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  • Küçük Resim Yok
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    Central Nervous System Fungal Infections in Children with Leukemia, Risk Factors and Outcome: A Multicentric Study
    (Amer Soc Hematology, 2018) Kebudi, Rejin; Karaman, Serap; Kizilocak, Hande; Karakas, Zeynep; Evim, Melike Sezgin; Demirag, Bengu; Kaya, Zuhre; Yarali, Husniye Nese; Caliskan, Umran; Karagun, B. Sahin; Albayrak, Canan; Yilmaz, Sebnem; Karapinar, Deniz; Unal, Ekrem; Gunes, Adalet Meral; Tahta, Neryal; Guzelkucuk, Zeliha; Kocak, Ulker; Celkan, Tiraje
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    Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment
    (Galenos Yayincilik, 2020) Acar, Sezer; Gozmen, Salih; Bayraktaroglu, Selen; Acar, Sultan O.; Tahta, Neryal; Aydinok, Yesim; Vergin, Raziye C.
    Objective: There are a limited number of studies evaluating iron overload in childhood leukemia by magnetic resonance imaging (MRI). The aim of this study was to determine liver iron content (LIC) by MRI in children with acute lymphoblastic leukemia (ALL) who had completed treatment and to compare those values with serum iron parameters. Materials and Methods: A total of 30 patients between the ages of 7 and 18 who had completed ALL treatment were included in the study. Serum iron parameters (serum iron, serum ferritin [SF], and total iron-binding capacity) and liver function tests were studied. R2 MRI was performed for determining LIC. Results: Normal LIC was detected in 22 (63.4 %) of the cases. Seven (23.3 %) had mild and 1 (3.3%) had moderate liver iron deposition. in contrast, severe iron overload was not detected in any of the cases. LIC levels were correlated with the numbers of packed red blood cell (pRBC) transfusions (r=0.637, p<0.001), pRBC transfusion volume (r=0.449, p<0.013), SF levels (r=0.561, p=0.001), and transferrin saturation (r=0.353, p=0.044). in addition, a positive correlation was found between the number of pRBC transfusions and SF levels (r=0.595, p<0.001). Conclusion: We showed that the frequency of liver iron deposition was low and clinically less significant after the end of treatment in childhood ALL patients. UC was demonstrated to be related to SF and transfusion history. These findings support that SF and transfusion history may be used as references for monitoring iron accumulation or identifying cases for further examinations such as MRI.
  • Küçük Resim Yok
    Öğe
    Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of Treatment
    (2020) Bayraktaroğlu, Selen; Acar, Sezer; Tahta, Neryal; Aydınok, Yeşim; Gözmen, Salih; Acar, Sultan O.; Vergin, Raziye C.
    Objective: There are a limited number of studies evaluating ironoverload in childhood leukemia by magnetic resonance imaging(MRI). The aim of this study was to determine liver iron content (LIC)by MRI in children with acute lymphoblastic leukemia (ALL) who hadcompleted treatment and to compare those values with serum ironparameters.Materials and Methods: A total of 30 patients between the ages of 7and 18 who had completed ALL treatment were included in the study.Serum iron parameters (serum iron, serum ferritin [SF], and total ironbinding capacity) and liver function tests were studied. R2 MRI wasperformed for determining LIC.Results: Normal LIC was detected in 22 (63.4%) of the cases. Seven(23.3%) had mild and 1 (3.3%) had moderate liver iron deposition. Incontrast, severe iron overload was not detected in any of the cases.LIC levels were correlated with the numbers of packed red blood cell(pRBC) transfusions (r=0.637, p<0.001), pRBC transfusion volume(r=0.449, p<0.013), SF levels (r=0.561, p=0.001), and transferrinsaturation (r=0.353, p=0.044). In addition, a positive correlationwas found between the number of pRBC transfusions and SF levels(r=0.595, p<0.001).Conclusion: We showed that the frequency of liver iron depositionwas low and clinically less significant after the end of treatment inchildhood ALL patients. LIC was demonstrated to be related to SF andtransfusion history. These findings support that SF and transfusionhistory may be used as references for monitoring iron accumulationor identifying cases for further examinations such as MRI.