Yazar "Tabel Y." seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association between RAS gene polymorphisms (ACE I/D, AGT M235T) and Henoch-Schönlein purpura in a Turkish population(Hindawi Limited, 2013) Nalbantoglu S.; Tabel Y.; Mir S.; Serdaroglu E.; Berdeli A.Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis of autoimmune hypersensitivity, and renin-angiotensin system (RAS) regulates vascular homeostasis and inflammation with activation of cytokine release. Thus, we aimed to investigate the association between HSP and ACE I/D and AGT M235T polymorphisms. Genotyping was determined by allele specific PCR and PCR-RFLP. We obtained a significant difference in genotype distribution (p=0.003) and allele frequencies (p<0.001) of ACE I/D polymorphism between patients and controls, while no significant association was detected in genotype distribution (p> 0.05) and allele frequencies (p> 0.05) of the AGT M235T polymorphism. Risk assessment showed significant risk for HSP in the subjects both with the ID + DD genotype (p=0.019, OR: 2.288, 95% CI: 1.136-4.609) and D allele (OR: D vs. I: 2.0528, 95% CI: 1.3632-3.0912, p=0.001) while no significant risk was obtained for HSP in the subjects both with the MT + TT genotype (p=0.312, OR: 1.3905, 95% T vs. M: 1.065, 95% CI: 0.7326-2.6391) and T allele (OR: patients were stratified by the presence of certain systemic complications of HSP, no significant association was detected with ACE I/D, and AGT M235T polymorphisms. Our findings suggest that ACE I/D polymorphism is significantly associated with HSP susceptibility. © 2013 IOS Press and the authors. All rights reserved.Öğe Association of macrophage migration inhibitory factor -173C allele polymorphism with steroid resistance in children with nephrotic syndrome(2005) Berdeli A.; Mir S.; Ozkayin N.; Serdaroglu E.; Tabel Y.; Cura A.The potential effects of macrophage migration inhibitory factor (MIF) on the natural immune response are due to the inhibition of immune cell activation, which is regulated by glucocorticoids. In this study, we investigated MIF -173G/C genotype and C allele frequency in 214 patients with idiopathic nephrotic syndrome (INS) and 103 healthy volunteers. We found significant increases in GC genotype (OR=3, p=0.0009) and C allele frequency (OR=2.5, p=0.0007) in INS. Upon classifying patients as steroid responsive (n =137) or resistant (n =77), a 20-fold over-expression of the CC-genotype was found in the steroid-resistant group (OR=20, p=0.0002). Moreover, a significant increase in C allele frequency in patients with focal segmental glomerulosclerosis (FSGS) has also been noted when compared with other histopathological groups (OR=3.2, p=0.0017). Furthermore, significant increases in the CC genotype (15.6% vs 3.3%) and C allele (75% vs 32%) frequencies have been found in patients with permanent renal function failure (p =0.013 and p =0.0002, respectively). Patients with the CC genotype were found to be at considerably increased risk of permanent renal failure (OR=5.43, p=0.013) and end-stage renal disease (OR=5.53, p=0.020). Additionally, there was a correlation between age of detection of proteinuria and CC genotype. We found an earlier age of onset of proteinuria in patients with the CC genotype (1.9±1.7 years) than in patients who were GC-heterozygous (3.7±3.1 years) and GG-homozygous (3.6±2.9 years, p=0.88). In summary, our results indicate that the MIF-173 C allele confers an increased risk of susceptibility to INS and plays a crucial role in glucocorticoid responsiveness. © IPNA 2005.