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    Evaluation of platelet-rich plasma efficacy in melasma
    (Taylor & Francis Inc, 2022) Acar, Ayda; Ozturk, Ayris; Sokmen, Nur; Unal, Idil; Sagduyu, Ilgen Ertam
    Platelet-rich plasma (PRP), which is widely used in many dermatologic conditions, has also been used in the treatment of melasma in recent years. The objective of this study is to determine the efficacy of PRP in melasma. Fifteen female patients with melasma participated in this study. Intradermal PRP was performed every 3 weeks for three times. We photographed all participants, performed Melasma Area and Severity Index (MASI), and measured melanin and erythema index (EI) with mexameter before every session and 1 month after the last session. Patients self-assessment of pigmentation grade (0-10) were also employed at baseline and 1 month after the last procedure. Mean MASI of the patients reduced from 10 +/- 3.6 to 7.3 +/- 2.5. Melanin index (MI) and EI evaluated by mexameter reduced from 256.5 +/- 31 to 238.9 +/- 29.9 and from 329.9 +/- 53.8 to 322.7 +/- 77.6, respectively. Mean patients self-assessment score (PSS) reduced from 8.3 +/- 1.3 to 5 +/- 1.4. Mean MASI, MI, and PSS reduction after treatment was found significant (p = .001, p = .000, p = .000). Intradermal application of PRP is an effective option for treatment of melasma. It also has other benefits like improvement in skin appearance. Because recurrence is common in melasma, depigmenting agents should be used after all procedures.
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    Extranasal extranodal NK/T cell lymphoma: A post-transplantation lymphoproliferative disease
    (Wiley, 2019) Acar, Ayda; Nurlu, Ertan; Sokmen, Nur; Ozsan, Nazan; Davulcu, Eren A.; Ceylan, Can
    Extranodal NK/T cell lymphoma (ENKTL) is a rare form of non-Hodgkin lymphoma. It mostly occurs in the upper respiratory tract. Cutaneous involvement can be seen among the extranasal ENKTLs. After solid organ and haematopoietic stem cell transplantation, post-transplantation lymphoproliferative disease because of immunosuppressive therapy is usually B cell-derived; T and NK/T cell-derived disease is rarely seen. A 43-year-old female patient who had renal transplantation 14 years ago presented with cutaneous ulceration and subcutaneous nodules located in the abdomen. The patient was diagnosed with ENKTL, nasal type. Although it is rare, ENKTL nasal type is a lymphoproliferative disease that should be considered in the differential diagnosis of ulcerated cutaneous tumoural lesions.