Yazar "Sussmuth, Roderich D." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Combined venom profiling and cytotoxicity screening of the Radde's mountain viper (Montivipera raddei) and Mount Bulgar Viper (Montivipera bulgardaghica) with potent cytotoxicity against human A549 lung carcinoma cells
    (Pergamon-Elsevier Science Ltd, 2017) Nalbantsoy, Ayse; Hempel, Benjamin-Florian; Petras, Daniel; Heiss, Paul; Gocmen, Bayram; Igci, Nasit; Yildiz, Mehmet Zulfu; Sussmuth, Roderich D.
    Here we report the first characterization of the endemic Mount Bulgar Viper (Montivipera bulgardaghica) and Radde's mountain viper (Montivipera raddei) venom by a combined approach using intact mass profiling and bottom-up proteomics. The cytotoxicity screening of crude venom as well as isolated serine proteases revealed a high activity against A549 human lung carcinoma cells. By means of intact mass profiling of native and reduced venom we observed basic and acidic phospholipases type A(2). Moreover, the analysis revealed snake venom metalloproteases, cysteine-rich secretory proteins, disintegrins, snake venom serine proteases, C-type lectins, a vascular endothelial growth factor and an L-amino acid oxidase. (C) 2017 Elsevier Ltd. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Deuterium-Labeled Precursor Feeding Reveals a New pABA-Containing Meroterpenoid from the Mango Pathogen Xanthomonas citri pv. mangiferaeindicae
    (Amer Chemical Soc, 2016) Saleh, Hesham; Petras, Daniel; Mainz, Andi; Kerwat, Dennis; Nalbantsoy, Ayse; Erzurumlu, Yalcin; Sussmuth, Roderich D.
    A new para-aminobenzoic-acid-containing natural product from the mango pathogenic organism Xanthomonas citri pv. mangiferaeindicae is described. By means of stable isotope precursor feeding combined with nontargeted LC-MS/MS, the generated spectra were clustered and visualized in a molecular network. This led to the identification of a new member of the meroterpenoids, termed xanthomonic acid, which is composed of an isoprenylated Para-amino benzoic acid. In vitro cytotoxicity assays demonstrated activity of xanthomonic acid against several human cancer cell lines by induction of autophagy.