Öğe Development of a medication adherence scale for familial Mediterranean fever (MASIF) in a cohort of Turkish children(Clinical and Experimental Rheumatology S.A.S., 2015) Yesilkaya S.; Acikel C.; Fidanci B.E.; Polat A.; Sozeri B.; Ayaz N.A.; Makay B.B.; Simsek D.; Akinci N.; özçelik G.; Kavukçu S.; Emre S.; Donmez O.; Delibas A.; Yüksel S.; Berdeli A.; Poyrazoglu H.; Saldir M.; Fidanci K.; çakar N.; Peru H.; Bakkaloglu S.; Tabel Y.; Sari O.; Aydogan U.; Ozenc S.; Basbozkurt G.; Unsal E.; Kasapcopur O.; Gok F.; Ozen S.; Demirkaya E.Objective. To develop and assess the validity and reliability of an adherence scale concerning medical treatment in paediatric FMF patients. Methods. The Medication Adherence Scale in FMF Patients (MASIF) is a 18-item questionnaire that evaluates adherence to medication in four domains. Validation of the instrument was accomplished in paediatric FMF patients (aged 2-18 years) under medication at least for 6 months. The first step was to build up the scale through qualitative approach (with interviews using semi-structured questions). Validation analyses included assessment of feasibility, face and content validity; construct validity, internal consistency and test-retest reliability. Results. One hundred and fifty patients with FMF were enrolled in the study. The mean age of the patients was 11.11±4.02 years and 48.7% of them were male. The MASIF was found to be feasible and valid for both face and content. It correlated with the Morisky Medication Adherence Scale as a gold standard thereby demonstrating good construct validity (r=0.515, p < 0.001). Assessment of content validity identified four subscales. The internal consistency, Cronbach's alpha was 0.728. There was a positive and significant correlation between test and retest scores (r=0.843; p < 0.001). Also, a significant correlation between parents' and children's reports (r=0.781, p < 0.001). Conclusion. Based on these results, the use of this scale to assess and follow up the adherence to treatment in paediatric FMF patients under medical treatment is recommended. © Clinical and Experimental Rheumatology 2015.Öğe Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch-Schönlein purpura(2012) Tabel Y.; Mir S.; Berdeli A.The objective of this study is to investigate the association between IL-8 gene 2767 G/A polymorphism and clinical features, kidney involvement and prognosis in childhood Henoch Schnölein purpura (HSP). A total of 115 patients with HSP (59 male, 56 female) were included in the study with age at diagnosis between 2 and 17 years (8.0 ± 3.0). Hundred and eight healthy adults were included in the study as controls. The patients had been followed up for kidney involvement for at least 6 months and in average 8.2 ± 7.5 months. Interleukin 8 (IL-8) gene 2767 G/A polymorphism was studied by PCR-RFLP method. Frequency of the "A" allele was 0.37 in the patient group, whereas it was 0.36 in the control group. The difference was not statistically significant (P = 0.696). No association was detected between the IL-8 gene G/A polymorphism and the clinical, laboratory, and demographic data related to the patients with HSP. Kidney involvement was more common in those with the G/A polymorphism of the IL-8 gene. While a 0.44 frequency of the "A" allele was detected in those with kidney involvement, this rate was 0.29 in those with no kidney involvement (P = 0.046). Follow-up of those with the "A" allele revealed higher proteinuria (P = 0.023, odds ratio 0.176, 95% CI 0.034-0.917) and higher creatinine levels (P = 0.049, odds ratio 0.024, 95% CI 0.036-0.094). These results suggest that the kidney involvement is more common in patients with the "A" allele, and degree of proteinuria and creatinine levels is higher in these patients at follow-up. © Springer-Verlag 2011.Öğe Lack of association between macrophage migration inhibitory factor gene promoter (-173 G/C) polymorphism and childhood Henoch-Schönlein purpura in Turkish patients(2013) Nalbantoglu S.; Tabel Y.; Mir S.; Berdeli A.Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis of autoimmune hypersensitivity with rash, arthritis, abdominal pain and renal involvements. Macrophage migration inhibitory factor (MIF) is a immunoregulatory proinflammatory cytokine, and a major mediator at the inflammatory sites. The pathogenesis of HSP has not been fully elucidated. Here we aimed to assess the influence of macrophage migration inhibitory factor gene (-173 G/C) polymorphism in the susceptibility and clinical expression of patients with Henoch-Schönlein purpura (HSP). HSP patients (n:139) and ethnically matched healthy controls (n:100) were genotyped by PCR-RFLP. Genotype analysis of both polymorphisms did not reveal a significant