone Density Change on Corresponding CT
    (Springer, 2019) Tatlidil, S.; Tamer, F.; Gumus, M.; Ozcan, Z.
    [No abstract available]
  • Küçük Resim Yok
    Öğe
    A Benign Adrenal Mass with Changing Metabolism Mimicking Metastasis During Follow-up in a GIST Patient
    (Springer, 2021) Yararbas, U.; Tamer, F.
    [No Abstract Available]
  • Küçük Resim Yok
    Öğe
    The real-world outcomes of Lutetium-177 PSMA-617 radioligand therapy in metastatic castration-resistant prostate cancer: Turkish Oncology Group multicenter study
    (John Wiley and Sons Inc, 2023) Almuradova, E.; Seyyar, M.; Arak, H.; Tamer, F.; Kefeli, U.; Koca, S.; Sen, E.
    Metastatic castration-resistant prostate cancer (mCRPC) remains a challenging condition to treat despite recent advancements. This retrospective study aimed to assess the activity and tolerability of Lutetium-177 (Lu-177) PSMA-617 radioligand therapy (RLT) in mCRPC patients across multiple cancer centers in Turkey. The study included 165 patients who received at least one cycle of Lu-177 PSMA-617 RLT, with the majority having bone metastases and undergone prior treatments. Prostate-specific antigen (PSA) levels were assessed before each treatment cycle, and the biochemical response was evaluated in accordance with the Prostate Cancer Work Group 3 Criteria. The PSA decline of ?50% was classified as a response, while an increase of ?25% in PSA levels was indicative of progressive disease. Neither response nor progression was considered as stable disease. The Lu-177 PSMA-617 RLT led to a significant PSA response, with 50.6% of patients achieving a >50% decrease in PSA levels. Median overall survival (OS) and progression-free survival were 13.5 and 8.2 months, respectively. Patients receiving Lu-177 PSMA-617 RLT in combination with androgen receptor pathway inhibitors (ARPIs) had a higher OS compared to those receiving Lu-177 PSMA-617 RLT alone (18.2 vs 12.3 months, P =.265). The treatment was generally well-tolerated, with manageable side effects such as anemia and thrombocytopenia. This study provides real-world evidence supporting the effectiveness and safety of Lu-177 PSMA-617 RLT in mCRPC patients, particularly when used in combination with ARPIs. These findings contribute to the growing body of evidence on the potential benefits of PSMA-targeted therapies in advanced prostate cancer. © 2023 UICC.

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