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    Difficulties experienced by caregivers of patients diagnosed with osteogenesisimperfecta (OI): Example of a hospital
    (Pakistan Medical Association, 2015) Arabaci L.B.; Bozkurt S.; Vara S.; Ozen S.; Darcan S.; Simsek D.G.
    Objective: To identify the difficulties experienced by medical caregivers of inpatients diagnosed with osteogenesisimperfecta. Methods: The descriptive, cross-sectional study was conducted at a university hospital in western Turkey from April to May, 2012, and comprised relatives providing care to patients who were diagnosed with osteogenesisimperfecta and were being treated in the paediatric endocrinology unit. Data was collected via face-to-face interviews with patient relatives. The 35-itemquestionnaire had 16 open-ended and 19 close-ended questions. Results: The mean age of the 46 caregivers was 35.52±6.65 years, and 43(93.5%) of them were mothers. All of them said they felt anxious (100%), while 44(95.7%) felt sad/sorrow, 41(89.1%) puzzled, 40(87.0%) nervous, 40(87.0%) frightened, 39(84.8%) disappointed, 29(63%) shocked, and 28(60.9%) depressed when they first heard the diagnosis. Overall, 26(56.5%) experienced physical, 45(97.8%) psychological, 45(97.8%) social, and 35(76.1%) economic changes and difficulties, while 24(52.1%) had no social support. Of all the patient relatives, 38(82.6%) were unable to obtain adequate information about the disorder from the healthcare team. Conclusion: Caregivers of patients diagnosed with osteogenesisimperfecta experienced psychological and social difficulties.. © 2015, Pakistan Medical Association. All rights reserved.
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    Effects of pesticides used in agriculture on the development of precocious puberty
    (2012) Ozen S.; Darcan S.; Bayindir P.; Karasulu E.; Simsek D.G.; Gurler T.
    The present study aims to evaluate the effects of pesticides on premature breast development. Forty-five girls (group 1) with premature breast development living in the Menderes region, where greenhouse cultivation is the main income, 16 girls (group 2) living in Izmir city with early puberty, and 33 girls (group 3) who had no signs of puberty were included in the study. Endosulphan 1, endosulphan 2, endosulphan sulphate, methoxychlor, vinclozolin, 4,4-dichlorodiphenyldichlorethylene (DDE), 4,-dichloro-diphenyltrichloroethane (DDT), and 2,4-DDT were evaluated in the serum and adipose tissues of the groups by using a gas chromatography-mass spec-trometry method. With the exception of 4,4'-DDE, the pesticides studied were undetectable in the serum and adipose tissue samples. The levels of basal luteinizing hormone (LH), stimulated LH, follicle-stimulating hormone, and the long axis of the uterus and both ovaries were significantly different in the girls who had premature thelarche and detectable 4,4'-DDE levels compared to the girls who had premature thelarche and undetectable 4,4'-DDE levels in serum and adipose tissues. The presence and levels of pesticides in serum and adipose tissues were not related to precocious puberty (PP). The mechanisms that lead to PP may also result in obesity, and obesity may be the underlying cause for PP in this group. © Springer Science+Business Media B.V. 2011.
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    Primary hyperparathyroidism in a young adult presenting with severe hypertension
    (Walter de Gruyter GmbH, 2010) Ozen S.; Celik A.; Alper H.; Simsek D.G.; Darcan S.
    Hypertension is a significant cause of morbidity and mortality in childhood. Endocrinerelated hypertension is rare in children. Hypercalcmia due to hyperparathyroidism is a rare cause of endocrine-related hypertension in childhood. We present a patient with severe headache, who was diagnosed with hypertension due to hyperparathyroidism. Hyperparathyroidism should be kept in mind in children with hypertension accompanied by hypercalcemia and hypophosphatemia. © Freund Publishing House Ltd.,.