Yazar "Simsek, D. Goksen" seçeneğine göre listele

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    CLINICAL OVERVIEW OF INSULIN RESISTANCE IN PATIENTS WITH TYPE 1 GAUCHER DISEASE
    (Elsevier, 2008) Ucar, S. Kalkan; Coker, M.; Argin, M.; Kara, S.; Simsek, D. Goksen; Darcan, S.
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    Individualization of enzyme replacement therapy and of therapy for severe skeletal manifestations in a child with Gaucher disease
    (Elsevier, 2007) Ucar, S. Kalkan; Coker, M.; Argun, M.; Kara, S.; Erhan, E.; Simsek, D. Goksen; Darcan, S.
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    A monocentric pilot study of an antioxidative defense and hsCRP in pediatric patients with glycogen storage disease type IA and III
    (Elsevier Sci Ltd, 2009) Ucar, S. Kalkan; Coker, M.; Sozmen, E.; Simsek, D. Goksen; Darcan, S.
    Background and aims: Patients with glycogen storage disease type Ia (GSD Ia) and III (GSD III) do not develop premature atherosclerosis despite hyperlipidemia. The aim of the study was to investigate the oxidative-antioxidative conditions and high sensitivity C-reactive protein (hsCRP) levels in patients with glycogen storage disease type Ia and III. Methods: We measured lipid profile and lipid peroxidation products in comparison with hsCRP and antioxidative status: trolox equivalent antioxidant capacity, total antioxidant activity, proteinaceous antioxidant enzymes (catalase, superoxide dismutase, paraoxonase, arylesterase), aqueous antioxidants (vitamin C, uric acid, bilirubin, total protein) and lipid-soluble antioxidants (alpha-tocopherol, beta-carotene). The study included 50 individuals: 22 with GSD Ia, 9 with GSD III, and 19 healthy subjects. Results: GSD Ia patients showed a marked hypertriglyceridemia, whereas GSD III patients demonstrated hypercholesterolemia with elevated LDL-cholesterol and decreased HDL-chotesterol levels. Lipid peroxidation levels increased in both GSD groups. The antioxidant activity elevated in GSD la group. No significant differences were found in the activities of antioxidant enzymes. Uric acid and alpha-tocopherol levels increased, however, vitamin C and beta-carotene reduced in both GSD groups. The hsCRP levels did not differ among the groups. Conclusions: In summary our study revealed normal levels of hsCRP in spite of the dyslipidemic status in both GSD patients. The increased plasma antioxidative defense in GSD la might be attributed not only to the elevated uric acid but also to the supplemented vitamin E Levels. These findings should motivate further investigations in the area of atherosclerotic escape of GSDs. (c) 2008 Elsevier B.V. All rights reserved.