deviation from Hardy-Weinberg equilibrium in any group (p>0.05). No significant difference was obtained in genotype distribution (p>0.05) and allele frequencies (p>0.05) between patients and controls. A statistically significant genotype-phenotype correlation was not obtained when HSP patients were stratified by the presence of certain systemic complications and the macrophage migration inhibitory factor gene (-173 G/C) polymorphism (p>0.05). A significant risk was not observed in the subjects both with the GC + CC genotype (p=0.06, OR: 0.5538, 95% CI: 0.2985-1.0274) and C allele (odds ratio: C vs. G: 1.799, 95% CI: 1.002-3.23, p=0.05). Our findings suggest that MIF gene -173 G/C polymorphism is not associated with HSP in the present Turkish population. © 2013 Elsevier Ltd.Öğe Lack of association between TNF? gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients(2006) Berdeli A.; Tabel Y.; Celik H.A.; Ozyürek R.; Dogrusoz B.; Aydin H.H.Objective: Acute rheumatic fever (ARF) is a multisystem inflammatory disease process that follows nasopharyngeal infection caused by group A streptococcus (GAS) (Streptococcus pyogenes). Recent studies have demonstrated that allelic variations at the tumour necrosis factor alpha (TNF?) locus are involved in the nature of rheumatic diseases such as juvenile idiopathic arthritis and rheumatic heart disease. Thus, TNF? polymorphisms at -308 in ARF patients might be useful in contributing to identification of the primary factors associated with pathogenesis of ARF. Methods: We performed a case-control association study between the common G/A promoter polymorphism at position -308 in the TNF? gene and ARF in Turkish patients, investigating whether this locus acts as a risk factor or has a modifying effect. Results and Conclusion: Previous studies have reported that TNF? plays a major role in the pathogenesis of a number of autoimmune and inflammatory diseases. Moreover, significantly elevated TNF? levels were reported in patients with ARF. However, in our sample of patients with ARF (n=66), no such association was found. No interactive effect was found between the TNF? polymorphism at position -308 and no association was detected with disease progression. These findings suggest that the role of TNF? in ARF may be in linkage disequilibrium with some other severity genes not yet genetically determined. © 2006 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation.Öğe The long-term outcomes of idiopathic hypercalciuria in children(2006) Tabel Y.; Mir S.Objective: Idiopathic hypercalciuria (IH) is a metabolic risk factor in patients with urinary calcium stones and implicated in 30%-50% of all urinary stone diseases. Clinical manifestations and distribution of types of IH are reviewed, as well as current treatment methods and long-term outcomes. Patients: A total of 131 patients (70 boys and 61 girls), aged 1-15 years (mean 7.9 ± 3.19 years), were studied. Follow up was between 6 months and 16 years (mean 4.1 ± 6.8 years). Results: Fifty-three patients (40%) were diagnosed following calcium challenge as renal type, and 51 (39%) as absorptive type of hypercalciuria. Whereas 72 patients (54.9%) had a family history of nephrolithiasis, 59 patients did not. Nephrolithiasis was found in 27 patients (20%) on admission (absorptive = 9.9%, renal = 4.5%, undetermined = 6.1%), but developed in eight other patients (6.1%) (absorptive = 2.2%, renal = 0.7%, undetermined = 3.8%). Urinary calcium excretion reversed in 65 patients with the suggested diet therapy; it recurred in 30 patients (22.9%) (absorptive = 9.1%, renal = 11.4%, undetermined = 2.2%) but 35 returned to normal definitively (26.7%) (absorptive = 11.4%, renal = 12.9%, undetermined = 2.2%). No change was seen in the status of 50 patients (38.1%) (absorptive = 18.3%, renal = 16%, undetermined = 3.8%). Conclusion: IH may be accompanied by nephrolithiasis; type must be determined and those patients with absorptive type should be followed for nephrolithiasis. Our results suggest that formation of new stones could be prevented with diet and thiazide therapies in IH. © 2005 Journal of Pediatric Urology Company.
